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Growth factors in lung development and disease: friends or foe?

Desai TJ, Cardoso WV - Respir. Res. (2001)

Bottom Line: Growth factors mediate tissue interactions and regulate a variety of cellular functions that are critical for normal lung development and homeostasis.Besides their involvement in lung pattern formation, growth and cell differentiation during organogenesis, these factors have been also implicated in modulating injury-repair responses of the adult lung.Altered expression of growth factors, such as transforming growth factor beta1, vascular endothelial growth factor and epidermal growth factor, and/or their receptors, has been found in a number of pathological lung conditions.

View Article: PubMed Central - HTML - PubMed

Affiliation: Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts, USA.

ABSTRACT
Growth factors mediate tissue interactions and regulate a variety of cellular functions that are critical for normal lung development and homeostasis. Besides their involvement in lung pattern formation, growth and cell differentiation during organogenesis, these factors have been also implicated in modulating injury-repair responses of the adult lung. Altered expression of growth factors, such as transforming growth factor beta1, vascular endothelial growth factor and epidermal growth factor, and/or their receptors, has been found in a number of pathological lung conditions. In this paper, we discuss the dual role of these molecules in mediating beneficial feedback responses or responses that can further damage lung integrity; we shall also discuss the basis for their prospective use as therapeutic agents.

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Growth factors in development and disease. Major roles of selected growth factors in embryonic and postnatal lung development (left) and their potential association with lung pathological conditions (right) are shown. BMP, bone morphogenetic protein; EGF, epidermal growth factor; FGF, fibroblast growth factor; GM-CSF, granulocyte macrophage-colony stimulating factor; PDGF, platelet-derived growth factor; TGF, transforming growth factor; VEGF, vascular endothelial growth factor.
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Figure 1: Growth factors in development and disease. Major roles of selected growth factors in embryonic and postnatal lung development (left) and their potential association with lung pathological conditions (right) are shown. BMP, bone morphogenetic protein; EGF, epidermal growth factor; FGF, fibroblast growth factor; GM-CSF, granulocyte macrophage-colony stimulating factor; PDGF, platelet-derived growth factor; TGF, transforming growth factor; VEGF, vascular endothelial growth factor.

Mentions: In the fully developed lung, these signals are presumably balanced to maintain cellular activities at equilibrium, so that normal lung structure and function are preserved. The existence of such a balance has been inferred from the abnormal expression of these factors or their inappropriate signaling activation in pathological lung conditions. Growth factor imbalance thus describes a situation in which the expression or activity of a factor predominates over another, usually of opposing effect, within the same system. While growth factors are key regulators of alveolar formation, they have also been implicated in abnormal lung remodeling that results in fibrosis and changes in the architecture of the airspaces (see Fig. 1). An analysis of their role in development and disease follows.


Growth factors in lung development and disease: friends or foe?

Desai TJ, Cardoso WV - Respir. Res. (2001)

Growth factors in development and disease. Major roles of selected growth factors in embryonic and postnatal lung development (left) and their potential association with lung pathological conditions (right) are shown. BMP, bone morphogenetic protein; EGF, epidermal growth factor; FGF, fibroblast growth factor; GM-CSF, granulocyte macrophage-colony stimulating factor; PDGF, platelet-derived growth factor; TGF, transforming growth factor; VEGF, vascular endothelial growth factor.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC64813&req=5

Figure 1: Growth factors in development and disease. Major roles of selected growth factors in embryonic and postnatal lung development (left) and their potential association with lung pathological conditions (right) are shown. BMP, bone morphogenetic protein; EGF, epidermal growth factor; FGF, fibroblast growth factor; GM-CSF, granulocyte macrophage-colony stimulating factor; PDGF, platelet-derived growth factor; TGF, transforming growth factor; VEGF, vascular endothelial growth factor.
Mentions: In the fully developed lung, these signals are presumably balanced to maintain cellular activities at equilibrium, so that normal lung structure and function are preserved. The existence of such a balance has been inferred from the abnormal expression of these factors or their inappropriate signaling activation in pathological lung conditions. Growth factor imbalance thus describes a situation in which the expression or activity of a factor predominates over another, usually of opposing effect, within the same system. While growth factors are key regulators of alveolar formation, they have also been implicated in abnormal lung remodeling that results in fibrosis and changes in the architecture of the airspaces (see Fig. 1). An analysis of their role in development and disease follows.

Bottom Line: Growth factors mediate tissue interactions and regulate a variety of cellular functions that are critical for normal lung development and homeostasis.Besides their involvement in lung pattern formation, growth and cell differentiation during organogenesis, these factors have been also implicated in modulating injury-repair responses of the adult lung.Altered expression of growth factors, such as transforming growth factor beta1, vascular endothelial growth factor and epidermal growth factor, and/or their receptors, has been found in a number of pathological lung conditions.

View Article: PubMed Central - HTML - PubMed

Affiliation: Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts, USA.

ABSTRACT
Growth factors mediate tissue interactions and regulate a variety of cellular functions that are critical for normal lung development and homeostasis. Besides their involvement in lung pattern formation, growth and cell differentiation during organogenesis, these factors have been also implicated in modulating injury-repair responses of the adult lung. Altered expression of growth factors, such as transforming growth factor beta1, vascular endothelial growth factor and epidermal growth factor, and/or their receptors, has been found in a number of pathological lung conditions. In this paper, we discuss the dual role of these molecules in mediating beneficial feedback responses or responses that can further damage lung integrity; we shall also discuss the basis for their prospective use as therapeutic agents.

Show MeSH
Related in: MedlinePlus