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Intraperitoneal Injection Is Not a Suitable Administration Route for Single-Walled Carbon Nanotubes in Biomedical Applications

View Article: PubMed Central - PubMed

ABSTRACT

Given the extensive application of carbon nanotubes (CNTs) in biomedical fields, there is increasing concern regarding unintentional health impacts. Research into safe usage is therefore increasingly necessary. This study investigated the responses of the mouse brain to single-walled CNTs (SWCNTs) delivered via intraperitoneal (IP) injection and compared these results with the previous study where SWCNTs were delivered via intravenous (IV) injection so as to explore which administration route is potentially better for SWCNTs application. This study suggests SWCNTs delivered via IP injection can have negative effects on the mouse brain through oxidative stress and inflammation at high concentration exposure, but these responses were not consistent and showed no dose-dependent effect. In a previous study, the results showed that IV-delivered SWCNTs induced a more consistent and dose-dependent effect. The comparison of the 2 studies suggested that using SWCNTs at a safe dosage delivered via IV injection may be a better administration route for SWCNTs in biomedical applications.

No MeSH data available.


Related in: MedlinePlus

Histological alterations (×40) seen in mice brains after SWCNTs exposure (Nissl staining). Each of the 6 images (1-6) correspond to 1 of the 6 different exposure groups: 0, 3. 125, 6.25, and 12.5 mg/kg/d SWCNTs; 6.25 mg/kg/d SWCNTs + 100 mg/kg/d ascorbic acid (block group); and 100 mg/kg/d ascorbic acid, respectively. SWCNTs indicates single-walled carbon nanotube.
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fig4-1559325816681320: Histological alterations (×40) seen in mice brains after SWCNTs exposure (Nissl staining). Each of the 6 images (1-6) correspond to 1 of the 6 different exposure groups: 0, 3. 125, 6.25, and 12.5 mg/kg/d SWCNTs; 6.25 mg/kg/d SWCNTs + 100 mg/kg/d ascorbic acid (block group); and 100 mg/kg/d ascorbic acid, respectively. SWCNTs indicates single-walled carbon nanotube.

Mentions: Nissl substance is a critical component in the synthesis of proteins, including many enzymes that are involved in neurotransmitter synthesis in the nerve cell, and it is very sensitive to pathological stimuli. For this reason, it is considered a good indicator of neuronal injury. Loss of Nissl substance was seen in the pyramidal cells of the hippocampus (Figure 4, Table 1).


Intraperitoneal Injection Is Not a Suitable Administration Route for Single-Walled Carbon Nanotubes in Biomedical Applications
Histological alterations (×40) seen in mice brains after SWCNTs exposure (Nissl staining). Each of the 6 images (1-6) correspond to 1 of the 6 different exposure groups: 0, 3. 125, 6.25, and 12.5 mg/kg/d SWCNTs; 6.25 mg/kg/d SWCNTs + 100 mg/kg/d ascorbic acid (block group); and 100 mg/kg/d ascorbic acid, respectively. SWCNTs indicates single-walled carbon nanotube.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License 1 - License 2 - License 3
Show All Figures
getmorefigures.php?uid=PMC5384492&req=5

fig4-1559325816681320: Histological alterations (×40) seen in mice brains after SWCNTs exposure (Nissl staining). Each of the 6 images (1-6) correspond to 1 of the 6 different exposure groups: 0, 3. 125, 6.25, and 12.5 mg/kg/d SWCNTs; 6.25 mg/kg/d SWCNTs + 100 mg/kg/d ascorbic acid (block group); and 100 mg/kg/d ascorbic acid, respectively. SWCNTs indicates single-walled carbon nanotube.
Mentions: Nissl substance is a critical component in the synthesis of proteins, including many enzymes that are involved in neurotransmitter synthesis in the nerve cell, and it is very sensitive to pathological stimuli. For this reason, it is considered a good indicator of neuronal injury. Loss of Nissl substance was seen in the pyramidal cells of the hippocampus (Figure 4, Table 1).

View Article: PubMed Central - PubMed

ABSTRACT

Given the extensive application of carbon nanotubes (CNTs) in biomedical fields, there is increasing concern regarding unintentional health impacts. Research into safe usage is therefore increasingly necessary. This study investigated the responses of the mouse brain to single-walled CNTs (SWCNTs) delivered via intraperitoneal (IP) injection and compared these results with the previous study where SWCNTs were delivered via intravenous (IV) injection so as to explore which administration route is potentially better for SWCNTs application. This study suggests SWCNTs delivered via IP injection can have negative effects on the mouse brain through oxidative stress and inflammation at high concentration exposure, but these responses were not consistent and showed no dose-dependent effect. In a previous study, the results showed that IV-delivered SWCNTs induced a more consistent and dose-dependent effect. The comparison of the 2 studies suggested that using SWCNTs at a safe dosage delivered via IV injection may be a better administration route for SWCNTs in biomedical applications.

No MeSH data available.


Related in: MedlinePlus