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Knowledge and attitude regarding pharmacogenetics among formerly pregnant women in the Netherlands and their interest in pharmacogenetic research

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ABSTRACT

Background: Pharmacogenetics is an emerging field currently being implemented to improve safety when prescribing drugs. While many women who take drugs during pregnancy would likely benefit from such personalized drug therapy, data is lacking on the awareness towards pharmacogenetics among women. We aim to determine the level of knowledge and acceptance of formerly pregnant women in the Netherlands regarding pharmacogenetics and its implementation, and their interest in pharmacogenetic research.

Methods: A population-based survey using postal questionnaires was conducted among formerly pregnant women in the Northern parts of the Netherlands. A total of 986 women were invited to participate.

Results: Of the 219 women who returned completed questionnaires (22.2% response rate), only 22.8% had heard of pharmacogenetics, although the majority understood the concept (64.8%). Women who had experience with drug side-effects were more likely to know about pharmacogenetics [OR = 2.06, 95% CI 1.16, 3.65]. Of the respondents, 53.9% were positive towards implementing pharmacogenetics in their future drug therapy, while 46.6% would be willing to participate in pharmacogenetic research. Among those who were either not willing or undecided in this regard, their concerns were about the consequences of the pharmacogenetic test, including the privacy and anonymity of their genetic information.

Conclusion: The knowledge and attitude regarding the concept of pharmacogenetics among our population of interest is good. Also, their interest in pharmacogenetic research provides opportunities for future research related to drug use during pregnancy and fetal outcome.

Electronic supplementary material: The online version of this article (doi:10.1186/s12884-017-1290-z) contains supplementary material, which is available to authorized users.

No MeSH data available.


Population sampling and data collection methods
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Fig1: Population sampling and data collection methods

Mentions: We contacted thirteen community pharmacies that had the highest number of eligible women, according to the IADB.nl database. Eight of these pharmacies agreed to participate in the study. Letters were successfully delivered to 986 selected participants, and 219 (22.2%) returned a completed questionnaire. The sampling method is depicted in Fig. 1 and the general characteristics and medical/medication history of the respondents are shown in Table 1. The mean age of the respondents was 34 years, which is older than that of all eligible women in the database (N = 3689, mean = 29 years, p <0.001). The majority of the respondents had an education level that was middle (46.1%) or high (44.3%). 22 (10%) of the respondents were pregnant at the time they filled in the questionnaire.Fig. 1


Knowledge and attitude regarding pharmacogenetics among formerly pregnant women in the Netherlands and their interest in pharmacogenetic research
Population sampling and data collection methods
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC5391584&req=5

Fig1: Population sampling and data collection methods
Mentions: We contacted thirteen community pharmacies that had the highest number of eligible women, according to the IADB.nl database. Eight of these pharmacies agreed to participate in the study. Letters were successfully delivered to 986 selected participants, and 219 (22.2%) returned a completed questionnaire. The sampling method is depicted in Fig. 1 and the general characteristics and medical/medication history of the respondents are shown in Table 1. The mean age of the respondents was 34 years, which is older than that of all eligible women in the database (N = 3689, mean = 29 years, p <0.001). The majority of the respondents had an education level that was middle (46.1%) or high (44.3%). 22 (10%) of the respondents were pregnant at the time they filled in the questionnaire.Fig. 1

View Article: PubMed Central - PubMed

ABSTRACT

Background: Pharmacogenetics is an emerging field currently being implemented to improve safety when prescribing drugs. While many women who take drugs during pregnancy would likely benefit from such personalized drug therapy, data is lacking on the awareness towards pharmacogenetics among women. We aim to determine the level of knowledge and acceptance of formerly pregnant women in the Netherlands regarding pharmacogenetics and its implementation, and their interest in pharmacogenetic research.

Methods: A population-based survey using postal questionnaires was conducted among formerly pregnant women in the Northern parts of the Netherlands. A total of 986 women were invited to participate.

Results: Of the 219 women who returned completed questionnaires (22.2% response rate), only 22.8% had heard of pharmacogenetics, although the majority understood the concept (64.8%). Women who had experience with drug side-effects were more likely to know about pharmacogenetics [OR&thinsp;=&thinsp;2.06, 95% CI 1.16, 3.65]. Of the respondents, 53.9% were positive towards implementing pharmacogenetics in their future drug therapy, while 46.6% would be willing to participate in pharmacogenetic research. Among those who were either not willing or undecided in this regard, their concerns were about the consequences of the pharmacogenetic test, including the privacy and anonymity of their genetic information.

Conclusion: The knowledge and attitude regarding the concept of pharmacogenetics among our population of interest is good. Also, their interest in pharmacogenetic research provides opportunities for future research related to drug use during pregnancy and fetal outcome.

Electronic supplementary material: The online version of this article (doi:10.1186/s12884-017-1290-z) contains supplementary material, which is available to authorized users.

No MeSH data available.