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The Effect of Micro-Spicule Containing Epidermal Growth Factor on Periocular Wrinkles

View Article: PubMed Central - PubMed

ABSTRACT

Background: Micro-needle patches have been recently used to increase skin permeability, which improves drug delivery, and for cosmetic purposes. However, these patches may often have limited efficacy due to insufficient skin penetration and reduced compliance caused by discomfort.

Objective: We evaluated the efficacy and the safety of soluble micro-spicule containing epidermal growth factor (MS-EGF) for the treatment of periocular wrinkles.

Methods: Twenty healthy volunteers aged 33 to 54 years were enrolled in a randomized, controlled, split-face study. For 4 weeks, a periocular wrinkle was treated daily with either a soluble MS-EGF cream or a cream containing EGF alone. All subjects underwent 8 weeks of follow-up. Efficacy was assessed using an ultrasonic measurement of dermal depth and density, digital skin image analysis, 5-point photonumeric scale for periocular wrinkles and subjective satisfaction.

Results: MS-EGF group showed statistically significant increase of dermal depth and density compared to EGF alone group after 4 and 8 weeks. In addition, there was a marked improvement shown in clinical and 3-dimensional skin image in MS-EGF group. The treatments were well-tolerated; no significant side-effect was noted.

Conclusion: The MS-EGF formulation may represent an effective and biocompatible advance in the treatment of periocular wrinkles.

No MeSH data available.


Related in: MedlinePlus

Clinical outcome of periocular wrinkle using digital skin image and wrinkle score. (A) Photographs showing clinical improvements of periocular wrinkles. One photograph was taken at baseline (left) and the other was taken 8 weeks after (right). (B) Three-dimensional analysis images of baseline (left) and 8 weeks after (right). Red color indicate upper high and blue color indicates lower high. (C) Wrinkle score using skin image analysis. (D) Wrinkle score using 5-point photonumeric scale. MS-EGF: micro-spicule containing epidermal growth factor, EGF: epidermal growth factor. *p<0.05, ***p<0.001.
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Figure 3: Clinical outcome of periocular wrinkle using digital skin image and wrinkle score. (A) Photographs showing clinical improvements of periocular wrinkles. One photograph was taken at baseline (left) and the other was taken 8 weeks after (right). (B) Three-dimensional analysis images of baseline (left) and 8 weeks after (right). Red color indicate upper high and blue color indicates lower high. (C) Wrinkle score using skin image analysis. (D) Wrinkle score using 5-point photonumeric scale. MS-EGF: micro-spicule containing epidermal growth factor, EGF: epidermal growth factor. *p<0.05, ***p<0.001.

Mentions: Clinical digital photographs and 3D image of periocular wrinkles by A-One Pro image analysis were used for clinical comparisons. Although both groups showed favorable results after 8 weeks compared to the baseline, the clinical photograph and 3D skin image improved significantly more with MS-EGF treatment than that for EGF alone treatment (Fig. 3A, B). Wrinkle severity score was evaluated automatically with A-One Pro, using a 5-point photonumeric scale. In the A-One Pro measurements, wrinkle scores decreased in both groups; however, the MS-EGF group showed significant improvement in wrinkle score compared to EGF alone group after 8 weeks (p<.0.05) (Fig. 3C). In the 5-point photonumeric scale, there was no significant difference in the grades between the two groups; however, the MS-EGF group showed a greater change in mean grade using this scale (2.5~2.0 in MS-EGF vs. 2.4~2.2 in EGF alone group; Fig. 3D).


The Effect of Micro-Spicule Containing Epidermal Growth Factor on Periocular Wrinkles
Clinical outcome of periocular wrinkle using digital skin image and wrinkle score. (A) Photographs showing clinical improvements of periocular wrinkles. One photograph was taken at baseline (left) and the other was taken 8 weeks after (right). (B) Three-dimensional analysis images of baseline (left) and 8 weeks after (right). Red color indicate upper high and blue color indicates lower high. (C) Wrinkle score using skin image analysis. (D) Wrinkle score using 5-point photonumeric scale. MS-EGF: micro-spicule containing epidermal growth factor, EGF: epidermal growth factor. *p<0.05, ***p<0.001.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5383744&req=5

Figure 3: Clinical outcome of periocular wrinkle using digital skin image and wrinkle score. (A) Photographs showing clinical improvements of periocular wrinkles. One photograph was taken at baseline (left) and the other was taken 8 weeks after (right). (B) Three-dimensional analysis images of baseline (left) and 8 weeks after (right). Red color indicate upper high and blue color indicates lower high. (C) Wrinkle score using skin image analysis. (D) Wrinkle score using 5-point photonumeric scale. MS-EGF: micro-spicule containing epidermal growth factor, EGF: epidermal growth factor. *p<0.05, ***p<0.001.
Mentions: Clinical digital photographs and 3D image of periocular wrinkles by A-One Pro image analysis were used for clinical comparisons. Although both groups showed favorable results after 8 weeks compared to the baseline, the clinical photograph and 3D skin image improved significantly more with MS-EGF treatment than that for EGF alone treatment (Fig. 3A, B). Wrinkle severity score was evaluated automatically with A-One Pro, using a 5-point photonumeric scale. In the A-One Pro measurements, wrinkle scores decreased in both groups; however, the MS-EGF group showed significant improvement in wrinkle score compared to EGF alone group after 8 weeks (p<.0.05) (Fig. 3C). In the 5-point photonumeric scale, there was no significant difference in the grades between the two groups; however, the MS-EGF group showed a greater change in mean grade using this scale (2.5~2.0 in MS-EGF vs. 2.4~2.2 in EGF alone group; Fig. 3D).

View Article: PubMed Central - PubMed

ABSTRACT

Background: Micro-needle patches have been recently used to increase skin permeability, which improves drug delivery, and for cosmetic purposes. However, these patches may often have limited efficacy due to insufficient skin penetration and reduced compliance caused by discomfort.

Objective: We evaluated the efficacy and the safety of soluble micro-spicule containing epidermal growth factor (MS-EGF) for the treatment of periocular wrinkles.

Methods: Twenty healthy volunteers aged 33 to 54 years were enrolled in a randomized, controlled, split-face study. For 4 weeks, a periocular wrinkle was treated daily with either a soluble MS-EGF cream or a cream containing EGF alone. All subjects underwent 8 weeks of follow-up. Efficacy was assessed using an ultrasonic measurement of dermal depth and density, digital skin image analysis, 5-point photonumeric scale for periocular wrinkles and subjective satisfaction.

Results: MS-EGF group showed statistically significant increase of dermal depth and density compared to EGF alone group after 4 and 8 weeks. In addition, there was a marked improvement shown in clinical and 3-dimensional skin image in MS-EGF group. The treatments were well-tolerated; no significant side-effect was noted.

Conclusion: The MS-EGF formulation may represent an effective and biocompatible advance in the treatment of periocular wrinkles.

No MeSH data available.


Related in: MedlinePlus