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Effects of omega-3 fatty acids on patients undergoing surgery for gastrointestinal malignancy: a systematic review and meta-analysis

View Article: PubMed Central - PubMed

ABSTRACT

Background: Surgical resection remains the primary treatment for gastrointestinal (GI) malignancy including early-stage cancer. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have been reported to have beneficial clinical and immune-modulating effects in the prognosis of GI cancer patients undergoing surgery.

Methods: We searched PubMed, Embase, EBSCO-Medline, Cochrane Central Register of Controlled Trials (CENTRAL), CNKI and Wanfang to identify primary research reporting the effects of n-3 PUFAs compared with isocaloric nutrition on GI cancer patients who underwent surgery up to the end of June 30, 2016. Two authors independently reviewed and selected eligible randomized controlled trials (RCTs).

Results: A total of 9 RCTs (623 participants) were included. The n-3 PUFAs regime resulted in lower levels of C-reactive protein (CRP) (P < 0.05), interleukin-6 (IL-6) (P < 0.01), and higher levels of albumin (ALB), CD3+ T cells, CD4+ T cells and CD4+/CD8+ ratio (P < 0.05) compared with the isocaloric nutrition regime. However, there was no significant difference in the level of tumor necrosis factor-α (TNF-α) between the n-3 PUFAs regime and the isocaloric nutrition regime (P = 0.17). And the level of CD8 + T cells decreased compared with the isocaloric nutrition regime (P < 0.0001).

Conclusions: Our meta-analysis revealed that n-3 PUFAs are effective in improving the nutritional status and immune function of GI cancer patients undergoing surgery as they effectively enhance immunity and attenuate the inflammatory response.

No MeSH data available.


Meta-analysis of inflammation level. a Change in CRP between n-3 PUFAs and isocaloric nutrition: random-effects model. b Change in IL-6 between n-3 PUFAs and isocaloric nutrition: random-effects model. c Change in TNF-a between n-3 PUFAs and isocaloric nutrition: random-effects model. d Change in ALB between n-3 PUFAs and isocaloric nutrition: random-effects model
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Fig3: Meta-analysis of inflammation level. a Change in CRP between n-3 PUFAs and isocaloric nutrition: random-effects model. b Change in IL-6 between n-3 PUFAs and isocaloric nutrition: random-effects model. c Change in TNF-a between n-3 PUFAs and isocaloric nutrition: random-effects model. d Change in ALB between n-3 PUFAs and isocaloric nutrition: random-effects model

Mentions: CRP: We identified 5 eligible trials, which included 269 patients, and investigated peripheral blood CRP levels following postoperative n-3 PUFAs supplementation versus isocaloric nutrition. The homogeneous test detected no statistical heterogeneity (P = 0.12), therefore, we adopted a fixed-effects model to perform the analysis. The meta-analysis revealed that n-3 PUFAs effectively decreased the level of CRP (P < 0.05) (Fig. 3).Fig. 3


Effects of omega-3 fatty acids on patients undergoing surgery for gastrointestinal malignancy: a systematic review and meta-analysis
Meta-analysis of inflammation level. a Change in CRP between n-3 PUFAs and isocaloric nutrition: random-effects model. b Change in IL-6 between n-3 PUFAs and isocaloric nutrition: random-effects model. c Change in TNF-a between n-3 PUFAs and isocaloric nutrition: random-effects model. d Change in ALB between n-3 PUFAs and isocaloric nutrition: random-effects model
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC5391568&req=5

Fig3: Meta-analysis of inflammation level. a Change in CRP between n-3 PUFAs and isocaloric nutrition: random-effects model. b Change in IL-6 between n-3 PUFAs and isocaloric nutrition: random-effects model. c Change in TNF-a between n-3 PUFAs and isocaloric nutrition: random-effects model. d Change in ALB between n-3 PUFAs and isocaloric nutrition: random-effects model
Mentions: CRP: We identified 5 eligible trials, which included 269 patients, and investigated peripheral blood CRP levels following postoperative n-3 PUFAs supplementation versus isocaloric nutrition. The homogeneous test detected no statistical heterogeneity (P = 0.12), therefore, we adopted a fixed-effects model to perform the analysis. The meta-analysis revealed that n-3 PUFAs effectively decreased the level of CRP (P < 0.05) (Fig. 3).Fig. 3

View Article: PubMed Central - PubMed

ABSTRACT

Background: Surgical resection remains the primary treatment for gastrointestinal (GI) malignancy including early-stage cancer. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have been reported to have beneficial clinical and immune-modulating effects in the prognosis of GI cancer patients undergoing surgery.

Methods: We searched PubMed, Embase, EBSCO-Medline, Cochrane Central Register of Controlled Trials (CENTRAL), CNKI and Wanfang to identify primary research reporting the effects of n-3 PUFAs compared with isocaloric nutrition on GI cancer patients who underwent surgery up to the end of June 30, 2016. Two authors independently reviewed and selected eligible randomized controlled trials (RCTs).

Results: A total of 9 RCTs (623 participants) were included. The n-3 PUFAs regime resulted in lower levels of C-reactive protein (CRP) (P&nbsp;&lt;&nbsp;0.05), interleukin-6 (IL-6) (P&nbsp;&lt;&nbsp;0.01), and higher levels of albumin (ALB), CD3+ T cells, CD4+ T cells and CD4+/CD8+ ratio (P&nbsp;&lt;&nbsp;0.05) compared with the isocaloric nutrition regime. However, there was no significant difference in the level of tumor necrosis factor-&alpha; (TNF-&alpha;) between the n-3 PUFAs regime and the isocaloric nutrition regime (P&nbsp;=&nbsp;0.17). And the level of CD8 + T cells decreased compared with the isocaloric nutrition regime (P&nbsp;&lt;&nbsp;0.0001).

Conclusions: Our meta-analysis revealed that n-3 PUFAs are effective in improving the nutritional status and immune function of GI cancer patients undergoing surgery as they effectively enhance immunity and attenuate the inflammatory response.

No MeSH data available.