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Therapeutic outcome of nasopharyngeal carcinoma with cranial nerve palsy: a single institution experience of 104 patients

View Article: PubMed Central - PubMed

ABSTRACT

Purpose: Cranial nerve (CN) palsy is the main symptom in patients with locally advanced nasopharyngeal carcinoma (NPC). This study aimed to evaluate the therapeutic outcome of NPC with CN palsy and to analyze the prognostic factors.

Patients and methods: A total of 104 NPC patients with CN palsy curatively treated by conventional (n=44) or conformal (n=60) radiotherapy (RT) were enrolled. Upper CN palsy was present in 81 patients, lower CN palsy in four patients, and both upper and lower CN palsy in 19 patients. Forty-one patients had CN palsy for >2 months before diagnosis.

Results: Complete recovery of CN palsy was observed in 74 patients. The actuarial 5-year locoregional control (LRC), distant metastasis-free survival (DMFS), and overall survival (OS) rates were 58.2%, 62.2%, and 38.4%, respectively. No significant difference was observed in CN recovery, LRC, DMFS, or OS for patients treated by conventional versus conformal technique. However, significant reduction of grade 3 or greater toxicities was found in those treated by the conformal technique (odds ratio =0.28).

Conclusion: Patients with CN palsy presenting >2 months before diagnosis were hard to recover from palsy. The LRC, OS, and recovery from CN palsy did not significantly change with the treatment evolution. Patients with complete recovery from CN palsy had longer OS.

No MeSH data available.


Related in: MedlinePlus

Lower cumulative incidence rate of toxicity in conformal RT group.Abbreviation: RT, radiotherapy.
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f3-ott-10-2069: Lower cumulative incidence rate of toxicity in conformal RT group.Abbreviation: RT, radiotherapy.

Mentions: The cumulative incidence rate of toxicity in the conventional group was significantly higher than that of patients in the conformal group (Figure 3). In the multivariate analysis of all possible prognosticators, we found that the conformal RT technique could significantly reduce the occurrence of severe toxicities (odds ratio =0.28, 95% CI =0.10–0.78, P=0.014).


Therapeutic outcome of nasopharyngeal carcinoma with cranial nerve palsy: a single institution experience of 104 patients
Lower cumulative incidence rate of toxicity in conformal RT group.Abbreviation: RT, radiotherapy.
© Copyright Policy
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC5391821&req=5

f3-ott-10-2069: Lower cumulative incidence rate of toxicity in conformal RT group.Abbreviation: RT, radiotherapy.
Mentions: The cumulative incidence rate of toxicity in the conventional group was significantly higher than that of patients in the conformal group (Figure 3). In the multivariate analysis of all possible prognosticators, we found that the conformal RT technique could significantly reduce the occurrence of severe toxicities (odds ratio =0.28, 95% CI =0.10–0.78, P=0.014).

View Article: PubMed Central - PubMed

ABSTRACT

Purpose: Cranial nerve (CN) palsy is the main symptom in patients with locally advanced nasopharyngeal carcinoma (NPC). This study aimed to evaluate the therapeutic outcome of NPC with CN palsy and to analyze the prognostic factors.

Patients and methods: A total of 104 NPC patients with CN palsy curatively treated by conventional (n=44) or conformal (n=60) radiotherapy (RT) were enrolled. Upper CN palsy was present in 81 patients, lower CN palsy in four patients, and both upper and lower CN palsy in 19 patients. Forty-one patients had CN palsy for >2 months before diagnosis.

Results: Complete recovery of CN palsy was observed in 74 patients. The actuarial 5-year locoregional control (LRC), distant metastasis-free survival (DMFS), and overall survival (OS) rates were 58.2%, 62.2%, and 38.4%, respectively. No significant difference was observed in CN recovery, LRC, DMFS, or OS for patients treated by conventional versus conformal technique. However, significant reduction of grade 3 or greater toxicities was found in those treated by the conformal technique (odds ratio =0.28).

Conclusion: Patients with CN palsy presenting >2 months before diagnosis were hard to recover from palsy. The LRC, OS, and recovery from CN palsy did not significantly change with the treatment evolution. Patients with complete recovery from CN palsy had longer OS.

No MeSH data available.


Related in: MedlinePlus