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IT-CARES: an interactive tool for case-crossover analyses of electronic medical records for patient safety

View Article: PubMed Central - PubMed

ABSTRACT

Background:: The significant risk of adverse events following medical procedures supports a clinical epidemiological approach based on the analyses of collections of electronic medical records. Data analytical tools might help clinical epidemiologists develop more appropriate case-crossover designs for monitoring patient safety.

Objective:: To develop and assess the methodological quality of an interactive tool for use by clinical epidemiologists to systematically design case-crossover analyses of large electronic medical records databases.

Material and methods:: We developed IT-CARES, an analytical tool implementing case-crossover design, to explore the association between exposures and outcomes. The exposures and outcomes are defined by clinical epidemiologists via lists of codes entered via a user interface screen. We tested IT-CARES on data from the French national inpatient stay database, which documents diagnoses and medical procedures for 170 million inpatient stays between 2007 and 2013. We compared the results of our analysis with reference data from the literature on thromboembolic risk after delivery and bleeding risk after total hip replacement.

Results:: IT-CARES provides a user interface with 3 columns: (i) the outcome criteria in the left-hand column, (ii) the exposure criteria in the right-hand column, and (iii) the estimated risk (odds ratios, presented in both graphical and tabular formats) in the middle column. The estimated odds ratios were consistent with the reference literature data.

Discussion:: IT-CARES may enhance patient safety by facilitating clinical epidemiological studies of adverse events following medical procedures. The tool’s usability must be evaluated and improved in further research.

No MeSH data available.


Related in: MedlinePlus

IT-CARES’s graphical presentation of the risk of serious bleeding in successive 42-day intervals after total hip replacement.
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ocw132-F4: IT-CARES’s graphical presentation of the risk of serious bleeding in successive 42-day intervals after total hip replacement.

Mentions: In a second step, we configured IT-CARES to estimate the bleeding risk after THR. We identified 515 580 first cases of serious intestinal bleeding. As shown in Figure 4, we observed (i) 576 exposures within the first interval of 42 days during the case period and (ii) 109 exposures within the same time interval during the control period. The associated risk of serious bleeding was significantly elevated during this interval, with an OR [95% CI] = 5.3 [4.3–6.5]. Lalmohamed split the first interval into days 1–14 and days 15–42 (Table 2). The HRs [95% CI] for the bleeding risk were, respectively, 6.0 [4.1–8.9] and 4.3 [3.3–5.7]. The risk was also elevated during the second 42-day interval, and both studies showed that the risk of serious bleeding persisted for 12 weeks.Figure 4.


IT-CARES: an interactive tool for case-crossover analyses of electronic medical records for patient safety
IT-CARES’s graphical presentation of the risk of serious bleeding in successive 42-day intervals after total hip replacement.
© Copyright Policy - cc-by-nc
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5391728&req=5

ocw132-F4: IT-CARES’s graphical presentation of the risk of serious bleeding in successive 42-day intervals after total hip replacement.
Mentions: In a second step, we configured IT-CARES to estimate the bleeding risk after THR. We identified 515 580 first cases of serious intestinal bleeding. As shown in Figure 4, we observed (i) 576 exposures within the first interval of 42 days during the case period and (ii) 109 exposures within the same time interval during the control period. The associated risk of serious bleeding was significantly elevated during this interval, with an OR [95% CI] = 5.3 [4.3–6.5]. Lalmohamed split the first interval into days 1–14 and days 15–42 (Table 2). The HRs [95% CI] for the bleeding risk were, respectively, 6.0 [4.1–8.9] and 4.3 [3.3–5.7]. The risk was also elevated during the second 42-day interval, and both studies showed that the risk of serious bleeding persisted for 12 weeks.Figure 4.

View Article: PubMed Central - PubMed

ABSTRACT

Background:: The significant risk of adverse events following medical procedures supports a clinical epidemiological approach based on the analyses of collections of electronic medical records. Data analytical tools might help clinical epidemiologists develop more appropriate case-crossover designs for monitoring patient safety.

Objective:: To develop and assess the methodological quality of an interactive tool for use by clinical epidemiologists to systematically design case-crossover analyses of large electronic medical records databases.

Material and methods:: We developed IT-CARES, an analytical tool implementing case-crossover design, to explore the association between exposures and outcomes. The exposures and outcomes are defined by clinical epidemiologists via lists of codes entered via a user interface screen. We tested IT-CARES on data from the French national inpatient stay database, which documents diagnoses and medical procedures for 170 million inpatient stays between 2007 and 2013. We compared the results of our analysis with reference data from the literature on thromboembolic risk after delivery and bleeding risk after total hip replacement.

Results:: IT-CARES provides a user interface with 3 columns: (i) the outcome criteria in the left-hand column, (ii) the exposure criteria in the right-hand column, and (iii) the estimated risk (odds ratios, presented in both graphical and tabular formats) in the middle column. The estimated odds ratios were consistent with the reference literature data.

Discussion:: IT-CARES may enhance patient safety by facilitating clinical epidemiological studies of adverse events following medical procedures. The tool’s usability must be evaluated and improved in further research.

No MeSH data available.


Related in: MedlinePlus