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Stem Cell Differentiation Stage Factors from Zebrafish Embryo: A Novel Strategy to Modulate the Fate of Normal and Pathological Human (Stem) Cells

View Article: PubMed Central - PubMed

ABSTRACT

In spite of the growing body of evidence on the biology of the Zebrafish embryo and stem cells, including the use of Stem Cell Differentiation Stage Factors (SCDSFs) taken from Zebrafish embryo to impact cancer cell dynamics, comparatively little is known about the possibility to use these factors to modulate the homeostasis of normal human stem cells or to modulate the behavior of cells involved in different pathological conditions. In the present review we recall in a synthetic way the most important researches about the use of SCDSFs in reprogramming cancer cells and in modulating the high speed of multiplication of keratinocytes which is characteristic of some pathological diseases like psoriasis. Moreover we add here the results about the capability of SCDSFs in modulating the homeostasis of human adipose-derived stem cells (hASCs) isolated from a fat tissue obtained with a novel-non enzymatic method and device. In addition we report the data not yet published about a first protein analysis of the SCDSFs and about their role in a pathological condition like neurodegeneration.

No MeSH data available.


The effect of the mix ABC on CA1 area cell mortality after 1 hour of serum deprivation (*p=0.005).
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Figure 1: The effect of the mix ABC on CA1 area cell mortality after 1 hour of serum deprivation (*p=0.005).

Mentions: In fact SCDSFs significantly reduce the neuronal mortality caused by serum deprivation (-31,6 ± 6,2%, p=0.005) as shown in (Fig. 1).


Stem Cell Differentiation Stage Factors from Zebrafish Embryo: A Novel Strategy to Modulate the Fate of Normal and Pathological Human (Stem) Cells
The effect of the mix ABC on CA1 area cell mortality after 1 hour of serum deprivation (*p=0.005).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5384357&req=5

Figure 1: The effect of the mix ABC on CA1 area cell mortality after 1 hour of serum deprivation (*p=0.005).
Mentions: In fact SCDSFs significantly reduce the neuronal mortality caused by serum deprivation (-31,6 ± 6,2%, p=0.005) as shown in (Fig. 1).

View Article: PubMed Central - PubMed

ABSTRACT

In spite of the growing body of evidence on the biology of the Zebrafish embryo and stem cells, including the use of Stem Cell Differentiation Stage Factors (SCDSFs) taken from Zebrafish embryo to impact cancer cell dynamics, comparatively little is known about the possibility to use these factors to modulate the homeostasis of normal human stem cells or to modulate the behavior of cells involved in different pathological conditions. In the present review we recall in a synthetic way the most important researches about the use of SCDSFs in reprogramming cancer cells and in modulating the high speed of multiplication of keratinocytes which is characteristic of some pathological diseases like psoriasis. Moreover we add here the results about the capability of SCDSFs in modulating the homeostasis of human adipose-derived stem cells (hASCs) isolated from a fat tissue obtained with a novel-non enzymatic method and device. In addition we report the data not yet published about a first protein analysis of the SCDSFs and about their role in a pathological condition like neurodegeneration.

No MeSH data available.