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Sunitinib Enables a Clinical and Pathological Complete Remission of Metastatic Renal Cell Carcinoma (mRCC)

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ABSTRACT

Renal cell carcinoma (RCC) is the most common renal cancer, and has a poor prognosis in individuals with metastases (mRCC). In this report, we describe a 48-year-old woman with unresectable multiple liver metastases and a colonic metastasis of RCC who was treated with sunitinib in combination with hepatic microwave ablation and obtained a clinical and pathological complete remission. We consider that sunitinib combined with microwave ablation can prevent unresectable hepatic metastases of RCC from evolving, and that sunitinib alone can achieve clinical and pathological remission in patients with colonic metastasis of RCC.

No MeSH data available.


Related in: MedlinePlus

(A, B, and C) Percutaneous liver biopsy showed inflammatory granulation tissue and purulent necrosis, in which diffuse distribution or adenoid arrangement of atypical cells was observed. The cells had large nuclei, were trachychromatic, and abundant in plasma. Immunohistochemical analytical data showed CK8(+), CEA(−), and Mac387(−), indicating a liver metastasis of the RCC.
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fig2: (A, B, and C) Percutaneous liver biopsy showed inflammatory granulation tissue and purulent necrosis, in which diffuse distribution or adenoid arrangement of atypical cells was observed. The cells had large nuclei, were trachychromatic, and abundant in plasma. Immunohistochemical analytical data showed CK8(+), CEA(−), and Mac387(−), indicating a liver metastasis of the RCC.

Mentions: A 48-year-old Chinese woman who was diagnosed with right RCC underwent a right radical nephrectomy in 2007. The pathological report indicated clear-cell carcinoma of the kidney. Three years later, she presented with recurrent upper abdominal pain and an abdominal ultrasound scan indicated cholecystitis and gall bladder stones. She was therefore referred to our hospital for treatment on 30 July, 2010. As a computed tomography (CT) scan and plain abdominal radiograph showed subdiaphragmatic free air as the aggravating abdominal symptom, she received an exploratory laparotomy. During this procedure, a hepatic flexure colonic mass adhering to the surrounding tissue was observed. This was considered to be a metastasis of RCC, and it resulted in intestinal perforation. This diagnosis was confirmed by a positron emission-computed tomography (PET-CT) scan (Fig. 1). As the lesion was too firm to be removed, an ileostomy was performed at right lower quadrant of abdomen. Subsequently, the patient was started on sunitinib therapy which was administered at the recommended dosage of 50 mg daily in a 4/2 schedule (4 weeks on therapy followed by 2 weeks off therapy). Five months later, the patient was admitted to our department because of fever. A CT scan showed multiple low-density shadows in the liver, and a percutaneous liver biopsy indicated metastases of RCC (Fig. 2).


Sunitinib Enables a Clinical and Pathological Complete Remission of Metastatic Renal Cell Carcinoma (mRCC)
(A, B, and C) Percutaneous liver biopsy showed inflammatory granulation tissue and purulent necrosis, in which diffuse distribution or adenoid arrangement of atypical cells was observed. The cells had large nuclei, were trachychromatic, and abundant in plasma. Immunohistochemical analytical data showed CK8(+), CEA(−), and Mac387(−), indicating a liver metastasis of the RCC.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5385577&req=5

fig2: (A, B, and C) Percutaneous liver biopsy showed inflammatory granulation tissue and purulent necrosis, in which diffuse distribution or adenoid arrangement of atypical cells was observed. The cells had large nuclei, were trachychromatic, and abundant in plasma. Immunohistochemical analytical data showed CK8(+), CEA(−), and Mac387(−), indicating a liver metastasis of the RCC.
Mentions: A 48-year-old Chinese woman who was diagnosed with right RCC underwent a right radical nephrectomy in 2007. The pathological report indicated clear-cell carcinoma of the kidney. Three years later, she presented with recurrent upper abdominal pain and an abdominal ultrasound scan indicated cholecystitis and gall bladder stones. She was therefore referred to our hospital for treatment on 30 July, 2010. As a computed tomography (CT) scan and plain abdominal radiograph showed subdiaphragmatic free air as the aggravating abdominal symptom, she received an exploratory laparotomy. During this procedure, a hepatic flexure colonic mass adhering to the surrounding tissue was observed. This was considered to be a metastasis of RCC, and it resulted in intestinal perforation. This diagnosis was confirmed by a positron emission-computed tomography (PET-CT) scan (Fig. 1). As the lesion was too firm to be removed, an ileostomy was performed at right lower quadrant of abdomen. Subsequently, the patient was started on sunitinib therapy which was administered at the recommended dosage of 50 mg daily in a 4/2 schedule (4 weeks on therapy followed by 2 weeks off therapy). Five months later, the patient was admitted to our department because of fever. A CT scan showed multiple low-density shadows in the liver, and a percutaneous liver biopsy indicated metastases of RCC (Fig. 2).

View Article: PubMed Central - PubMed

ABSTRACT

Renal cell carcinoma (RCC) is the most common renal cancer, and has a poor prognosis in individuals with metastases (mRCC). In this report, we describe a 48-year-old woman with unresectable multiple liver metastases and a colonic metastasis of RCC who was treated with sunitinib in combination with hepatic microwave ablation and obtained a clinical and pathological complete remission. We consider that sunitinib combined with microwave ablation can prevent unresectable hepatic metastases of RCC from evolving, and that sunitinib alone can achieve clinical and pathological remission in patients with colonic metastasis of RCC.

No MeSH data available.


Related in: MedlinePlus