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The value of Nigella sativa in the treatment of experimentally induced rhinosinusitis

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ABSTRACT

The aim of this study was to investigate the effect of Nigella sativa and cephalexin in the therapy of experimental bacterial rhinosinusitis. Bacterial rhinosinusitis was induced with Staphylococcus aureus. Rabbits were divided into five groups; control (n = 6), N. sativa 50 mg/ kg/d (n = 6), N. sativa 100 mg/kg/d (n = 6), N. sativa 200 mg/kg/d (n = 6), and cephalexin 20 mg/kg/d (n = 6) groups. N. sativa was given orally for 7 days. The same volume of normal saline (0.9% NaCl) was given as a vehicle to the control group for the same period. After treatment period, sinus mucosa samples were evaluated using stereological and histopathological methods. Half of the maxillary sinus mucosa samples were frozen at -800C for further analysis of NO levels. Pathology revealed a severe acute inflammatory process in rabbits treated with saline. Only mild inflammation was determined in cephalexin group, N. sativa 100 mg/kg/d and N. sativa 200 mg/kg/d groups. The level of NO increased in the saline group was significantly reduced in all treatment groups. N. sativa may prevent histopathological changes of rhinosinusitis via decreased NO levels in a dose dependent manner and can be used in the treatment of rhinosinusitis diseases.

No MeSH data available.


Histopathological section of rabbit maxillary sinus mucosa treated with N. sativa 100 mg/kg/d (H&E X100).
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F2c: Histopathological section of rabbit maxillary sinus mucosa treated with N. sativa 100 mg/kg/d (H&E X100).

Mentions: Although the general architecture of the maxillary sinus in cephalexin groups was partly protected, no important pathological findings at the structural level were observed, but only mild inflammation (Fig. 2A). Neutrophil infiltration of the maxillary sinus was lower than in the saline group (Fig. 2A). Similar histopathological findings were observed in the N. sativa 100 mg/kg/d and N. sativa 200 mg/kg/d groups (Fig. 2C and 2D). In the N. sativa 50 mg/kg/d group, neither maxillary sinus nor vascular structures were normal in appearance compared with the cephalexin group (Fig. 2B).


The value of Nigella sativa in the treatment of experimentally induced rhinosinusitis
Histopathological section of rabbit maxillary sinus mucosa treated with N. sativa 100 mg/kg/d (H&E X100).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5384307&req=5

F2c: Histopathological section of rabbit maxillary sinus mucosa treated with N. sativa 100 mg/kg/d (H&E X100).
Mentions: Although the general architecture of the maxillary sinus in cephalexin groups was partly protected, no important pathological findings at the structural level were observed, but only mild inflammation (Fig. 2A). Neutrophil infiltration of the maxillary sinus was lower than in the saline group (Fig. 2A). Similar histopathological findings were observed in the N. sativa 100 mg/kg/d and N. sativa 200 mg/kg/d groups (Fig. 2C and 2D). In the N. sativa 50 mg/kg/d group, neither maxillary sinus nor vascular structures were normal in appearance compared with the cephalexin group (Fig. 2B).

View Article: PubMed Central - PubMed

ABSTRACT

The aim of this study was to investigate the effect of Nigella sativa and cephalexin in the therapy of experimental bacterial rhinosinusitis. Bacterial rhinosinusitis was induced with Staphylococcus aureus. Rabbits were divided into five groups; control (n = 6), N. sativa 50 mg/ kg/d (n = 6), N. sativa 100 mg/kg/d (n = 6), N. sativa 200 mg/kg/d (n = 6), and cephalexin 20 mg/kg/d (n = 6) groups. N. sativa was given orally for 7 days. The same volume of normal saline (0.9% NaCl) was given as a vehicle to the control group for the same period. After treatment period, sinus mucosa samples were evaluated using stereological and histopathological methods. Half of the maxillary sinus mucosa samples were frozen at -800C for further analysis of NO levels. Pathology revealed a severe acute inflammatory process in rabbits treated with saline. Only mild inflammation was determined in cephalexin group, N. sativa 100 mg/kg/d and N. sativa 200 mg/kg/d groups. The level of NO increased in the saline group was significantly reduced in all treatment groups. N. sativa may prevent histopathological changes of rhinosinusitis via decreased NO levels in a dose dependent manner and can be used in the treatment of rhinosinusitis diseases.

No MeSH data available.