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Contrast Sensitivity in Microtropic and Anisometropic Eyes of Successfully Treated Amblyopes

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ABSTRACT

Objectives:: To assess and compare contrast sensitivity function in the previously amblyopic and non-amblyopic “normal” eyes of patients with microtropia and anisometropia who achieved 20/20 visual acuity after occlusion therapy.

Materials and methods:: Contrast sensitivity was tested monocularly on both eyes of 34 successfully treated microtropic and 15 anisometropic subjects (visual acuity 20/20 in both eyes). Contrast sensitivity function was evaluated by CSV-1000E and age-matched nomograms were used (spatial frequencies of 3, 6, 12, and 18 cycles per degree [cpd]) for comparison.

Results:: The mean age of subjects was 11.2±1.3 years in the microtropic group, 9.8±1.7 years in the anisometropic group (7-12 years); the mean follow-up time was 16.4±3.2 months (12 to 92) in the microtropic group and 27.7±1.8 months (12-84) in the anisometropic group. Statistical comparison of the microtropic amblyopic eyes versus non-microtropic eyes showed significant differences at spatial frequencies of 3, 12 and 18 cpd (3 cpd, t=2.8, p=0.007; 6 cpd, t=1.1 p=0.261; 12 cpd, t=2.2, p=0.033; 18 cpd, t=2.2, p=0.030). When anisometropic eyes were compared with non-anisometropic eyes, there was a significant difference only at 12 cpd (t=2.1 p=0.049). The comparison of non-amblyopic eyes versus age-matched nomograms revealed no differences at any of the spatial frequencies (p>0.05 for all).

Conclusion:: Contrast sensitivity was decreased in patients with amblyopia, especially in the microtropic group. The assessment of contrast sensitivity function may serve as a new parameter for termination of occlusion therapy.

No MeSH data available.


Mean contrast sensitivity function values of the microtropic eyes (dotted line) and non-microtropic eyes (solid line)
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f2: Mean contrast sensitivity function values of the microtropic eyes (dotted line) and non-microtropic eyes (solid line)

Mentions: Paired-samples test of microtropic eyes and non-microtropic eyes showed significant differences at spatial frequencies of 3, 12, and 18 cpd (3 cpd: t=2.8, p=0.007; 12 cpd: t=2.2, p=0.033; 18 cpd: t=2.2, p=0.030) (Figure 2, Figure 3A, 3B, 3C, 3D), but there was no significant difference at 6 cpd (6 cpd, t=1.1 p=0.261). In paired t-test of the anisometropic and non-anisometropic eyes, a slight reduction was observed at 12 cpd, while no significant differences emerged in 3, 6, or 18 cpd (3 cpd, t=1.8 p=0.089; 6 cpd, t=1.3 p=0.207; 18 cpd, t=1.2 p=0.219) (Figure 4, Figure 5A, 5B, 5C, 5D). Comparison of non-microtropic and non-anisometropic eyes with age-matched nomograms revealed no significant differences at any of the spatial frequencies (non-microtropic eyes: 3 cpd, p=0.075; 6 cpd, p=0.670; 12 cpd, p=0.846; 18 cpd, p=0.121; non-anisometropic eyes: 3 cpd, p=0.454; 6 cpd, p=0.116; 12 cpd, p=0.309; 18 cpd, p=0.196).


Contrast Sensitivity in Microtropic and Anisometropic Eyes of Successfully Treated Amblyopes
Mean contrast sensitivity function values of the microtropic eyes (dotted line) and non-microtropic eyes (solid line)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5384123&req=5

f2: Mean contrast sensitivity function values of the microtropic eyes (dotted line) and non-microtropic eyes (solid line)
Mentions: Paired-samples test of microtropic eyes and non-microtropic eyes showed significant differences at spatial frequencies of 3, 12, and 18 cpd (3 cpd: t=2.8, p=0.007; 12 cpd: t=2.2, p=0.033; 18 cpd: t=2.2, p=0.030) (Figure 2, Figure 3A, 3B, 3C, 3D), but there was no significant difference at 6 cpd (6 cpd, t=1.1 p=0.261). In paired t-test of the anisometropic and non-anisometropic eyes, a slight reduction was observed at 12 cpd, while no significant differences emerged in 3, 6, or 18 cpd (3 cpd, t=1.8 p=0.089; 6 cpd, t=1.3 p=0.207; 18 cpd, t=1.2 p=0.219) (Figure 4, Figure 5A, 5B, 5C, 5D). Comparison of non-microtropic and non-anisometropic eyes with age-matched nomograms revealed no significant differences at any of the spatial frequencies (non-microtropic eyes: 3 cpd, p=0.075; 6 cpd, p=0.670; 12 cpd, p=0.846; 18 cpd, p=0.121; non-anisometropic eyes: 3 cpd, p=0.454; 6 cpd, p=0.116; 12 cpd, p=0.309; 18 cpd, p=0.196).

View Article: PubMed Central - PubMed

ABSTRACT

Objectives:: To assess and compare contrast sensitivity function in the previously amblyopic and non-amblyopic “normal” eyes of patients with microtropia and anisometropia who achieved 20/20 visual acuity after occlusion therapy.

Materials and methods:: Contrast sensitivity was tested monocularly on both eyes of 34 successfully treated microtropic and 15 anisometropic subjects (visual acuity 20/20 in both eyes). Contrast sensitivity function was evaluated by CSV-1000E and age-matched nomograms were used (spatial frequencies of 3, 6, 12, and 18 cycles per degree [cpd]) for comparison.

Results:: The mean age of subjects was 11.2±1.3 years in the microtropic group, 9.8±1.7 years in the anisometropic group (7-12 years); the mean follow-up time was 16.4±3.2 months (12 to 92) in the microtropic group and 27.7±1.8 months (12-84) in the anisometropic group. Statistical comparison of the microtropic amblyopic eyes versus non-microtropic eyes showed significant differences at spatial frequencies of 3, 12 and 18 cpd (3 cpd, t=2.8, p=0.007; 6 cpd, t=1.1 p=0.261; 12 cpd, t=2.2, p=0.033; 18 cpd, t=2.2, p=0.030). When anisometropic eyes were compared with non-anisometropic eyes, there was a significant difference only at 12 cpd (t=2.1 p=0.049). The comparison of non-amblyopic eyes versus age-matched nomograms revealed no differences at any of the spatial frequencies (p>0.05 for all).

Conclusion:: Contrast sensitivity was decreased in patients with amblyopia, especially in the microtropic group. The assessment of contrast sensitivity function may serve as a new parameter for termination of occlusion therapy.

No MeSH data available.