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Treatment with penicillin G and hydrocortisone reduces ALS-associated symptoms: a case series of three patients

View Article: PubMed Central - PubMed

ABSTRACT

Three male Caucasian patients with ALS were admitted to the hospital due to progressive dysphagia and dysarthria.

During two 21-day courses of penicillin G and hydrocortisone, these patients’ dysphagia and dysarthria resolved. The patient’s other ALS-associated symptoms also improved, including respiratory function, coordination, walking, and muscle strength.

This is the first report of a treatment with a protocol for treating dysphagia, dysarthria, respiratory depression and other ALS-related symptoms. Furthermore, the observations are consistent with the recent hypothesis that the successful treatment of ALS symptoms with this treatment course in six patients with syphilitic ALS was not directly due to the treatment of syphilis; but that the administered penicillin G and/or hydrocortisone treated these patients’ ALS symptoms due the off-target pharmacological activity of penicillin G and/or hydrocortisone. This report therefore underscores the need to evaluate the efficacy of this treatment course in a clinical trial.

No MeSH data available.


Related in: MedlinePlus

The clinical progression and effect of treatment in Patient 2.
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f3: The clinical progression and effect of treatment in Patient 2.

Mentions: In the year preceding admission to the hospital, the patient’s speech had degenerated, and the patient had difficulty swallowing both solid food and liquids, including saliva, leading to the manifestation of a high frequency of coughing.Figure 3 shows the progression of symptoms and the effect of treatment in Patient 2. Dysphagia was confirmed by FEES examination at the time of admission (Movie 6), and speech impairment was confirmed by a speech therapist. Physical examination and laboratory blood analysis revealed no other clinical pathology and normal renal function; a test for syphilis was negative. The only prescription medication taken by the patient was Riluzole (100 mg/day).


Treatment with penicillin G and hydrocortisone reduces ALS-associated symptoms: a case series of three patients
The clinical progression and effect of treatment in Patient 2.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5383939&req=5

f3: The clinical progression and effect of treatment in Patient 2.
Mentions: In the year preceding admission to the hospital, the patient’s speech had degenerated, and the patient had difficulty swallowing both solid food and liquids, including saliva, leading to the manifestation of a high frequency of coughing.Figure 3 shows the progression of symptoms and the effect of treatment in Patient 2. Dysphagia was confirmed by FEES examination at the time of admission (Movie 6), and speech impairment was confirmed by a speech therapist. Physical examination and laboratory blood analysis revealed no other clinical pathology and normal renal function; a test for syphilis was negative. The only prescription medication taken by the patient was Riluzole (100 mg/day).

View Article: PubMed Central - PubMed

ABSTRACT

Three male Caucasian patients with ALS were admitted to the hospital due to progressive dysphagia and dysarthria.

During two 21-day courses of penicillin G and hydrocortisone, these patients’ dysphagia and dysarthria resolved. The patient’s other ALS-associated symptoms also improved, including respiratory function, coordination, walking, and muscle strength.

This is the first report of a treatment with a protocol for treating dysphagia, dysarthria, respiratory depression and other ALS-related symptoms. Furthermore, the observations are consistent with the recent hypothesis that the successful treatment of ALS symptoms with this treatment course in six patients with syphilitic ALS was not directly due to the treatment of syphilis; but that the administered penicillin G and/or hydrocortisone treated these patients’ ALS symptoms due the off-target pharmacological activity of penicillin G and/or hydrocortisone. This report therefore underscores the need to evaluate the efficacy of this treatment course in a clinical trial.

No MeSH data available.


Related in: MedlinePlus