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Influence of time interval from diagnosis to treatment on survival for oral cavity cancer: A nationwide cohort study

View Article: PubMed Central - PubMed

ABSTRACT

Objectives: We aimed to explore the relationship between the time interval from diagnosis to treatment and survival of oral cavity squamous cell carcinoma patients.

Materials and methods: A population-based study was conducted between 2004 and 2010. Claims data of oral squamous cell carcinoma patients were retrieved from the Taiwan Cancer Registry Database. Secondary data were obtained from Taiwan’s National Health Insurance Research Database.

Results: A total of 21,263 patients were included in the final analysis. The majority of the patients received treatment within 30 days of diagnosis (n = 18,193, 85.5%), while 572 patients (2.7%) underwent treatment after 120 days. The patients who were treated after 120 days had a higher risk of death when compared to those treated within 30 days (Hazard ratio: 1.32, 95% Confidence intervals: 1.19 to 1.47).

Conclusion: A longer time interval from diagnosis to treatment was found to be associated with a poorer prognosis among patients suffering from oral squamous cell carcinoma.

No MeSH data available.


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Overall survival curves of oral cavity squamous cell carcinoma patients stratified by different time intervals from diagnosis to treatment.
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pone.0175148.g001: Overall survival curves of oral cavity squamous cell carcinoma patients stratified by different time intervals from diagnosis to treatment.

Mentions: Using the Kaplan-Meier method, patients treated after 30 days from diagnosis had a lower overall survival rate when compared with those treated within 30 days (Fig 1). If we stratified the patients according to their initial tumor stage, the time interval from diagnosis to treatment remained a significant prognosticator (Fig 2). When compared with those treated within 30 days, patients treated after 120 days from diagnosis had a 1.32-fold increased risk of death (95% confidence interval: 1.19–1.47). Male gender, older age, other catastrophic illness/injury, late-stage diseases, low income, treated initially with radiotherapy/chemotherapy, higher CCI, or treated in private/low service volume hospitals were associated with a poorer prognosis. Detailed data are shown in Table 3.


Influence of time interval from diagnosis to treatment on survival for oral cavity cancer: A nationwide cohort study
Overall survival curves of oral cavity squamous cell carcinoma patients stratified by different time intervals from diagnosis to treatment.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5384671&req=5

pone.0175148.g001: Overall survival curves of oral cavity squamous cell carcinoma patients stratified by different time intervals from diagnosis to treatment.
Mentions: Using the Kaplan-Meier method, patients treated after 30 days from diagnosis had a lower overall survival rate when compared with those treated within 30 days (Fig 1). If we stratified the patients according to their initial tumor stage, the time interval from diagnosis to treatment remained a significant prognosticator (Fig 2). When compared with those treated within 30 days, patients treated after 120 days from diagnosis had a 1.32-fold increased risk of death (95% confidence interval: 1.19–1.47). Male gender, older age, other catastrophic illness/injury, late-stage diseases, low income, treated initially with radiotherapy/chemotherapy, higher CCI, or treated in private/low service volume hospitals were associated with a poorer prognosis. Detailed data are shown in Table 3.

View Article: PubMed Central - PubMed

ABSTRACT

Objectives: We aimed to explore the relationship between the time interval from diagnosis to treatment and survival of oral cavity squamous cell carcinoma patients.

Materials and methods: A population-based study was conducted between 2004 and 2010. Claims data of oral squamous cell carcinoma patients were retrieved from the Taiwan Cancer Registry Database. Secondary data were obtained from Taiwan’s National Health Insurance Research Database.

Results: A total of 21,263 patients were included in the final analysis. The majority of the patients received treatment within 30 days of diagnosis (n = 18,193, 85.5%), while 572 patients (2.7%) underwent treatment after 120 days. The patients who were treated after 120 days had a higher risk of death when compared to those treated within 30 days (Hazard ratio: 1.32, 95% Confidence intervals: 1.19 to 1.47).

Conclusion: A longer time interval from diagnosis to treatment was found to be associated with a poorer prognosis among patients suffering from oral squamous cell carcinoma.

No MeSH data available.


Related in: MedlinePlus