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Overexpression of chromatin assembly factor-1/p60predicts biological behaviour of laryngeal carcinomas

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ABSTRACT

This study analysed the immunohistochemical expression of the CAF-1/p60 protein in laryngeal cancers. CAF-1/p60 assumes an independent discriminative and prognostic value in laryngeal neoplasms; the presence of this protein in carcinoma in situ compared with laryngeal precancerous and larynx infiltrating tumours. We assessed the immunohistochemical expression of CAF-1/p60 in 30 cases of moderate and/or severe dysplasia, 30 cases of carcinoma in situ and 30 cases of laryngeal squamous cell carcinoma (LSCCs). CAF-1/p60 expression increased significantly according to the high index of neoplastic cellular replication; therefore, CAF-1/p60 was overexpressed in neoplastic cells and its moderate-severe expression is correlated with poorer prognosis compared to less expression. In conclusion, overexpression of the CAF-1/p60 protein is related to a risk of higher morbidity and mortality and is a reliable independent prognostic index of laryngeal carcinoma. CAF1-p60 protein overexpression can be used in cancer management as an indicator of malignant evolution, especially in carcinoma in situ.

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A) Laryngeal mucosa with moderat-severe dysplasia and with mild (+) expression of CAF-1/p60; B) Laryngeal mucosa with cancer in situ and with severe (+++) expression of CAF-1/ p60; C- D) High expression (+++) of CAF-1/ p60 in moderately differentiated cancer (G2) and in undifferentiated cancer (G3).
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Figure 1: A) Laryngeal mucosa with moderat-severe dysplasia and with mild (+) expression of CAF-1/p60; B) Laryngeal mucosa with cancer in situ and with severe (+++) expression of CAF-1/ p60; C- D) High expression (+++) of CAF-1/ p60 in moderately differentiated cancer (G2) and in undifferentiated cancer (G3).

Mentions: Patients with moderate and/or severe dysplasia showed a mild (+) expression of CAF-1/p60 in all cases evaluated (100%) (Fig. 1).


Overexpression of chromatin assembly factor-1/p60predicts biological behaviour of laryngeal carcinomas
A) Laryngeal mucosa with moderat-severe dysplasia and with mild (+) expression of CAF-1/p60; B) Laryngeal mucosa with cancer in situ and with severe (+++) expression of CAF-1/ p60; C- D) High expression (+++) of CAF-1/ p60 in moderately differentiated cancer (G2) and in undifferentiated cancer (G3).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
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getmorefigures.php?uid=PMC5384305&req=5

Figure 1: A) Laryngeal mucosa with moderat-severe dysplasia and with mild (+) expression of CAF-1/p60; B) Laryngeal mucosa with cancer in situ and with severe (+++) expression of CAF-1/ p60; C- D) High expression (+++) of CAF-1/ p60 in moderately differentiated cancer (G2) and in undifferentiated cancer (G3).
Mentions: Patients with moderate and/or severe dysplasia showed a mild (+) expression of CAF-1/p60 in all cases evaluated (100%) (Fig. 1).

View Article: PubMed Central - PubMed

ABSTRACT

This study analysed the immunohistochemical expression of the CAF-1/p60 protein in laryngeal cancers. CAF-1/p60 assumes an independent discriminative and prognostic value in laryngeal neoplasms; the presence of this protein in carcinoma in situ compared with laryngeal precancerous and larynx infiltrating tumours. We assessed the immunohistochemical expression of CAF-1/p60 in 30 cases of moderate and/or severe dysplasia, 30 cases of carcinoma in situ and 30 cases of laryngeal squamous cell carcinoma (LSCCs). CAF-1/p60 expression increased significantly according to the high index of neoplastic cellular replication; therefore, CAF-1/p60 was overexpressed in neoplastic cells and its moderate-severe expression is correlated with poorer prognosis compared to less expression. In conclusion, overexpression of the CAF-1/p60 protein is related to a risk of higher morbidity and mortality and is a reliable independent prognostic index of laryngeal carcinoma. CAF1-p60 protein overexpression can be used in cancer management as an indicator of malignant evolution, especially in carcinoma in situ.

No MeSH data available.


Related in: MedlinePlus