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The role of mast cells in oral squamous cell carcinoma

View Article: PubMed Central - PubMed

ABSTRACT

The mast cells are initial effective lineage in both humoral and adaptive immunity. They are ubiquitous in skin, mucosa, and in function. They contain biologically essential and dynamic mediators in healthy and harmful conditions of tissue. Mast cell malfunctioning could be attributed to various chronic allergic diseases. Considerately, emerging evidence of mast cell involvement in various cancers shows them to have both positive and negative roles in tumour growth. It mostly indulges in tumour progression and metastasis via angiogenesis, extracellular matrix degradation, and mitogenic activity in the tumour microenvironment. The current paper reviewed research papers on mast cells in oral squamous cell carcinoma through the PubMed database from 1980 to the present date. The present paper is an attempt to summarise the research reports on the role of mast cells in oral squamous cell carcinoma. Further to this note, this paper also outlines the role of mast cells in normal physiological processes and tumour biology.

No MeSH data available.


Over all activity of mast cells
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Mentions: Nonetheless, it has been observed that mast cells can also be activated via other pathways and extrinsic signals. These ‘alternate pathways’ are thought to play an important role in infiltration in tumours (Fig. 2). Another important aspect of mast cells recently discovered is their ability to change their phenotype according the site and the duration of stimuli to which they are exposed. This is termed ‘mast cell plasticity’ [15, 16]. Mast cells have a long life and form a heterogeneous population of cells that seem to have both a positive and negative regulatory effect on the immune system. They participate in both innate as well as adaptive immunity. The physiological function of mast cells in epithelium, endothelium, and the nervous system is immune modulatory. They are ubiquitous in taking part in maintaining homeostasis of the body [17, 18]. The mediators induce microbial clearance, debris removal, wound contraction, keratinisation, and proliferation of epithelial cells and fibroblasts. Communication among mast cells and the nervous system ensues through the synaptic-like assemblies via adhesion molecules such as N cadherin or synCAM [4].


The role of mast cells in oral squamous cell carcinoma
Over all activity of mast cells
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5385471&req=5

f0002: Over all activity of mast cells
Mentions: Nonetheless, it has been observed that mast cells can also be activated via other pathways and extrinsic signals. These ‘alternate pathways’ are thought to play an important role in infiltration in tumours (Fig. 2). Another important aspect of mast cells recently discovered is their ability to change their phenotype according the site and the duration of stimuli to which they are exposed. This is termed ‘mast cell plasticity’ [15, 16]. Mast cells have a long life and form a heterogeneous population of cells that seem to have both a positive and negative regulatory effect on the immune system. They participate in both innate as well as adaptive immunity. The physiological function of mast cells in epithelium, endothelium, and the nervous system is immune modulatory. They are ubiquitous in taking part in maintaining homeostasis of the body [17, 18]. The mediators induce microbial clearance, debris removal, wound contraction, keratinisation, and proliferation of epithelial cells and fibroblasts. Communication among mast cells and the nervous system ensues through the synaptic-like assemblies via adhesion molecules such as N cadherin or synCAM [4].

View Article: PubMed Central - PubMed

ABSTRACT

The mast cells are initial effective lineage in both humoral and adaptive immunity. They are ubiquitous in skin, mucosa, and in function. They contain biologically essential and dynamic mediators in healthy and harmful conditions of tissue. Mast cell malfunctioning could be attributed to various chronic allergic diseases. Considerately, emerging evidence of mast cell involvement in various cancers shows them to have both positive and negative roles in tumour growth. It mostly indulges in tumour progression and metastasis via angiogenesis, extracellular matrix degradation, and mitogenic activity in the tumour microenvironment. The current paper reviewed research papers on mast cells in oral squamous cell carcinoma through the PubMed database from 1980 to the present date. The present paper is an attempt to summarise the research reports on the role of mast cells in oral squamous cell carcinoma. Further to this note, this paper also outlines the role of mast cells in normal physiological processes and tumour biology.

No MeSH data available.