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IL-6, Antioxidant Capacity and Muscle Damage Markers Following High-Intensity Interval Training Protocols

View Article: PubMed Central - PubMed

ABSTRACT

The aim of this study was to investigate changes of interleukin-6 (IL-6), total antioxidant capacity (TAC) and muscle damage markers (creatine kinase (CK), myoglobin and lactate dehydrogenase (LDH)) in response to three different high-intensity interval training (HIIT) protocols of identical external work. Twelve moderately-trained males participated in the three HIIT trials which consisted of a warm-up, followed by 12 min of 15 s, 30 s or 60 s HIIT sequences with the work/rest ratio 1. The biochemical markers of inflammation, oxidative stress and muscle damage were analysed POST, 3 h and 24 h after the exercise. All HIIT protocols caused an immediate increase in IL-6, TAC, CK, myoglobin and LDH. The most pronounced between-trials differences were found for the POST-exercise changes in IL-6 (Effect size ± 90% confidence interval: 1.51 ± 0.63, 0.84 ± 0.34 and 1.80 ± 0.60 for the 15s/15s, 30s/30s and 60s/60s protocol, respectively) and myoglobin (1.11 ± 0.29, 0.45 ± 0.48 and 1.09 ± 0.22 for the 15s/15s, 30s/30s and 60s/60s protocol, respectively). There were no substantial between-trial differences in other biochemical variables. In conclusion, the 15s/15s and 60s/60s protocols might be preferred to the 30s/30s protocols in order to maximize the training stimulus.

No MeSH data available.


Standardized differences in Interleukin-6 and Total antioxidant capacity post-exercise changes with 90% confidence intervals for the 15/15, 30/30, 60/60 HIIT trials.The grey shaded area indicates the smallest worthwhile change.
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j_hukin-2017-0031_fig_001: Standardized differences in Interleukin-6 and Total antioxidant capacity post-exercise changes with 90% confidence intervals for the 15/15, 30/30, 60/60 HIIT trials.The grey shaded area indicates the smallest worthwhile change.

Mentions: All HIIT trials increased the POSTexercise IL-6 concentration. IL-6 most likely largely increased after the 15/15 (ES ± 90% CI: 1.51 ± 0.63) and 60/60 protocol (1.80 ± 0.60), whereas the IL-6 increase after the 30/30 protocol was most likely moderate (0.84 ± 0.34). Considering 3 h and 24 h measuring time points following all HIIT trials, IL-6 substantially decreased with at most moderate differences from the PRE-exercise level (Table 1, Figure 1).


IL-6, Antioxidant Capacity and Muscle Damage Markers Following High-Intensity Interval Training Protocols
Standardized differences in Interleukin-6 and Total antioxidant capacity post-exercise changes with 90% confidence intervals for the 15/15, 30/30, 60/60 HIIT trials.The grey shaded area indicates the smallest worthwhile change.
© Copyright Policy
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC5384061&req=5

j_hukin-2017-0031_fig_001: Standardized differences in Interleukin-6 and Total antioxidant capacity post-exercise changes with 90% confidence intervals for the 15/15, 30/30, 60/60 HIIT trials.The grey shaded area indicates the smallest worthwhile change.
Mentions: All HIIT trials increased the POSTexercise IL-6 concentration. IL-6 most likely largely increased after the 15/15 (ES ± 90% CI: 1.51 ± 0.63) and 60/60 protocol (1.80 ± 0.60), whereas the IL-6 increase after the 30/30 protocol was most likely moderate (0.84 ± 0.34). Considering 3 h and 24 h measuring time points following all HIIT trials, IL-6 substantially decreased with at most moderate differences from the PRE-exercise level (Table 1, Figure 1).

View Article: PubMed Central - PubMed

ABSTRACT

The aim of this study was to investigate changes of interleukin-6 (IL-6), total antioxidant capacity (TAC) and muscle damage markers (creatine kinase (CK), myoglobin and lactate dehydrogenase (LDH)) in response to three different high-intensity interval training (HIIT) protocols of identical external work. Twelve moderately-trained males participated in the three HIIT trials which consisted of a warm-up, followed by 12 min of 15 s, 30 s or 60 s HIIT sequences with the work/rest ratio 1. The biochemical markers of inflammation, oxidative stress and muscle damage were analysed POST, 3 h and 24 h after the exercise. All HIIT protocols caused an immediate increase in IL-6, TAC, CK, myoglobin and LDH. The most pronounced between-trials differences were found for the POST-exercise changes in IL-6 (Effect size ± 90% confidence interval: 1.51 ± 0.63, 0.84 ± 0.34 and 1.80 ± 0.60 for the 15s/15s, 30s/30s and 60s/60s protocol, respectively) and myoglobin (1.11 ± 0.29, 0.45 ± 0.48 and 1.09 ± 0.22 for the 15s/15s, 30s/30s and 60s/60s protocol, respectively). There were no substantial between-trial differences in other biochemical variables. In conclusion, the 15s/15s and 60s/60s protocols might be preferred to the 30s/30s protocols in order to maximize the training stimulus.

No MeSH data available.