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Novel miRNA-mRNA interactions conserved in essential cancer pathways

View Article: PubMed Central - PubMed

ABSTRACT

Cancer is a complex disease in which unrestrained cell proliferation results in tumour development. Extensive research into the molecular mechanisms underlying tumorigenesis has led to the characterization of oncogenes and tumour suppressors that are key elements in cancer growth and progression, as well as that of other important elements like microRNAs. These genes and miRNAs appear to be constitutively deregulated in cancer. To identify signatures of miRNA-mRNA interactions potentially conserved in essential cancer pathways, we have conducted an integrative analysis of transcriptomic data, also taking into account methylation and copy number alterations. We analysed 18,605 raw transcriptome samples from The Cancer Genome Atlas covering 15 of the most common types of human tumours. From this global transcriptome study, we recovered known cancer-associated miRNA-targets and importantly, we identified new potential targets from miRNA families, also analysing the phenotypic outcomes of these genes/mRNAs in terms of survival. Further analyses could lead to novel approaches in cancer therapy.

No MeSH data available.


Related in: MedlinePlus

Number of differentially expressed genes and miRNAs (over-expressed and repressed) in each tumour type.
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f1: Number of differentially expressed genes and miRNAs (over-expressed and repressed) in each tumour type.

Mentions: We performed a comprehensive statistical analysis on a set of 15 tumours to identify novel miRNA-mRNA associations that might commonly be deregulated. To this end, we extracted data on differentially expressed genes and miRNAs, comparing samples from healthy subjects and tumour patients from each tumour (see Fig. 1 for the number of significantly deregulated genes and miRNAs).


Novel miRNA-mRNA interactions conserved in essential cancer pathways
Number of differentially expressed genes and miRNAs (over-expressed and repressed) in each tumour type.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5384238&req=5

f1: Number of differentially expressed genes and miRNAs (over-expressed and repressed) in each tumour type.
Mentions: We performed a comprehensive statistical analysis on a set of 15 tumours to identify novel miRNA-mRNA associations that might commonly be deregulated. To this end, we extracted data on differentially expressed genes and miRNAs, comparing samples from healthy subjects and tumour patients from each tumour (see Fig. 1 for the number of significantly deregulated genes and miRNAs).

View Article: PubMed Central - PubMed

ABSTRACT

Cancer is a complex disease in which unrestrained cell proliferation results in tumour development. Extensive research into the molecular mechanisms underlying tumorigenesis has led to the characterization of oncogenes and tumour suppressors that are key elements in cancer growth and progression, as well as that of other important elements like microRNAs. These genes and miRNAs appear to be constitutively deregulated in cancer. To identify signatures of miRNA-mRNA interactions potentially conserved in essential cancer pathways, we have conducted an integrative analysis of transcriptomic data, also taking into account methylation and copy number alterations. We analysed 18,605 raw transcriptome samples from The Cancer Genome Atlas covering 15 of the most common types of human tumours. From this global transcriptome study, we recovered known cancer-associated miRNA-targets and importantly, we identified new potential targets from miRNA families, also analysing the phenotypic outcomes of these genes/mRNAs in terms of survival. Further analyses could lead to novel approaches in cancer therapy.

No MeSH data available.


Related in: MedlinePlus