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Discrepancies in Clinic and Ambulatory Blood Pressure in Korean Chronic Kidney Disease Patients

View Article: PubMed Central - PubMed

ABSTRACT

Blood pressure (BP) control is considered the most important treatment for preventing chronic kidney disease (CKD) progression and associated cardiovascular complications. However, clinic BP is insufficient to diagnose hypertension (HT) and to monitor overall BP control because it does not correlate well with ambulatory blood pressure monitoring (ABPM). We enrolled 387 hypertensive CKD patients (stages G1–G4, 58.4% male with median age 61 years) from 3 hospitals in Korea. HT of clinic BP and ABPM was classified as ≥ 140/90 and ≥ 130/80 mmHg, respectively. Clinic BP control rate was 60.2%. The median 24-hour systolic blood pressures (SBPs) of CKD G3b and CKD G4 were significantly higher than those of CKD G1–2 and CKD G3a. However, the median 24-hour SBPs were not different between CKD G1–2 and CKD G3a or between CKD G3b and CKD G4. Of all patients, 5.7%, 38.0%. 42.3%, and 14.0% were extreme-dippers, dippers, non-dippers, and reverse-dippers, respectively. Non-/reverse-dippers independently correlated with higher Ca × P product, higher intact parathyroid hormone (iPTH), and lower albumin. Normal BP was 33.3%, and sustained, masked, and white-coat HT were 29.7%, 26.9%, and 10.1%, respectively. White-coat HT independently correlated with age ≥ 61 years and masked HT independently correlated with CKD G3b/G4. In conclusion, ABPM revealed a high prevalence of non-/reverse-dippers and sustained/masked HT in Korean CKD patients. Clinicians should try to obtain a CKD patient's ABPM, especially among those who are older or who have advanced CKD as well as those with abnormal Ca × P product, iPTH, and albumin.

No MeSH data available.


Related in: MedlinePlus

Clinic BP values and ABPM SBPs values according to CKD stages.(A) Clinic SBP. (B) Clinic DBP. (C) 24-hour SBP. (D) Daytime SBP. (E) Nighttime SBP.BP = blood pressure, ABPM = ambulatory blood pressure monitoring, CKD = chronic kidney disease, DBP = diastolic blood pressure, SBP = systolic blood pressure.
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Figure 2: Clinic BP values and ABPM SBPs values according to CKD stages.(A) Clinic SBP. (B) Clinic DBP. (C) 24-hour SBP. (D) Daytime SBP. (E) Nighttime SBP.BP = blood pressure, ABPM = ambulatory blood pressure monitoring, CKD = chronic kidney disease, DBP = diastolic blood pressure, SBP = systolic blood pressure.

Mentions: The median clinic, 24-hour, daytime, and nighttime SBPs were not different between CKD G1–2 and CKD G3a. The median 24-hour, daytime, and nighttime SBPs were not different between CKD G3b and CKD G4. The median clinic diastolic blood pressure (DBP) of CKD G1–2 (80 [60–115] mmHg) was significantly higher than that of CKD G3a (80 [58–105] mmHg, P = 0.033), CKD G3b (78 [40–108] mmHg, P = 0.013), and CKD G4 (75 [30–104] mmHg, P = 0.001). There were no differences in the 24-hour, daytime, and nighttime DBP between all CKD stages (Fig. 2).


Discrepancies in Clinic and Ambulatory Blood Pressure in Korean Chronic Kidney Disease Patients
Clinic BP values and ABPM SBPs values according to CKD stages.(A) Clinic SBP. (B) Clinic DBP. (C) 24-hour SBP. (D) Daytime SBP. (E) Nighttime SBP.BP = blood pressure, ABPM = ambulatory blood pressure monitoring, CKD = chronic kidney disease, DBP = diastolic blood pressure, SBP = systolic blood pressure.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5383609&req=5

Figure 2: Clinic BP values and ABPM SBPs values according to CKD stages.(A) Clinic SBP. (B) Clinic DBP. (C) 24-hour SBP. (D) Daytime SBP. (E) Nighttime SBP.BP = blood pressure, ABPM = ambulatory blood pressure monitoring, CKD = chronic kidney disease, DBP = diastolic blood pressure, SBP = systolic blood pressure.
Mentions: The median clinic, 24-hour, daytime, and nighttime SBPs were not different between CKD G1–2 and CKD G3a. The median 24-hour, daytime, and nighttime SBPs were not different between CKD G3b and CKD G4. The median clinic diastolic blood pressure (DBP) of CKD G1–2 (80 [60–115] mmHg) was significantly higher than that of CKD G3a (80 [58–105] mmHg, P = 0.033), CKD G3b (78 [40–108] mmHg, P = 0.013), and CKD G4 (75 [30–104] mmHg, P = 0.001). There were no differences in the 24-hour, daytime, and nighttime DBP between all CKD stages (Fig. 2).

View Article: PubMed Central - PubMed

ABSTRACT

Blood pressure (BP) control is considered the most important treatment for preventing chronic kidney disease (CKD) progression and associated cardiovascular complications. However, clinic BP is insufficient to diagnose hypertension (HT) and to monitor overall BP control because it does not correlate well with ambulatory blood pressure monitoring (ABPM). We enrolled 387 hypertensive CKD patients (stages G1–G4, 58.4% male with median age 61 years) from 3 hospitals in Korea. HT of clinic BP and ABPM was classified as ≥ 140/90 and ≥ 130/80 mmHg, respectively. Clinic BP control rate was 60.2%. The median 24-hour systolic blood pressures (SBPs) of CKD G3b and CKD G4 were significantly higher than those of CKD G1–2 and CKD G3a. However, the median 24-hour SBPs were not different between CKD G1–2 and CKD G3a or between CKD G3b and CKD G4. Of all patients, 5.7%, 38.0%. 42.3%, and 14.0% were extreme-dippers, dippers, non-dippers, and reverse-dippers, respectively. Non-/reverse-dippers independently correlated with higher Ca × P product, higher intact parathyroid hormone (iPTH), and lower albumin. Normal BP was 33.3%, and sustained, masked, and white-coat HT were 29.7%, 26.9%, and 10.1%, respectively. White-coat HT independently correlated with age ≥ 61 years and masked HT independently correlated with CKD G3b/G4. In conclusion, ABPM revealed a high prevalence of non-/reverse-dippers and sustained/masked HT in Korean CKD patients. Clinicians should try to obtain a CKD patient's ABPM, especially among those who are older or who have advanced CKD as well as those with abnormal Ca × P product, iPTH, and albumin.

No MeSH data available.


Related in: MedlinePlus