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Genetic polymorphisms in ERCC1 and ERCC2 genes are associated with response to chemotherapy in osteosarcoma patients among Chinese population: a meta-analysis

View Article: PubMed Central - PubMed

ABSTRACT

Background: There existed controversies about the association between the response to chemotherapy for osteosarcoma (OS) patients and the genetic polymorphisms in excision repair cross-complementation group (ERCC1 and ERCC2) genes. We aimed to perform a meta-analysis to comprehensively evaluate the association.

Method: We searched multiple databases for literature retrieval including the PubMED (1966 ∼ 2017), Embase (1980 ∼ 2017), and the Web of science (1945 ∼ 2017). The overall odds ratios(OR) and their corresponding 95% confidence interval (CI) were calculated for the three polymorphisms under the dominant, recessive, and allelic models.

Results: From six eligible articles in our study, we found that for ERCC1 rs11615 polymorphism, a significant association was detected between the chemotherapy response and the polymorphism under all three models (dominant model: OR = 2.015, P = 0.005; recessive model: OR = 1.791, P = 0.003; allelic model: OR = 1.677, P = 0.003), and OS patients carrying C allele in rs11615 polymorphism were more likely to response to chemotherapy. In terms of ERCC2 rs1799793 polymorphism, this polymorphism was significantly associated with the response to chemotherapy for OS patients under recessive model (OR = 1.337, P = 0.036), and patients with AG + AA genotype in rs1799793 polymorphism were more appropriate to receive chemotherapy. With respect to ERCC2 rs13181 polymorphism, this polymorphism was not correlated with the response to chemotherapy for OS patients under all three models.

Conclusions: Our meta-analysis suggested that among Chinese population, the rs11615 and rs1799793 polymorphisms were significantly correlated with the response to chemotherapy for patients with OS, and patients with CC or TC + CC genotypes in ERCC1 rs11615 polymorphism or AG + AA genotype in ERCC2 rs1799793 polymorphism were more suitable for chemotherapy.

No MeSH data available.


Forest plot of study evaluating the relationship between the response to chemotherapy for OS patients and the ERCC1 rs11615 polymorphism
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Fig2: Forest plot of study evaluating the relationship between the response to chemotherapy for OS patients and the ERCC1 rs11615 polymorphism

Mentions: Five studies including 1019 OS patients were incorporated to evaluate the association of the rs11615 polymorphism and the response to chemotherapy. The results could be found in Table 2. For dominant (TT + TC versus CC) and allelic models (T versus C), the random effects model was chosen to calculate the OR and 95% CI due to the large heterogeneity. The ORs for TT + TC versus CC and T versus C were 2.015 and 1.677, respectively (TT + TC versus CC: 95% CI:1.242–3.271, P = 0.005, Fig. 2; T versus C: 95% CI: 1.194–2.356, P = 0.003, Fig. 2), which suggested that significant association was detected between the rs11615 polymorphism and the response to chemotherapy for OS patients under the dominant and allelic models, and there were more responders to chemotherapy in patients with CC genotype in rs11615 polymorphism. With regard to the recessive model (TT versus CC + TC), considering the small heterogeneity, we selected the fixed-effects model to yield the OR for this model. The OR for TT versus CC + TC was 1.791 (95% CI:1.353–2.372, P = 0.003, Fig. 2), revealing that the rs11615 polymorphism was significantly associated with the response to chemotherapy for OS patients under recessive model, and patients with CC + TC genotype in rs11615 polymorphism had higher response rate to chemotherapy.Table 2


Genetic polymorphisms in ERCC1 and ERCC2 genes are associated with response to chemotherapy in osteosarcoma patients among Chinese population: a meta-analysis
Forest plot of study evaluating the relationship between the response to chemotherapy for OS patients and the ERCC1 rs11615 polymorphism
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC5383995&req=5

Fig2: Forest plot of study evaluating the relationship between the response to chemotherapy for OS patients and the ERCC1 rs11615 polymorphism
Mentions: Five studies including 1019 OS patients were incorporated to evaluate the association of the rs11615 polymorphism and the response to chemotherapy. The results could be found in Table 2. For dominant (TT + TC versus CC) and allelic models (T versus C), the random effects model was chosen to calculate the OR and 95% CI due to the large heterogeneity. The ORs for TT + TC versus CC and T versus C were 2.015 and 1.677, respectively (TT + TC versus CC: 95% CI:1.242–3.271, P = 0.005, Fig. 2; T versus C: 95% CI: 1.194–2.356, P = 0.003, Fig. 2), which suggested that significant association was detected between the rs11615 polymorphism and the response to chemotherapy for OS patients under the dominant and allelic models, and there were more responders to chemotherapy in patients with CC genotype in rs11615 polymorphism. With regard to the recessive model (TT versus CC + TC), considering the small heterogeneity, we selected the fixed-effects model to yield the OR for this model. The OR for TT versus CC + TC was 1.791 (95% CI:1.353–2.372, P = 0.003, Fig. 2), revealing that the rs11615 polymorphism was significantly associated with the response to chemotherapy for OS patients under recessive model, and patients with CC + TC genotype in rs11615 polymorphism had higher response rate to chemotherapy.Table 2

View Article: PubMed Central - PubMed

ABSTRACT

Background: There existed controversies about the association between the response to chemotherapy for osteosarcoma (OS) patients and the genetic polymorphisms in excision repair cross-complementation group (ERCC1 and ERCC2) genes. We aimed to perform a meta-analysis to comprehensively evaluate the association.

Method: We searched multiple databases for literature retrieval including the PubMED (1966 ∼ 2017), Embase (1980 ∼ 2017), and the Web of science (1945 ∼ 2017). The overall odds ratios(OR) and their corresponding 95% confidence interval (CI) were calculated for the three polymorphisms under the dominant, recessive, and allelic models.

Results: From six eligible articles in our study, we found that for ERCC1 rs11615 polymorphism, a significant association was detected between the chemotherapy response and the polymorphism under all three models (dominant model: OR = 2.015, P = 0.005; recessive model: OR = 1.791, P = 0.003; allelic model: OR = 1.677, P = 0.003), and OS patients carrying C allele in rs11615 polymorphism were more likely to response to chemotherapy. In terms of ERCC2 rs1799793 polymorphism, this polymorphism was significantly associated with the response to chemotherapy for OS patients under recessive model (OR = 1.337, P = 0.036), and patients with AG + AA genotype in rs1799793 polymorphism were more appropriate to receive chemotherapy. With respect to ERCC2 rs13181 polymorphism, this polymorphism was not correlated with the response to chemotherapy for OS patients under all three models.

Conclusions: Our meta-analysis suggested that among Chinese population, the rs11615 and rs1799793 polymorphisms were significantly correlated with the response to chemotherapy for patients with OS, and patients with CC or TC + CC genotypes in ERCC1 rs11615 polymorphism or AG + AA genotype in ERCC2 rs1799793 polymorphism were more suitable for chemotherapy.

No MeSH data available.