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The Effect of Micro-Spicule Containing Epidermal Growth Factor on Periocular Wrinkles

View Article: PubMed Central - PubMed

ABSTRACT

Background: Micro-needle patches have been recently used to increase skin permeability, which improves drug delivery, and for cosmetic purposes. However, these patches may often have limited efficacy due to insufficient skin penetration and reduced compliance caused by discomfort.

Objective: We evaluated the efficacy and the safety of soluble micro-spicule containing epidermal growth factor (MS-EGF) for the treatment of periocular wrinkles.

Methods: Twenty healthy volunteers aged 33 to 54 years were enrolled in a randomized, controlled, split-face study. For 4 weeks, a periocular wrinkle was treated daily with either a soluble MS-EGF cream or a cream containing EGF alone. All subjects underwent 8 weeks of follow-up. Efficacy was assessed using an ultrasonic measurement of dermal depth and density, digital skin image analysis, 5-point photonumeric scale for periocular wrinkles and subjective satisfaction.

Results: MS-EGF group showed statistically significant increase of dermal depth and density compared to EGF alone group after 4 and 8 weeks. In addition, there was a marked improvement shown in clinical and 3-dimensional skin image in MS-EGF group. The treatments were well-tolerated; no significant side-effect was noted.

Conclusion: The MS-EGF formulation may represent an effective and biocompatible advance in the treatment of periocular wrinkles.

No MeSH data available.


Related in: MedlinePlus

Appearance and penetration assay of micro-spicule containing epidermal growth factor (MS-EGF). (A) A 0.25-µm-sized pyramidal shaped hollow spicule made of hyaluronic acid (left) and MS-EGF mixed with general hydrophobic cosmetic paste (right) (arrows: MS-EGF component, ×200). (B) Histological finding showing epidermal growth factor (EGF) expression in the skin after application of MS-EGF (anti-EGF stain, Scale bar=50 µm).
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Figure 1: Appearance and penetration assay of micro-spicule containing epidermal growth factor (MS-EGF). (A) A 0.25-µm-sized pyramidal shaped hollow spicule made of hyaluronic acid (left) and MS-EGF mixed with general hydrophobic cosmetic paste (right) (arrows: MS-EGF component, ×200). (B) Histological finding showing epidermal growth factor (EGF) expression in the skin after application of MS-EGF (anti-EGF stain, Scale bar=50 µm).

Mentions: MS-EGF is a 0.25-µm pyramidal shaped material composed of hyaluronic acid. This micro-spicule contains EGF and is readily soluble in water. MS-EGF cream is MS-EGF mixed with a general hydrophobic cosmetic paste (Fig. 1A).


The Effect of Micro-Spicule Containing Epidermal Growth Factor on Periocular Wrinkles
Appearance and penetration assay of micro-spicule containing epidermal growth factor (MS-EGF). (A) A 0.25-µm-sized pyramidal shaped hollow spicule made of hyaluronic acid (left) and MS-EGF mixed with general hydrophobic cosmetic paste (right) (arrows: MS-EGF component, ×200). (B) Histological finding showing epidermal growth factor (EGF) expression in the skin after application of MS-EGF (anti-EGF stain, Scale bar=50 µm).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5383744&req=5

Figure 1: Appearance and penetration assay of micro-spicule containing epidermal growth factor (MS-EGF). (A) A 0.25-µm-sized pyramidal shaped hollow spicule made of hyaluronic acid (left) and MS-EGF mixed with general hydrophobic cosmetic paste (right) (arrows: MS-EGF component, ×200). (B) Histological finding showing epidermal growth factor (EGF) expression in the skin after application of MS-EGF (anti-EGF stain, Scale bar=50 µm).
Mentions: MS-EGF is a 0.25-µm pyramidal shaped material composed of hyaluronic acid. This micro-spicule contains EGF and is readily soluble in water. MS-EGF cream is MS-EGF mixed with a general hydrophobic cosmetic paste (Fig. 1A).

View Article: PubMed Central - PubMed

ABSTRACT

Background: Micro-needle patches have been recently used to increase skin permeability, which improves drug delivery, and for cosmetic purposes. However, these patches may often have limited efficacy due to insufficient skin penetration and reduced compliance caused by discomfort.

Objective: We evaluated the efficacy and the safety of soluble micro-spicule containing epidermal growth factor (MS-EGF) for the treatment of periocular wrinkles.

Methods: Twenty healthy volunteers aged 33 to 54 years were enrolled in a randomized, controlled, split-face study. For 4 weeks, a periocular wrinkle was treated daily with either a soluble MS-EGF cream or a cream containing EGF alone. All subjects underwent 8 weeks of follow-up. Efficacy was assessed using an ultrasonic measurement of dermal depth and density, digital skin image analysis, 5-point photonumeric scale for periocular wrinkles and subjective satisfaction.

Results: MS-EGF group showed statistically significant increase of dermal depth and density compared to EGF alone group after 4 and 8 weeks. In addition, there was a marked improvement shown in clinical and 3-dimensional skin image in MS-EGF group. The treatments were well-tolerated; no significant side-effect was noted.

Conclusion: The MS-EGF formulation may represent an effective and biocompatible advance in the treatment of periocular wrinkles.

No MeSH data available.


Related in: MedlinePlus