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Resveratrol regulates body weight in healthy and ovariectomized rats

View Article: PubMed Central - PubMed

ABSTRACT

Objective: The elevated body weight in post-menopausal state attributes to the reduced estrogen levels which is alleviated by resveratrol (RES) but its role in control rats is not well understood. The main objective of the study was to explore the effects of RES on the body weight of ovariectomized (OVX) female rats with controls and to relate their biochemical parameters.

Methods: Female Wistar rats weighing 200–300 g underwent bilateral ovariectomy (OVX) and were fed soya free diet (n = 8 rats per group). In all groups: (Control, Control + Resveratrol, OVX and OVX + Resveratrol) resveratrol was administered orally at a dose of 5 mg/kg/day for 1 month. Glucose and other biochemical parameters were examined.

Results: Significant reduction in the gain of body weight was observed in the control rats treated with resveratrol. Ovariectomy caused an escalation in gain of body weight due to loss of estrogen which was brought down with resveratrol. There was a slight dip in the blood glucose levels after resveratrol treatment.

Conclusion: Resveratrol significantly reduced the gain of body weight in the control rats and in OVX rats showing its antiobesogenic effects.

No MeSH data available.


Effect of resveratrol on (a) Urea, (b) Creatinine, (c) Triglycerides (TG), (d) Cholestrol, (e) High density lipoprotein (HDL), (f) Low density lipoprotein (LDL) in control, control + Res, OVX and OVX + Res rats
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Fig4: Effect of resveratrol on (a) Urea, (b) Creatinine, (c) Triglycerides (TG), (d) Cholestrol, (e) High density lipoprotein (HDL), (f) Low density lipoprotein (LDL) in control, control + Res, OVX and OVX + Res rats

Mentions: Blood glucose levels of control, ovariectomized groups and their respective resveratrol treated groups were estimated at necropsy and we found a slight decrease in the glucose levels of the OVX rats treated with resveratrol though the change was not significant (p > 0.05) while no change was found in the control rats treated with resveratrol Fig. 3b. Resveratrol treatment brought about a slight decrease in the urea levels of the control rats though the change was not significant (p > 0.05) Fig. 4a. While the mean serum creatinine was within the normal range in all the animals it was lower in all the experimental groups compared to the control and resveratrol treated control group. Resveratrol treatment led to decrease in the creatinine levels in the control rats though the change was not significant (p > 0.05) Fig. 4b. A significant increase in the mean TG levels was observed in the control + RES rats in comparison to control rats (p < 0.05). Resveratrol brought about a small decrease in the TG levels of the OVX (p > 0.05) group though the change was not significant (p > 0.05) (Fig. 4c. Significant increase in the cholesterol levels was observed in the OVX rats (p < 0.001) in comparison to the control rats Fig. 4d. Resveratrol treatment brought about a decrease in the cholesterol levels of the control and OVX rats though the change was not significant (p < 0.05). A slight decrease was observed in the HDL levels of the control and OVX rats upon resveratrol treatment though the change was not significant (p > 0.05) Fig. 4e. A slight decrease in the LDL levels was observed in the control and OVX rats upon resveratrol treatment though the change was not significant (p > 0.05) Fig. 4f.Fig. 4


Resveratrol regulates body weight in healthy and ovariectomized rats
Effect of resveratrol on (a) Urea, (b) Creatinine, (c) Triglycerides (TG), (d) Cholestrol, (e) High density lipoprotein (HDL), (f) Low density lipoprotein (LDL) in control, control + Res, OVX and OVX + Res rats
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Related In: Results  -  Collection

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getmorefigures.php?uid=PMC5391549&req=5

Fig4: Effect of resveratrol on (a) Urea, (b) Creatinine, (c) Triglycerides (TG), (d) Cholestrol, (e) High density lipoprotein (HDL), (f) Low density lipoprotein (LDL) in control, control + Res, OVX and OVX + Res rats
Mentions: Blood glucose levels of control, ovariectomized groups and their respective resveratrol treated groups were estimated at necropsy and we found a slight decrease in the glucose levels of the OVX rats treated with resveratrol though the change was not significant (p > 0.05) while no change was found in the control rats treated with resveratrol Fig. 3b. Resveratrol treatment brought about a slight decrease in the urea levels of the control rats though the change was not significant (p > 0.05) Fig. 4a. While the mean serum creatinine was within the normal range in all the animals it was lower in all the experimental groups compared to the control and resveratrol treated control group. Resveratrol treatment led to decrease in the creatinine levels in the control rats though the change was not significant (p > 0.05) Fig. 4b. A significant increase in the mean TG levels was observed in the control + RES rats in comparison to control rats (p < 0.05). Resveratrol brought about a small decrease in the TG levels of the OVX (p > 0.05) group though the change was not significant (p > 0.05) (Fig. 4c. Significant increase in the cholesterol levels was observed in the OVX rats (p < 0.001) in comparison to the control rats Fig. 4d. Resveratrol treatment brought about a decrease in the cholesterol levels of the control and OVX rats though the change was not significant (p < 0.05). A slight decrease was observed in the HDL levels of the control and OVX rats upon resveratrol treatment though the change was not significant (p > 0.05) Fig. 4e. A slight decrease in the LDL levels was observed in the control and OVX rats upon resveratrol treatment though the change was not significant (p > 0.05) Fig. 4f.Fig. 4

View Article: PubMed Central - PubMed

ABSTRACT

Objective: The elevated body weight in post-menopausal state attributes to the reduced estrogen levels which is alleviated by resveratrol (RES) but its role in control rats is not well understood. The main objective of the study was to explore the effects of RES on the body weight of ovariectomized (OVX) female rats with controls and to relate their biochemical parameters.

Methods: Female Wistar rats weighing 200&ndash;300&nbsp;g underwent bilateral ovariectomy (OVX) and were fed soya free diet (n&thinsp;=&thinsp;8 rats per group). In all groups: (Control, Control&thinsp;+&thinsp;Resveratrol, OVX and OVX&thinsp;+&thinsp;Resveratrol) resveratrol was administered orally at a dose of 5&nbsp;mg/kg/day for 1&nbsp;month. Glucose and other biochemical parameters were examined.

Results: Significant reduction in the gain of body weight was observed in the control rats treated with resveratrol. Ovariectomy caused an escalation in gain of body weight due to loss of estrogen which was brought down with resveratrol. There was a slight dip in the blood glucose levels after resveratrol treatment.

Conclusion: Resveratrol significantly reduced the gain of body weight in the control rats and in OVX rats showing its antiobesogenic effects.

No MeSH data available.