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Efficacy and safety of Jianzhong decoction in treating peptic ulcers: a meta-analysis of 58 randomised controlled trials with 5192 patients

View Article: PubMed Central - PubMed

ABSTRACT

Background: Jianzhong decoction is widely used to treat peptic ulcers; however, due to lack of systematic evaluations, its clinical efficacy remains controversial. We performed meta-analysis to evaluate the efficacy and safety of Jianzhong decoction in treating peptic ulcers.

Methods: Studies were systematically retrieved from PubMed, Embase, Cochrane library, China National Knowledge Infrastructure, Wanfang Database, Chongqing VIP, China Biology Medicine disc (CBMdisc), and references cited in related studies/reviews. Extracted data included the total effective rate, helicobacter pylori eradication rates, recurrence rate, and adverse reaction rate. Fifty-eight randomised controlled trials involving 5192 patients were included in the final analysis.

Results: Results showed that Jianzhong decoction therapy was more effective than conventional Western medicine therapy (total effective rate, odds ratio [OR] = 4.29, 95% confidence interval [CI]: 3.51–5.23, P = 0.000; helicobacter pylori eradication rates, OR =2.10, 95% CI: 1.69–2.61, P = 0.000; recurrence rate, OR =0.23, 95% CI: 0.18–0.29, P = 0.000; and adverse reaction rate, OR =0.20, 95% CI: 0.12–0.33, P = 0.000).

Conclusions: Jianzhong decoction increased the total effective rate and helicobacter pylori eradication rate, and lowered the recurrence and adverse reaction rates. The results of this study can be used as a guide for clinical treatment of peptic ulcers.

Electronic supplementary material: The online version of this article (doi:10.1186/s12906-017-1723-2) contains supplementary material, which is available to authorized users.

No MeSH data available.


Meta-analysis of Hp eradication rates about two groups
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Fig3: Meta-analysis of Hp eradication rates about two groups

Mentions: Outcome indicators involved in all studies included the total effective rate, recurrence rate, Hp eradication rate, and adverse reaction rate; of these, 50 studies have reported the total effective rate. The results of the fixed effects model combined with effect sizes showed that the difference between Jianzhong decoction and conventional WM alone was significant in treating PU (OR =4.29, 95% CI: 3.51–5.23, P < 0.001, I2 = 0.0%, P = 0.987; Fig. 2). Moreover, there were 24 studies reporting the Hp eradication rate and the results of fixed effects model combined with effect sizes showed a significant difference between Jianzhong decoction and conventional WM alone in treating PU (OR =2.10, 95% CI: 1.69–2.61, P < 0.001, I2 = 39.6%, P = 0.025; Fig. 3). There were 24 studies reporting the recurrence rate and the results of fixed effects model combined with effect sizes showed a significant difference between Jianzhong decoction and conventional WM alone in treating PU (OR =0.23, 95% CI: 0.18–0.29, P < 0.001, I2 = 0.0%, P = 0.639; Fig. 4). There were 19 studies reporting the adverse reactions and the results of fixed effects model combined with effect sizes showed a significant difference between Jianzhong decoction and conventional WM alone in treating PU (OR =0.20, 95% CI: 0.12–0.33, P < 0.001, I2 = 28.1%, P = 0.177; Fig. 5).Fig. 2


Efficacy and safety of Jianzhong decoction in treating peptic ulcers: a meta-analysis of 58 randomised controlled trials with 5192 patients
Meta-analysis of Hp eradication rates about two groups
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC5391578&req=5

Fig3: Meta-analysis of Hp eradication rates about two groups
Mentions: Outcome indicators involved in all studies included the total effective rate, recurrence rate, Hp eradication rate, and adverse reaction rate; of these, 50 studies have reported the total effective rate. The results of the fixed effects model combined with effect sizes showed that the difference between Jianzhong decoction and conventional WM alone was significant in treating PU (OR =4.29, 95% CI: 3.51–5.23, P < 0.001, I2 = 0.0%, P = 0.987; Fig. 2). Moreover, there were 24 studies reporting the Hp eradication rate and the results of fixed effects model combined with effect sizes showed a significant difference between Jianzhong decoction and conventional WM alone in treating PU (OR =2.10, 95% CI: 1.69–2.61, P < 0.001, I2 = 39.6%, P = 0.025; Fig. 3). There were 24 studies reporting the recurrence rate and the results of fixed effects model combined with effect sizes showed a significant difference between Jianzhong decoction and conventional WM alone in treating PU (OR =0.23, 95% CI: 0.18–0.29, P < 0.001, I2 = 0.0%, P = 0.639; Fig. 4). There were 19 studies reporting the adverse reactions and the results of fixed effects model combined with effect sizes showed a significant difference between Jianzhong decoction and conventional WM alone in treating PU (OR =0.20, 95% CI: 0.12–0.33, P < 0.001, I2 = 28.1%, P = 0.177; Fig. 5).Fig. 2

View Article: PubMed Central - PubMed

ABSTRACT

Background: Jianzhong decoction is widely used to treat peptic ulcers; however, due to lack of systematic evaluations, its clinical efficacy remains controversial. We performed meta-analysis to evaluate the efficacy and safety of Jianzhong decoction in treating peptic ulcers.

Methods: Studies were systematically retrieved from PubMed, Embase, Cochrane library, China National Knowledge Infrastructure, Wanfang Database, Chongqing VIP, China Biology Medicine disc (CBMdisc), and references cited in related studies/reviews. Extracted data included the total effective rate, helicobacter pylori eradication rates, recurrence rate, and adverse reaction rate. Fifty-eight randomised controlled trials involving 5192 patients were included in the final analysis.

Results: Results showed that Jianzhong decoction therapy was more effective than conventional Western medicine therapy (total effective rate, odds ratio [OR]&nbsp;=&nbsp;4.29, 95% confidence interval [CI]: 3.51&ndash;5.23, P&nbsp;=&nbsp;0.000; helicobacter pylori eradication rates, OR =2.10, 95% CI: 1.69&ndash;2.61, P&nbsp;=&nbsp;0.000; recurrence rate, OR =0.23, 95% CI: 0.18&ndash;0.29, P&nbsp;=&nbsp;0.000; and adverse reaction rate, OR =0.20, 95% CI: 0.12&ndash;0.33, P&nbsp;=&nbsp;0.000).

Conclusions: Jianzhong decoction increased the total effective rate and helicobacter pylori eradication rate, and lowered the recurrence and adverse reaction rates. The results of this study can be used as a guide for clinical treatment of peptic ulcers.

Electronic supplementary material: The online version of this article (doi:10.1186/s12906-017-1723-2) contains supplementary material, which is available to authorized users.

No MeSH data available.