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Dissociable neural processes during risky decision-making in individuals with Internet-gaming disorder ☆

View Article: PubMed Central - PubMed

ABSTRACT

Risk-taking is purported to be central to addictive behaviors. However, for Internet gaming disorder (IGD), a condition conceptualized as a behavioral addiction, the neural processes underlying impaired decision-making (risk evaluation and outcome processing) related to gains and losses have not been systematically investigated. Forty-one males with IGD and 27 healthy comparison (HC) male participants were recruited, and the cups task was used to identify neural processes associated with gain- and loss-related risk- and outcome-processing in IGD. During risk evaluation, the IGD group, compared to the HC participants, showed weaker modulation for experienced risk within the bilateral dorsolateral prefrontal cortex (DLPFC) (t = − 4.07; t = − 3.94; PFWE < 0.05) and inferior parietal lobule (IPL) (t = − 4.08; t = − 4.08; PFWE < 0.05) for potential losses. The modulation of the left DLPFC and bilateral IPL activation were negatively related to addiction severity within the IGD group (r = − 0.55; r = − 0.61; r = − 0.51; PFWE < 0.05). During outcome processing, the IGD group presented greater responses for the experienced reward within the ventral striatum, ventromedial prefrontal cortex, and orbitofrontal cortex (OFC) (t = 5.04, PFWE < 0.05) for potential gains, as compared to HC participants. Within the IGD group, the increased reward-related activity in the right OFC was positively associated with severity of IGD (r = 0.51, PFWE < 0.05). These results provide a neurobiological foundation for decision-making deficits in individuals with IGD and suggest an imbalance between hypersensitivity for reward and weaker risk experience and self-control for loss. The findings suggest a biological mechanism for why individuals with IGD may persist in game-seeking behavior despite negative consequences, and treatment development strategies may focus on targeting these neural pathways in this population.

No MeSH data available.


Related in: MedlinePlus

Group differences in fMRI findings using parametric (panel A and B) and categorical analysis (panel C and D). Group differences of sensitivity to experienced risk under loss conditions (A) and experienced reward (B) are displayed. Group differences of participants' responses to risky versus safe for potential losses (C) and to win versus loss for potential gains (D) are displayed. The color bars reflect t values. The 2D activation maps are overlaid on a T1 image using DPABI. (voxel-level P < 0.005 and cluster-level of P < 0.05, whole-brain corrected). (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)
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f0010: Group differences in fMRI findings using parametric (panel A and B) and categorical analysis (panel C and D). Group differences of sensitivity to experienced risk under loss conditions (A) and experienced reward (B) are displayed. Group differences of participants' responses to risky versus safe for potential losses (C) and to win versus loss for potential gains (D) are displayed. The color bars reflect t values. The 2D activation maps are overlaid on a T1 image using DPABI. (voxel-level P < 0.005 and cluster-level of P < 0.05, whole-brain corrected). (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)

Mentions: Whole-brain-corrected group comparisons of the parametric analysis for experienced risk revealed decreased modulation of bilateral DLPFC (MNI: − 42, 54, 18, t = − 4.07; MNI: 33, 21, 51, t = − 3.94) and IPL (MNI: − 45, − 54, 48, t = − 4.08; MNI: 33, − 63, 57, t = − 4.08) in IGD participants compared to the HC group (Fig. 2A and Table 2). That is, there was a weaker relationship between activation of the identified brain regions (DLPFC, IPL) and the experimental parameter (experienced risk) in the IGD as compared to the HC group.


Dissociable neural processes during risky decision-making in individuals with Internet-gaming disorder ☆
Group differences in fMRI findings using parametric (panel A and B) and categorical analysis (panel C and D). Group differences of sensitivity to experienced risk under loss conditions (A) and experienced reward (B) are displayed. Group differences of participants' responses to risky versus safe for potential losses (C) and to win versus loss for potential gains (D) are displayed. The color bars reflect t values. The 2D activation maps are overlaid on a T1 image using DPABI. (voxel-level P < 0.005 and cluster-level of P < 0.05, whole-brain corrected). (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5385591&req=5

f0010: Group differences in fMRI findings using parametric (panel A and B) and categorical analysis (panel C and D). Group differences of sensitivity to experienced risk under loss conditions (A) and experienced reward (B) are displayed. Group differences of participants' responses to risky versus safe for potential losses (C) and to win versus loss for potential gains (D) are displayed. The color bars reflect t values. The 2D activation maps are overlaid on a T1 image using DPABI. (voxel-level P < 0.005 and cluster-level of P < 0.05, whole-brain corrected). (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)
Mentions: Whole-brain-corrected group comparisons of the parametric analysis for experienced risk revealed decreased modulation of bilateral DLPFC (MNI: − 42, 54, 18, t = − 4.07; MNI: 33, 21, 51, t = − 3.94) and IPL (MNI: − 45, − 54, 48, t = − 4.08; MNI: 33, − 63, 57, t = − 4.08) in IGD participants compared to the HC group (Fig. 2A and Table 2). That is, there was a weaker relationship between activation of the identified brain regions (DLPFC, IPL) and the experimental parameter (experienced risk) in the IGD as compared to the HC group.

View Article: PubMed Central - PubMed

ABSTRACT

Risk-taking is purported to be central to addictive behaviors. However, for Internet gaming disorder (IGD), a condition conceptualized as a behavioral addiction, the neural processes underlying impaired decision-making (risk evaluation and outcome processing) related to gains and losses have not been systematically investigated. Forty-one males with IGD and 27 healthy comparison (HC) male participants were recruited, and the cups task was used to identify neural processes associated with gain- and loss-related risk- and outcome-processing in IGD. During risk evaluation, the IGD group, compared to the HC participants, showed weaker modulation for experienced risk within the bilateral dorsolateral prefrontal cortex (DLPFC) (t&nbsp;=&nbsp;&minus;&nbsp;4.07; t&nbsp;=&nbsp;&minus;&nbsp;3.94; PFWE&nbsp;&lt;&nbsp;0.05) and inferior parietal lobule (IPL) (t&nbsp;=&nbsp;&minus;&nbsp;4.08; t&nbsp;=&nbsp;&minus;&nbsp;4.08; PFWE&nbsp;&lt;&nbsp;0.05) for potential losses. The modulation of the left DLPFC and bilateral IPL activation were negatively related to addiction severity within the IGD group (r&nbsp;=&nbsp;&minus;&nbsp;0.55; r&nbsp;=&nbsp;&minus;&nbsp;0.61; r&nbsp;=&nbsp;&minus;&nbsp;0.51; PFWE&nbsp;&lt;&nbsp;0.05). During outcome processing, the IGD group presented greater responses for the experienced reward within the ventral striatum, ventromedial prefrontal cortex, and orbitofrontal cortex (OFC) (t&nbsp;=&nbsp;5.04, PFWE&nbsp;&lt;&nbsp;0.05) for potential gains, as compared to HC participants. Within the IGD group, the increased reward-related activity in the right OFC was positively associated with severity of IGD (r&nbsp;=&nbsp;0.51, PFWE&nbsp;&lt;&nbsp;0.05). These results provide a neurobiological foundation for decision-making deficits in individuals with IGD and suggest an imbalance between hypersensitivity for reward and weaker risk experience and self-control for loss. The findings suggest a biological mechanism for why individuals with IGD may persist in game-seeking behavior despite negative consequences, and treatment development strategies may focus on targeting these neural pathways in this population.

No MeSH data available.


Related in: MedlinePlus