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A Model for UV-Induction of Skin Cancer.

Ouhtit A, Ananthaswamy HN - J. Biomed. Biotechnol. (2001)

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development of UV-induced skin cancer is a complex process UV on target cells (keratinocytes) for neoplastic transformation, and the other involves the effects of UV on the host's immune system... There is evidence to indicate that UV-induced DNA damage plays an UV-induced DNA damage causes an elevation of p53 recently demonstrated that p53 may up-regulate bax and down-regulate Bcl-2 protein resulting in apoptosis and mutations are relatively more resistant to UV-induced apoptosis, the development of basal cell carcinoma (BCC)... The human ptc gene was found to colocalize with the map Sporadic ptc mutations have been found in BCC from otherwise normal individuals, some of not been reported in SCC... Nonetheless, these results suggest that cancer, by inducing genetic alterations in keratinocytes leading

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Pathways involved in skin cancer development.
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Figure 1: Pathways involved in skin cancer development.

Mentions: The cellular and molecular events that contribute to thedevelopment of UV-induced skin cancer is a complex processinvolving at least two distinct pathways that interact or convergeto cause skin cancer (Figure 1). One pathway involves the action of UV on target cells (keratinocytes) for neoplastic transformation, and the otherinvolves the effects of UV on the host's immune system [1].There is evidence to indicate that UV-induced DNA damage plays animportant role in both pathways.


A Model for UV-Induction of Skin Cancer.

Ouhtit A, Ananthaswamy HN - J. Biomed. Biotechnol. (2001)

Pathways involved in skin cancer development.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC79671&req=5

Figure 1: Pathways involved in skin cancer development.
Mentions: The cellular and molecular events that contribute to thedevelopment of UV-induced skin cancer is a complex processinvolving at least two distinct pathways that interact or convergeto cause skin cancer (Figure 1). One pathway involves the action of UV on target cells (keratinocytes) for neoplastic transformation, and the otherinvolves the effects of UV on the host's immune system [1].There is evidence to indicate that UV-induced DNA damage plays animportant role in both pathways.

View Article: PubMed Central - HTML - PubMed

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

development of UV-induced skin cancer is a complex process UV on target cells (keratinocytes) for neoplastic transformation, and the other involves the effects of UV on the host's immune system... There is evidence to indicate that UV-induced DNA damage plays an UV-induced DNA damage causes an elevation of p53 recently demonstrated that p53 may up-regulate bax and down-regulate Bcl-2 protein resulting in apoptosis and mutations are relatively more resistant to UV-induced apoptosis, the development of basal cell carcinoma (BCC)... The human ptc gene was found to colocalize with the map Sporadic ptc mutations have been found in BCC from otherwise normal individuals, some of not been reported in SCC... Nonetheless, these results suggest that cancer, by inducing genetic alterations in keratinocytes leading

No MeSH data available.


Related in: MedlinePlus