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Biomarkers of Osteosarcoma, Chondrosarcoma, and Ewing Sarcoma

View Article: PubMed Central - PubMed

ABSTRACT

Osteosarcoma is the most frequent malignant bone neoplasm, followed by chondrosarcoma and Ewing sarcoma. The diagnosis of bone neoplasms is generally made through histological evaluation of a biopsy. Clinical and radiological features are also important in aiding diagnosis and to complete the staging of bone cancer. In addition to these, there are several non-specific serological or specific molecular markers for bone neoplasms. In bone tumors, molecular markers increase the accuracy of the diagnosis and assist in subtyping bone tumors. Here, we review these markers and discuss their role in the diagnosis and prognosis of the three most frequent malignant bone neoplasms, namely osteosarcoma, chondrosarcoma, and Ewing sarcoma.

No MeSH data available.


Related in: MedlinePlus

MiRNA genes that play a role in the development and progression of Osteosarcoma.
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Figure 1: MiRNA genes that play a role in the development and progression of Osteosarcoma.

Mentions: A study performed by the Massachusetts General Hospital group asserts that miR-199a-3p is involved in proliferative process of osteosarcoma. The restoration of this marker may provide therapeutic benefits in osteosarcoma. MicroRNAs (miRNA, miR) play an important role in cancer cell growth and migration. However, the potential roles of miRNAs in osteosarcoma remain largely uncharacterized. By applying a miRNA microarray platform and unsupervised hierarchical clustering analysis, they found that several miRNAs have altered expression levels in osteosarcoma cell lines and tumor tissues when compared with normal human osteoblasts. Three miRNAs, miR-199a-3p, miR-127-3p and miR-376c, were significantly decreased in osteosarcoma cell lines compared to osteoblasts, whereas miR-151-3p and miR-191 were increased in osteosarcoma cell lines (Duan et al., 2011) (Figure 1).


Biomarkers of Osteosarcoma, Chondrosarcoma, and Ewing Sarcoma
MiRNA genes that play a role in the development and progression of Osteosarcoma.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5383728&req=5

Figure 1: MiRNA genes that play a role in the development and progression of Osteosarcoma.
Mentions: A study performed by the Massachusetts General Hospital group asserts that miR-199a-3p is involved in proliferative process of osteosarcoma. The restoration of this marker may provide therapeutic benefits in osteosarcoma. MicroRNAs (miRNA, miR) play an important role in cancer cell growth and migration. However, the potential roles of miRNAs in osteosarcoma remain largely uncharacterized. By applying a miRNA microarray platform and unsupervised hierarchical clustering analysis, they found that several miRNAs have altered expression levels in osteosarcoma cell lines and tumor tissues when compared with normal human osteoblasts. Three miRNAs, miR-199a-3p, miR-127-3p and miR-376c, were significantly decreased in osteosarcoma cell lines compared to osteoblasts, whereas miR-151-3p and miR-191 were increased in osteosarcoma cell lines (Duan et al., 2011) (Figure 1).

View Article: PubMed Central - PubMed

ABSTRACT

Osteosarcoma is the most frequent malignant bone neoplasm, followed by chondrosarcoma and Ewing sarcoma. The diagnosis of bone neoplasms is generally made through histological evaluation of a biopsy. Clinical and radiological features are also important in aiding diagnosis and to complete the staging of bone cancer. In addition to these, there are several non-specific serological or specific molecular markers for bone neoplasms. In bone tumors, molecular markers increase the accuracy of the diagnosis and assist in subtyping bone tumors. Here, we review these markers and discuss their role in the diagnosis and prognosis of the three most frequent malignant bone neoplasms, namely osteosarcoma, chondrosarcoma, and Ewing sarcoma.

No MeSH data available.


Related in: MedlinePlus