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The Effect of Micro-Spicule Containing Epidermal Growth Factor on Periocular Wrinkles

View Article: PubMed Central - PubMed

ABSTRACT

Background: Micro-needle patches have been recently used to increase skin permeability, which improves drug delivery, and for cosmetic purposes. However, these patches may often have limited efficacy due to insufficient skin penetration and reduced compliance caused by discomfort.

Objective: We evaluated the efficacy and the safety of soluble micro-spicule containing epidermal growth factor (MS-EGF) for the treatment of periocular wrinkles.

Methods: Twenty healthy volunteers aged 33 to 54 years were enrolled in a randomized, controlled, split-face study. For 4 weeks, a periocular wrinkle was treated daily with either a soluble MS-EGF cream or a cream containing EGF alone. All subjects underwent 8 weeks of follow-up. Efficacy was assessed using an ultrasonic measurement of dermal depth and density, digital skin image analysis, 5-point photonumeric scale for periocular wrinkles and subjective satisfaction.

Results: MS-EGF group showed statistically significant increase of dermal depth and density compared to EGF alone group after 4 and 8 weeks. In addition, there was a marked improvement shown in clinical and 3-dimensional skin image in MS-EGF group. The treatments were well-tolerated; no significant side-effect was noted.

Conclusion: The MS-EGF formulation may represent an effective and biocompatible advance in the treatment of periocular wrinkles.

No MeSH data available.


Measurement of dermal depth and density using skin ultrasound. (A) One ultrasound image was taken at baseline (left) and the other was taken 8 weeks after (right) for the micro-spicule containing epidermal growth factor (MS-EGF) and epidermal growth factor (EGF) alone group. Change of dermal density (B) and depth (C) ratio from baselines. *p<0.05, **p<0.01, ***p<0.001 vs. baseline; †p<0.05, ††p<0.01 vs. EGF.
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Figure 2: Measurement of dermal depth and density using skin ultrasound. (A) One ultrasound image was taken at baseline (left) and the other was taken 8 weeks after (right) for the micro-spicule containing epidermal growth factor (MS-EGF) and epidermal growth factor (EGF) alone group. Change of dermal density (B) and depth (C) ratio from baselines. *p<0.05, **p<0.01, ***p<0.001 vs. baseline; †p<0.05, ††p<0.01 vs. EGF.

Mentions: A randomized, controlled, left-right face spilt test was performed afterwards to test the efficacy of MS-EGF on periocular wrinkle. A total of 20 healthy volunteers (16 females, 4 males) with an average age of 45.2 years (range, 33~54 years) were enrolled in this study. There were no significant differences in the degree of baseline wrinkles between each group. After daily applications for each group for 4 weeks on each periocular wrinkle, the MS-EGF grouped showed a marked improvement at 8 weeks after topical application, shown with skin ultrasound analysis (Fig. 2A). The mean dermal density of both groups at baseline was similar (6.25%±1.73% in MS-EGF vs. 6.38%±1.55% in EGF alone) and this value was set as a standard of the dermal density ratio changes. In the MS-EGF group, dermal density ratio was significantly improved at 4 and 8 weeks after treatment, respectively (p<.0.01, p<.0.001). In the EGF alone group, there was a slight increase in dermal density, but the difference was not statistically significant. The MS-EGF group also demonstrated a significant increase in dermal density after 4 and 8 weeks compared to EGF alone group, respectively (p<.0.05, p<.0.01; Fig. 2B).


The Effect of Micro-Spicule Containing Epidermal Growth Factor on Periocular Wrinkles
Measurement of dermal depth and density using skin ultrasound. (A) One ultrasound image was taken at baseline (left) and the other was taken 8 weeks after (right) for the micro-spicule containing epidermal growth factor (MS-EGF) and epidermal growth factor (EGF) alone group. Change of dermal density (B) and depth (C) ratio from baselines. *p<0.05, **p<0.01, ***p<0.001 vs. baseline; †p<0.05, ††p<0.01 vs. EGF.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
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getmorefigures.php?uid=PMC5383744&req=5

Figure 2: Measurement of dermal depth and density using skin ultrasound. (A) One ultrasound image was taken at baseline (left) and the other was taken 8 weeks after (right) for the micro-spicule containing epidermal growth factor (MS-EGF) and epidermal growth factor (EGF) alone group. Change of dermal density (B) and depth (C) ratio from baselines. *p<0.05, **p<0.01, ***p<0.001 vs. baseline; †p<0.05, ††p<0.01 vs. EGF.
Mentions: A randomized, controlled, left-right face spilt test was performed afterwards to test the efficacy of MS-EGF on periocular wrinkle. A total of 20 healthy volunteers (16 females, 4 males) with an average age of 45.2 years (range, 33~54 years) were enrolled in this study. There were no significant differences in the degree of baseline wrinkles between each group. After daily applications for each group for 4 weeks on each periocular wrinkle, the MS-EGF grouped showed a marked improvement at 8 weeks after topical application, shown with skin ultrasound analysis (Fig. 2A). The mean dermal density of both groups at baseline was similar (6.25%±1.73% in MS-EGF vs. 6.38%±1.55% in EGF alone) and this value was set as a standard of the dermal density ratio changes. In the MS-EGF group, dermal density ratio was significantly improved at 4 and 8 weeks after treatment, respectively (p<.0.01, p<.0.001). In the EGF alone group, there was a slight increase in dermal density, but the difference was not statistically significant. The MS-EGF group also demonstrated a significant increase in dermal density after 4 and 8 weeks compared to EGF alone group, respectively (p<.0.05, p<.0.01; Fig. 2B).

View Article: PubMed Central - PubMed

ABSTRACT

Background: Micro-needle patches have been recently used to increase skin permeability, which improves drug delivery, and for cosmetic purposes. However, these patches may often have limited efficacy due to insufficient skin penetration and reduced compliance caused by discomfort.

Objective: We evaluated the efficacy and the safety of soluble micro-spicule containing epidermal growth factor (MS-EGF) for the treatment of periocular wrinkles.

Methods: Twenty healthy volunteers aged 33 to 54 years were enrolled in a randomized, controlled, split-face study. For 4 weeks, a periocular wrinkle was treated daily with either a soluble MS-EGF cream or a cream containing EGF alone. All subjects underwent 8 weeks of follow-up. Efficacy was assessed using an ultrasonic measurement of dermal depth and density, digital skin image analysis, 5-point photonumeric scale for periocular wrinkles and subjective satisfaction.

Results: MS-EGF group showed statistically significant increase of dermal depth and density compared to EGF alone group after 4 and 8 weeks. In addition, there was a marked improvement shown in clinical and 3-dimensional skin image in MS-EGF group. The treatments were well-tolerated; no significant side-effect was noted.

Conclusion: The MS-EGF formulation may represent an effective and biocompatible advance in the treatment of periocular wrinkles.

No MeSH data available.