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Renal function had an independent relationship with coronary artery calcification in Chinese elderly men

View Article: PubMed Central - PubMed

ABSTRACT

Background: Although previous studies have analyzed the relationship between renal function and coronary artery calcification (CAC) in pre-dialysis and dialysis patients, limited studies have discussed the relationship between renal function and CAC in Chinese elderly men without obvious damage of renal function. The present study was designed to explore the relationship between renal function and CAC in Chinese elderly men without obvious damage of renal function.

Methods: This cross-sectional study was carried out in 105 male participants older than 60 years with glomerular filtration rate (GFR) ≥ 45 ml/min/1.73 m2. CAC was detected by high-definition computerized tomography (HDCT), which is a highly sensitive technique for detecting the CAC and provides the most accurate CAC scores up to date.

Results: Age was 72 ± 8.4 years on average and ranged from 60 to 89 years. Simple correlation analysis indicated that all kinds of CAC scores including the Agatston, volume and mass scores inversely correlated with GFR values (p < 0.05 for all). In multivariate linear regression analysis, GFR values were independently associated with all these CAC scores (p < 0.05 for all).

Conclusion: Renal function had an independent relationship with CAC detected by HDCT in Chinese elderly men, demonstrating that the relationship between renal function and CAC started at the early stage of renal function decline.

No MeSH data available.


Flow chart of study participants with inclusion and exclusion criteria
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Fig1: Flow chart of study participants with inclusion and exclusion criteria

Mentions: Participants underwent the scans of HDCT (Discovery CT 750 HD, GE Healthcare, Wisconsin, USA). All scans were performed in the same room using the same equipment, and analyzed by the consensus of two radiologists with more than two years of experience blinded to all participants and prior information. For defining the quantity of coronary calcium, the Agatston, volume and mass scores were calculated using the software (Smart Score 4.0, GE Healthcare, Wisconsin, USA) on the three-dimensional workstation (Advantage Windows Workstation 4.5, GE Healthcare, Wisconsin, USA), according to the following equations: 1) Agatston score = slice increment/slice thickness × ∑(area × cofactor); 2) volume score = ∑(area × slice increment); and 3) mass score = ∑(area × slice increment × mean CT density) × calibration factor [13, 14]. The sum of all scores for each coronary artery including left main artery, left anterior descending artery, left circumflex artery and right coronary artery was used to generate the total CAC scores (Fig. 1).Fig. 1


Renal function had an independent relationship with coronary artery calcification in Chinese elderly men
Flow chart of study participants with inclusion and exclusion criteria
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC5383987&req=5

Fig1: Flow chart of study participants with inclusion and exclusion criteria
Mentions: Participants underwent the scans of HDCT (Discovery CT 750 HD, GE Healthcare, Wisconsin, USA). All scans were performed in the same room using the same equipment, and analyzed by the consensus of two radiologists with more than two years of experience blinded to all participants and prior information. For defining the quantity of coronary calcium, the Agatston, volume and mass scores were calculated using the software (Smart Score 4.0, GE Healthcare, Wisconsin, USA) on the three-dimensional workstation (Advantage Windows Workstation 4.5, GE Healthcare, Wisconsin, USA), according to the following equations: 1) Agatston score = slice increment/slice thickness × ∑(area × cofactor); 2) volume score = ∑(area × slice increment); and 3) mass score = ∑(area × slice increment × mean CT density) × calibration factor [13, 14]. The sum of all scores for each coronary artery including left main artery, left anterior descending artery, left circumflex artery and right coronary artery was used to generate the total CAC scores (Fig. 1).Fig. 1

View Article: PubMed Central - PubMed

ABSTRACT

Background: Although previous studies have analyzed the relationship between renal function and coronary artery calcification (CAC) in pre-dialysis and dialysis patients, limited studies have discussed the relationship between renal function and CAC in Chinese elderly men without obvious damage of renal function. The present study was designed to explore the relationship between renal function and CAC in Chinese elderly men without obvious damage of renal function.

Methods: This cross-sectional study was carried out in 105 male participants older than 60 years with glomerular filtration rate (GFR) ≥ 45 ml/min/1.73 m2. CAC was detected by high-definition computerized tomography (HDCT), which is a highly sensitive technique for detecting the CAC and provides the most accurate CAC scores up to date.

Results: Age was 72 ± 8.4 years on average and ranged from 60 to 89 years. Simple correlation analysis indicated that all kinds of CAC scores including the Agatston, volume and mass scores inversely correlated with GFR values (p < 0.05 for all). In multivariate linear regression analysis, GFR values were independently associated with all these CAC scores (p < 0.05 for all).

Conclusion: Renal function had an independent relationship with CAC detected by HDCT in Chinese elderly men, demonstrating that the relationship between renal function and CAC started at the early stage of renal function decline.

No MeSH data available.