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Overexpression of chromatin assembly factor-1/p60predicts biological behaviour of laryngeal carcinomas

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ABSTRACT

This study analysed the immunohistochemical expression of the CAF-1/p60 protein in laryngeal cancers. CAF-1/p60 assumes an independent discriminative and prognostic value in laryngeal neoplasms; the presence of this protein in carcinoma in situ compared with laryngeal precancerous and larynx infiltrating tumours. We assessed the immunohistochemical expression of CAF-1/p60 in 30 cases of moderate and/or severe dysplasia, 30 cases of carcinoma in situ and 30 cases of laryngeal squamous cell carcinoma (LSCCs). CAF-1/p60 expression increased significantly according to the high index of neoplastic cellular replication; therefore, CAF-1/p60 was overexpressed in neoplastic cells and its moderate-severe expression is correlated with poorer prognosis compared to less expression. In conclusion, overexpression of the CAF-1/p60 protein is related to a risk of higher morbidity and mortality and is a reliable independent prognostic index of laryngeal carcinoma. CAF1-p60 protein overexpression can be used in cancer management as an indicator of malignant evolution, especially in carcinoma in situ.

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Univariate analyses of overexpression, staging, grading, treatment strategy, progression and distant metastases.
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Figure 3: Univariate analyses of overexpression, staging, grading, treatment strategy, progression and distant metastases.

Mentions: Analyses of survival indicate an increased risk of recurrence and mortality concurrent with the parameters assessed by univariate analyses that assume a predictive and statistical significance in each case (Fig. 3). Multivariate analysis of these variables showed that staging, grading, treatment strategy, progress, distant metastasis are all independent prognostic factors for patients with LSCCs, and overexpression of CAF-1/p60 protein is significantly associated with poor prognosis.


Overexpression of chromatin assembly factor-1/p60predicts biological behaviour of laryngeal carcinomas
Univariate analyses of overexpression, staging, grading, treatment strategy, progression and distant metastases.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5384305&req=5

Figure 3: Univariate analyses of overexpression, staging, grading, treatment strategy, progression and distant metastases.
Mentions: Analyses of survival indicate an increased risk of recurrence and mortality concurrent with the parameters assessed by univariate analyses that assume a predictive and statistical significance in each case (Fig. 3). Multivariate analysis of these variables showed that staging, grading, treatment strategy, progress, distant metastasis are all independent prognostic factors for patients with LSCCs, and overexpression of CAF-1/p60 protein is significantly associated with poor prognosis.

View Article: PubMed Central - PubMed

ABSTRACT

This study analysed the immunohistochemical expression of the CAF-1/p60 protein in laryngeal cancers. CAF-1/p60 assumes an independent discriminative and prognostic value in laryngeal neoplasms; the presence of this protein in carcinoma in situ compared with laryngeal precancerous and larynx infiltrating tumours. We assessed the immunohistochemical expression of CAF-1/p60 in 30 cases of moderate and/or severe dysplasia, 30 cases of carcinoma in situ and 30 cases of laryngeal squamous cell carcinoma (LSCCs). CAF-1/p60 expression increased significantly according to the high index of neoplastic cellular replication; therefore, CAF-1/p60 was overexpressed in neoplastic cells and its moderate-severe expression is correlated with poorer prognosis compared to less expression. In conclusion, overexpression of the CAF-1/p60 protein is related to a risk of higher morbidity and mortality and is a reliable independent prognostic index of laryngeal carcinoma. CAF1-p60 protein overexpression can be used in cancer management as an indicator of malignant evolution, especially in carcinoma in situ.

No MeSH data available.


Related in: MedlinePlus