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Effects of omega-3 fatty acids on patients undergoing surgery for gastrointestinal malignancy: a systematic review and meta-analysis

View Article: PubMed Central - PubMed

ABSTRACT

Background: Surgical resection remains the primary treatment for gastrointestinal (GI) malignancy including early-stage cancer. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have been reported to have beneficial clinical and immune-modulating effects in the prognosis of GI cancer patients undergoing surgery.

Methods: We searched PubMed, Embase, EBSCO-Medline, Cochrane Central Register of Controlled Trials (CENTRAL), CNKI and Wanfang to identify primary research reporting the effects of n-3 PUFAs compared with isocaloric nutrition on GI cancer patients who underwent surgery up to the end of June 30, 2016. Two authors independently reviewed and selected eligible randomized controlled trials (RCTs).

Results: A total of 9 RCTs (623 participants) were included. The n-3 PUFAs regime resulted in lower levels of C-reactive protein (CRP) (P < 0.05), interleukin-6 (IL-6) (P < 0.01), and higher levels of albumin (ALB), CD3+ T cells, CD4+ T cells and CD4+/CD8+ ratio (P < 0.05) compared with the isocaloric nutrition regime. However, there was no significant difference in the level of tumor necrosis factor-α (TNF-α) between the n-3 PUFAs regime and the isocaloric nutrition regime (P = 0.17). And the level of CD8 + T cells decreased compared with the isocaloric nutrition regime (P < 0.0001).

Conclusions: Our meta-analysis revealed that n-3 PUFAs are effective in improving the nutritional status and immune function of GI cancer patients undergoing surgery as they effectively enhance immunity and attenuate the inflammatory response.

No MeSH data available.


Flowchart of computerized search and the eligible studies included in this systematic review and meta-analysis
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Fig1: Flowchart of computerized search and the eligible studies included in this systematic review and meta-analysis

Mentions: The electronic literature search yielded 672 potential studies for inclusion. And finally, 126 articles had titles and abstracts that appeared to be potentially relevant. Of these studies, 54 studies were excluded because the patients received arginine. 8 studies were reported neither in Chinese nor in English and were thus excluded; 55 studies with full texts were further excluded as the patients received chemotherapy. All procedures were performed by two investigators independently. In total, 9 eligible studies were included in this meta-analysis. The flow chart of retrieval and selection of the studies is shown in Fig. 1.Fig. 1


Effects of omega-3 fatty acids on patients undergoing surgery for gastrointestinal malignancy: a systematic review and meta-analysis
Flowchart of computerized search and the eligible studies included in this systematic review and meta-analysis
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC5391568&req=5

Fig1: Flowchart of computerized search and the eligible studies included in this systematic review and meta-analysis
Mentions: The electronic literature search yielded 672 potential studies for inclusion. And finally, 126 articles had titles and abstracts that appeared to be potentially relevant. Of these studies, 54 studies were excluded because the patients received arginine. 8 studies were reported neither in Chinese nor in English and were thus excluded; 55 studies with full texts were further excluded as the patients received chemotherapy. All procedures were performed by two investigators independently. In total, 9 eligible studies were included in this meta-analysis. The flow chart of retrieval and selection of the studies is shown in Fig. 1.Fig. 1

View Article: PubMed Central - PubMed

ABSTRACT

Background: Surgical resection remains the primary treatment for gastrointestinal (GI) malignancy including early-stage cancer. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have been reported to have beneficial clinical and immune-modulating effects in the prognosis of GI cancer patients undergoing surgery.

Methods: We searched PubMed, Embase, EBSCO-Medline, Cochrane Central Register of Controlled Trials (CENTRAL), CNKI and Wanfang to identify primary research reporting the effects of n-3 PUFAs compared with isocaloric nutrition on GI cancer patients who underwent surgery up to the end of June 30, 2016. Two authors independently reviewed and selected eligible randomized controlled trials (RCTs).

Results: A total of 9 RCTs (623 participants) were included. The n-3 PUFAs regime resulted in lower levels of C-reactive protein (CRP) (P < 0.05), interleukin-6 (IL-6) (P < 0.01), and higher levels of albumin (ALB), CD3+ T cells, CD4+ T cells and CD4+/CD8+ ratio (P < 0.05) compared with the isocaloric nutrition regime. However, there was no significant difference in the level of tumor necrosis factor-α (TNF-α) between the n-3 PUFAs regime and the isocaloric nutrition regime (P = 0.17). And the level of CD8 + T cells decreased compared with the isocaloric nutrition regime (P < 0.0001).

Conclusions: Our meta-analysis revealed that n-3 PUFAs are effective in improving the nutritional status and immune function of GI cancer patients undergoing surgery as they effectively enhance immunity and attenuate the inflammatory response.

No MeSH data available.