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The Effect of Micro-Spicule Containing Epidermal Growth Factor on Periocular Wrinkles

View Article: PubMed Central - PubMed

ABSTRACT

Background: Micro-needle patches have been recently used to increase skin permeability, which improves drug delivery, and for cosmetic purposes. However, these patches may often have limited efficacy due to insufficient skin penetration and reduced compliance caused by discomfort.

Objective: We evaluated the efficacy and the safety of soluble micro-spicule containing epidermal growth factor (MS-EGF) for the treatment of periocular wrinkles.

Methods: Twenty healthy volunteers aged 33 to 54 years were enrolled in a randomized, controlled, split-face study. For 4 weeks, a periocular wrinkle was treated daily with either a soluble MS-EGF cream or a cream containing EGF alone. All subjects underwent 8 weeks of follow-up. Efficacy was assessed using an ultrasonic measurement of dermal depth and density, digital skin image analysis, 5-point photonumeric scale for periocular wrinkles and subjective satisfaction.

Results: MS-EGF group showed statistically significant increase of dermal depth and density compared to EGF alone group after 4 and 8 weeks. In addition, there was a marked improvement shown in clinical and 3-dimensional skin image in MS-EGF group. The treatments were well-tolerated; no significant side-effect was noted.

Conclusion: The MS-EGF formulation may represent an effective and biocompatible advance in the treatment of periocular wrinkles.

No MeSH data available.


Subjective evaluation of the treatment results on micro-spicule containing epidermal growth factor (MS-EGF) and epidermal growth factor (EGF) alone group. VS: very satisfied, S: satisfied, SS: slightly satisfied, DS: dissatisfied.
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Figure 4: Subjective evaluation of the treatment results on micro-spicule containing epidermal growth factor (MS-EGF) and epidermal growth factor (EGF) alone group. VS: very satisfied, S: satisfied, SS: slightly satisfied, DS: dissatisfied.

Mentions: Subjective improvement was also assessed by all participants upon completing the study. Among the participants who received MS-EGF treatment, 70% were “very satisfied” or “satisfied” after the treatment, whereas only 15% were “dissatisfied.” For the EGF alone group, 50% were “very satisfied” or “satisfied” after treatment whereas 20% were “dissatisfied” (Fig. 4). The treatments were well-tolerated by most patients and there were no noticeable adverse events such as inflammation, desquamation and pigmentation in either of the treated areas. Six participants in MS-EGF experienced transient erythema and a prickling sensation immediately after the application, which resolved within a few minutes without special management.


The Effect of Micro-Spicule Containing Epidermal Growth Factor on Periocular Wrinkles
Subjective evaluation of the treatment results on micro-spicule containing epidermal growth factor (MS-EGF) and epidermal growth factor (EGF) alone group. VS: very satisfied, S: satisfied, SS: slightly satisfied, DS: dissatisfied.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5383744&req=5

Figure 4: Subjective evaluation of the treatment results on micro-spicule containing epidermal growth factor (MS-EGF) and epidermal growth factor (EGF) alone group. VS: very satisfied, S: satisfied, SS: slightly satisfied, DS: dissatisfied.
Mentions: Subjective improvement was also assessed by all participants upon completing the study. Among the participants who received MS-EGF treatment, 70% were “very satisfied” or “satisfied” after the treatment, whereas only 15% were “dissatisfied.” For the EGF alone group, 50% were “very satisfied” or “satisfied” after treatment whereas 20% were “dissatisfied” (Fig. 4). The treatments were well-tolerated by most patients and there were no noticeable adverse events such as inflammation, desquamation and pigmentation in either of the treated areas. Six participants in MS-EGF experienced transient erythema and a prickling sensation immediately after the application, which resolved within a few minutes without special management.

View Article: PubMed Central - PubMed

ABSTRACT

Background: Micro-needle patches have been recently used to increase skin permeability, which improves drug delivery, and for cosmetic purposes. However, these patches may often have limited efficacy due to insufficient skin penetration and reduced compliance caused by discomfort.

Objective: We evaluated the efficacy and the safety of soluble micro-spicule containing epidermal growth factor (MS-EGF) for the treatment of periocular wrinkles.

Methods: Twenty healthy volunteers aged 33 to 54 years were enrolled in a randomized, controlled, split-face study. For 4 weeks, a periocular wrinkle was treated daily with either a soluble MS-EGF cream or a cream containing EGF alone. All subjects underwent 8 weeks of follow-up. Efficacy was assessed using an ultrasonic measurement of dermal depth and density, digital skin image analysis, 5-point photonumeric scale for periocular wrinkles and subjective satisfaction.

Results: MS-EGF group showed statistically significant increase of dermal depth and density compared to EGF alone group after 4 and 8 weeks. In addition, there was a marked improvement shown in clinical and 3-dimensional skin image in MS-EGF group. The treatments were well-tolerated; no significant side-effect was noted.

Conclusion: The MS-EGF formulation may represent an effective and biocompatible advance in the treatment of periocular wrinkles.

No MeSH data available.