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Overexpression of chromatin assembly factor-1/p60predicts biological behaviour of laryngeal carcinomas

View Article: PubMed Central - PubMed

ABSTRACT

This study analysed the immunohistochemical expression of the CAF-1/p60 protein in laryngeal cancers. CAF-1/p60 assumes an independent discriminative and prognostic value in laryngeal neoplasms; the presence of this protein in carcinoma in situ compared with laryngeal precancerous and larynx infiltrating tumours. We assessed the immunohistochemical expression of CAF-1/p60 in 30 cases of moderate and/or severe dysplasia, 30 cases of carcinoma in situ and 30 cases of laryngeal squamous cell carcinoma (LSCCs). CAF-1/p60 expression increased significantly according to the high index of neoplastic cellular replication; therefore, CAF-1/p60 was overexpressed in neoplastic cells and its moderate-severe expression is correlated with poorer prognosis compared to less expression. In conclusion, overexpression of the CAF-1/p60 protein is related to a risk of higher morbidity and mortality and is a reliable independent prognostic index of laryngeal carcinoma. CAF1-p60 protein overexpression can be used in cancer management as an indicator of malignant evolution, especially in carcinoma in situ.

No MeSH data available.


Analysis of survival; A) disease-specific survival and B) overall survival.
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Figure 2: Analysis of survival; A) disease-specific survival and B) overall survival.

Mentions: Statistical analysis for non-parametric variables showed a p = 0.0015 in comparing group A, dysplasia, with group B, carcinomas in situ of the larynx (statistically significant). Comparison between group A, dysplasia, and group C, infiltrating tumours, showed a p < 0.0001 (highly statistically significant). Comparison between group B, carcinoma in situ, and group C, infiltrating tumours, revealed a p = 0.0008 (statistically significant). Analysis of the survival rate in the study population showed a statistically significant p value (p = 0.0178), which became more significant in specific disease survival (p = 0.0070) with a cumulative survival probability of 100% within 9 months of diagnosis in patients with severe expressiveness of the CAF-1/p60 protein (+++); 100% within 16 months of diagnosis in patients with moderate-severe expressiveness of CAF-1/p60 (++/+++); 100% within 32 months of diagnosis in patients with moderate expressiveness (++) of the p60 protein. No patient with mild expressiveness died of laryngeal cancer. We deduce that the probability of an adverse event (metastasis-death) is greater in cases with severe expression (score +++) of the p60 protein (Fig. 2). A Cox proportional hazards model was used to verify whether the overexpression of the p60 protein and other variables are independent prognostic factors for LSCC patients. Univariate analysis showed that overexpression, staging, grading, treatment strategy, progress and distant metastasis were associated with survival in patients with LSCC. Multivariate analysis of the same variables showed that those variables were independent prognostic factors for patients with LSCC, and overexpression of the p60 protein was significantly associated with poor prognosis.


Overexpression of chromatin assembly factor-1/p60predicts biological behaviour of laryngeal carcinomas
Analysis of survival; A) disease-specific survival and B) overall survival.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5384305&req=5

Figure 2: Analysis of survival; A) disease-specific survival and B) overall survival.
Mentions: Statistical analysis for non-parametric variables showed a p = 0.0015 in comparing group A, dysplasia, with group B, carcinomas in situ of the larynx (statistically significant). Comparison between group A, dysplasia, and group C, infiltrating tumours, showed a p < 0.0001 (highly statistically significant). Comparison between group B, carcinoma in situ, and group C, infiltrating tumours, revealed a p = 0.0008 (statistically significant). Analysis of the survival rate in the study population showed a statistically significant p value (p = 0.0178), which became more significant in specific disease survival (p = 0.0070) with a cumulative survival probability of 100% within 9 months of diagnosis in patients with severe expressiveness of the CAF-1/p60 protein (+++); 100% within 16 months of diagnosis in patients with moderate-severe expressiveness of CAF-1/p60 (++/+++); 100% within 32 months of diagnosis in patients with moderate expressiveness (++) of the p60 protein. No patient with mild expressiveness died of laryngeal cancer. We deduce that the probability of an adverse event (metastasis-death) is greater in cases with severe expression (score +++) of the p60 protein (Fig. 2). A Cox proportional hazards model was used to verify whether the overexpression of the p60 protein and other variables are independent prognostic factors for LSCC patients. Univariate analysis showed that overexpression, staging, grading, treatment strategy, progress and distant metastasis were associated with survival in patients with LSCC. Multivariate analysis of the same variables showed that those variables were independent prognostic factors for patients with LSCC, and overexpression of the p60 protein was significantly associated with poor prognosis.

View Article: PubMed Central - PubMed

ABSTRACT

This study analysed the immunohistochemical expression of the CAF-1/p60 protein in laryngeal cancers. CAF-1/p60 assumes an independent discriminative and prognostic value in laryngeal neoplasms; the presence of this protein in carcinoma in situ compared with laryngeal precancerous and larynx infiltrating tumours. We assessed the immunohistochemical expression of CAF-1/p60 in 30 cases of moderate and/or severe dysplasia, 30 cases of carcinoma in situ and 30 cases of laryngeal squamous cell carcinoma (LSCCs). CAF-1/p60 expression increased significantly according to the high index of neoplastic cellular replication; therefore, CAF-1/p60 was overexpressed in neoplastic cells and its moderate-severe expression is correlated with poorer prognosis compared to less expression. In conclusion, overexpression of the CAF-1/p60 protein is related to a risk of higher morbidity and mortality and is a reliable independent prognostic index of laryngeal carcinoma. CAF1-p60 protein overexpression can be used in cancer management as an indicator of malignant evolution, especially in carcinoma in situ.

No MeSH data available.