Limits...
Expression of Adiponectin Receptor-1 and Prognosis of Epithelial Ovarian Cancer Patients

View Article: PubMed Central - PubMed

ABSTRACT

Background: Adiponectin receptor-1 (AdipoR1) has been reported to be associated with the risk of obesity-associated malignancies, including epithelial ovarian cancer (EOC). The aim of this study was to determine if AdipoR1 could serve as a prognosis indicator for patients with EOC.

Material/methods: In this study, expression of AdipoR1 in 73 EOC patients consecutively admitted to our hospital was detected by immunohistochemical staining. Univariate and multivariate analyses were performed to assess the relationship between AdipoR1 expression level and progression-free survival (PFS) and overall survival (OS) rates in patients.

Results: A relatively lower expression of AdipoR1 in the cancerous tissues was detected compared to normal ovarian tissues, but the difference was not significant (p>0.05). AdipoR1 expression level in EOC patients was negatively correlated with advanced FIGO stages in patients and tumor differentiation, but had no correlation with pathological types, presenting of ascites, shorter platinum-free interval (PFI), diabetes, preoperative and postoperative body mass index (BMI), or platelet counts (p>0.05). Moreover, patients with AdipoR1 expression had a significantly longer PFS and OS compared to the negative expression group (p<0.001).

Conclusions: Our findings suggest that AdipoR1 expression level in cancerous tissues might serve as an independent prognostic indicator in EOC patients and is associated with longer PFS and OS.

No MeSH data available.


Survival curves for patients with EOC according to AdipoR1 expression. The overall survival of patients with AdipoR1 positivity was significantly longer than in the negative expression group.
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC5384618&req=5

f3-medscimonit-23-1514: Survival curves for patients with EOC according to AdipoR1 expression. The overall survival of patients with AdipoR1 positivity was significantly longer than in the negative expression group.

Mentions: Our data indicated that AdipoR1 expression, FIGO stage, ascites, and diabetes were correlated with OS of EOC patients (Table 5). The median OS of AdipoR1-positive EOC patients was 60.2 months, which was significantly higher than the 23.5 months found in the AdipoR1-negative group (p<0.001). Moreover, the median OS of patients with ascites as initial manifestation was 29.7 months, which was significantly shorter than in patients without ascites (60.2 months). Furthermore, presenting of diabetes also reduced the OS from 57.7 months to 29.7 months (p=0.022). However, other clinicopathological variables, including different pathological types, tissue differentiation degree, preoperative and postoperative BMI, and platelet count, had no correlation with OS of patients with EOC in univariate analysis (p>0.05, all) (Figure 3, Table 6). Taken together, the multivariate analyses revealed that AdipoR1 expression could be an independent positive prognostic indicator of OS of EOC patients (Table 6).


Expression of Adiponectin Receptor-1 and Prognosis of Epithelial Ovarian Cancer Patients
Survival curves for patients with EOC according to AdipoR1 expression. The overall survival of patients with AdipoR1 positivity was significantly longer than in the negative expression group.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC5384618&req=5

f3-medscimonit-23-1514: Survival curves for patients with EOC according to AdipoR1 expression. The overall survival of patients with AdipoR1 positivity was significantly longer than in the negative expression group.
Mentions: Our data indicated that AdipoR1 expression, FIGO stage, ascites, and diabetes were correlated with OS of EOC patients (Table 5). The median OS of AdipoR1-positive EOC patients was 60.2 months, which was significantly higher than the 23.5 months found in the AdipoR1-negative group (p<0.001). Moreover, the median OS of patients with ascites as initial manifestation was 29.7 months, which was significantly shorter than in patients without ascites (60.2 months). Furthermore, presenting of diabetes also reduced the OS from 57.7 months to 29.7 months (p=0.022). However, other clinicopathological variables, including different pathological types, tissue differentiation degree, preoperative and postoperative BMI, and platelet count, had no correlation with OS of patients with EOC in univariate analysis (p>0.05, all) (Figure 3, Table 6). Taken together, the multivariate analyses revealed that AdipoR1 expression could be an independent positive prognostic indicator of OS of EOC patients (Table 6).

View Article: PubMed Central - PubMed

ABSTRACT

Background: Adiponectin receptor-1 (AdipoR1) has been reported to be associated with the risk of obesity-associated malignancies, including epithelial ovarian cancer (EOC). The aim of this study was to determine if AdipoR1 could serve as a prognosis indicator for patients with EOC.

Material/methods: In this study, expression of AdipoR1 in 73 EOC patients consecutively admitted to our hospital was detected by immunohistochemical staining. Univariate and multivariate analyses were performed to assess the relationship between AdipoR1 expression level and progression-free survival (PFS) and overall survival (OS) rates in patients.

Results: A relatively lower expression of AdipoR1 in the cancerous tissues was detected compared to normal ovarian tissues, but the difference was not significant (p&gt;0.05). AdipoR1 expression level in EOC patients was negatively correlated with advanced FIGO stages in patients and tumor differentiation, but had no correlation with pathological types, presenting of ascites, shorter platinum-free interval (PFI), diabetes, preoperative and postoperative body mass index (BMI), or platelet counts (p&gt;0.05). Moreover, patients with AdipoR1 expression had a significantly longer PFS and OS compared to the negative expression group (p&lt;0.001).

Conclusions: Our findings suggest that AdipoR1 expression level in cancerous tissues might serve as an independent prognostic indicator in EOC patients and is associated with longer PFS and OS.

No MeSH data available.