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The role of mast cells in oral squamous cell carcinoma

View Article: PubMed Central - PubMed

ABSTRACT

The mast cells are initial effective lineage in both humoral and adaptive immunity. They are ubiquitous in skin, mucosa, and in function. They contain biologically essential and dynamic mediators in healthy and harmful conditions of tissue. Mast cell malfunctioning could be attributed to various chronic allergic diseases. Considerately, emerging evidence of mast cell involvement in various cancers shows them to have both positive and negative roles in tumour growth. It mostly indulges in tumour progression and metastasis via angiogenesis, extracellular matrix degradation, and mitogenic activity in the tumour microenvironment. The current paper reviewed research papers on mast cells in oral squamous cell carcinoma through the PubMed database from 1980 to the present date. The present paper is an attempt to summarise the research reports on the role of mast cells in oral squamous cell carcinoma. Further to this note, this paper also outlines the role of mast cells in normal physiological processes and tumour biology.

No MeSH data available.


Related in: MedlinePlus

Mast cells vesicles, granules and receptors
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f0001: Mast cells vesicles, granules and receptors

Mentions: This entire process is umpired by three mechanisms. Firstly by release of granules – exocytosis – which helps to increase vascular permeability, stimulates smooth muscle contraction, and degrades microbial substances, tissue damage, and remodelling [13] (Fig. 1). The second mechanism is secretion of lipid mediators – performing functions like vasodilatation, bronchoconstriction, neutrophil chemotaxis, mucous secretion, and increasing vascular permeability. The last mechanism is biosynthesis and secretion of cytokines, which promotes mast cell proliferation, inflammation, late phase reaction, Th2 cell differentiation, eosinophil production, and activation. These events in turn will be controlled by different mechanisms. Mast cells correspondingly express receptors for numerous components of complement system like CR3, CR4, and CR5 [14].


The role of mast cells in oral squamous cell carcinoma
Mast cells vesicles, granules and receptors
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5385471&req=5

f0001: Mast cells vesicles, granules and receptors
Mentions: This entire process is umpired by three mechanisms. Firstly by release of granules – exocytosis – which helps to increase vascular permeability, stimulates smooth muscle contraction, and degrades microbial substances, tissue damage, and remodelling [13] (Fig. 1). The second mechanism is secretion of lipid mediators – performing functions like vasodilatation, bronchoconstriction, neutrophil chemotaxis, mucous secretion, and increasing vascular permeability. The last mechanism is biosynthesis and secretion of cytokines, which promotes mast cell proliferation, inflammation, late phase reaction, Th2 cell differentiation, eosinophil production, and activation. These events in turn will be controlled by different mechanisms. Mast cells correspondingly express receptors for numerous components of complement system like CR3, CR4, and CR5 [14].

View Article: PubMed Central - PubMed

ABSTRACT

The mast cells are initial effective lineage in both humoral and adaptive immunity. They are ubiquitous in skin, mucosa, and in function. They contain biologically essential and dynamic mediators in healthy and harmful conditions of tissue. Mast cell malfunctioning could be attributed to various chronic allergic diseases. Considerately, emerging evidence of mast cell involvement in various cancers shows them to have both positive and negative roles in tumour growth. It mostly indulges in tumour progression and metastasis via angiogenesis, extracellular matrix degradation, and mitogenic activity in the tumour microenvironment. The current paper reviewed research papers on mast cells in oral squamous cell carcinoma through the PubMed database from 1980 to the present date. The present paper is an attempt to summarise the research reports on the role of mast cells in oral squamous cell carcinoma. Further to this note, this paper also outlines the role of mast cells in normal physiological processes and tumour biology.

No MeSH data available.


Related in: MedlinePlus