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Specific Roles of NMDA Receptor Subunits in Mental Disorders

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ABSTRACT

N-methyl-D-aspartate (NMDA) receptor plays important roles in learning and memory. NMDA receptors are a tetramer that consists of two glycine-binding subunits GluN1, two glutamate-binding subunits (i.e., GluN2A, GluN2B, GluN2C, and GluN2D), a combination of a GluN2 subunit and glycine-binding GluN3 subunit (i.e., GluN3A or GluN3B), or two GluN3 subunits. Recent studies revealed that the specific expression and distribution of each subunit are deeply involved in neural excitability, plasticity, and synaptic deficits. The present article summarizes reports on the dysfunction of NMDA receptors and responsible subunits in various neurological and psychiatric disorders, including schizophrenia, autoimmune-induced glutamatergic receptor dysfunction, mood disorders, and autism. A key role for the GluN2D subunit in NMDA receptor antagonist-induced psychosis has been recently revealed.

No MeSH data available.


Related in: MedlinePlus

Model of the structure of NMDA receptors. NMDA receptors are glutamate-activated ion channels in the presence of glycine expressed throughout the central nervous system. The full NMDA receptor is a tetramer, but only a GluN1/GluN2 dimer is shown. These receptors are mainly composed of two glycine (Gly)-binding GluN1 subunits and two glutamate (Glu)-binding GluN2 subunits. Each subunit is organized into four distinct domains: an extracellular N-terminal domain (ATD), a ligand-binding domain (LBD), a transmembrane pore-forming domain (TMD), and an intracellular C-terminal domain (CTD) [19].
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Figure 1: Model of the structure of NMDA receptors. NMDA receptors are glutamate-activated ion channels in the presence of glycine expressed throughout the central nervous system. The full NMDA receptor is a tetramer, but only a GluN1/GluN2 dimer is shown. These receptors are mainly composed of two glycine (Gly)-binding GluN1 subunits and two glutamate (Glu)-binding GluN2 subunits. Each subunit is organized into four distinct domains: an extracellular N-terminal domain (ATD), a ligand-binding domain (LBD), a transmembrane pore-forming domain (TMD), and an intracellular C-terminal domain (CTD) [19].


Specific Roles of NMDA Receptor Subunits in Mental Disorders
Model of the structure of NMDA receptors. NMDA receptors are glutamate-activated ion channels in the presence of glycine expressed throughout the central nervous system. The full NMDA receptor is a tetramer, but only a GluN1/GluN2 dimer is shown. These receptors are mainly composed of two glycine (Gly)-binding GluN1 subunits and two glutamate (Glu)-binding GluN2 subunits. Each subunit is organized into four distinct domains: an extracellular N-terminal domain (ATD), a ligand-binding domain (LBD), a transmembrane pore-forming domain (TMD), and an intracellular C-terminal domain (CTD) [19].
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5384360&req=5

Figure 1: Model of the structure of NMDA receptors. NMDA receptors are glutamate-activated ion channels in the presence of glycine expressed throughout the central nervous system. The full NMDA receptor is a tetramer, but only a GluN1/GluN2 dimer is shown. These receptors are mainly composed of two glycine (Gly)-binding GluN1 subunits and two glutamate (Glu)-binding GluN2 subunits. Each subunit is organized into four distinct domains: an extracellular N-terminal domain (ATD), a ligand-binding domain (LBD), a transmembrane pore-forming domain (TMD), and an intracellular C-terminal domain (CTD) [19].

View Article: PubMed Central - PubMed

ABSTRACT

N-methyl-D-aspartate (NMDA) receptor plays important roles in learning and memory. NMDA receptors are a tetramer that consists of two glycine-binding subunits GluN1, two glutamate-binding subunits (i.e., GluN2A, GluN2B, GluN2C, and GluN2D), a combination of a GluN2 subunit and glycine-binding GluN3 subunit (i.e., GluN3A or GluN3B), or two GluN3 subunits. Recent studies revealed that the specific expression and distribution of each subunit are deeply involved in neural excitability, plasticity, and synaptic deficits. The present article summarizes reports on the dysfunction of NMDA receptors and responsible subunits in various neurological and psychiatric disorders, including schizophrenia, autoimmune-induced glutamatergic receptor dysfunction, mood disorders, and autism. A key role for the GluN2D subunit in NMDA receptor antagonist-induced psychosis has been recently revealed.

No MeSH data available.


Related in: MedlinePlus