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Effect of Coenzyme Q10 on Radiation Nephropathy in Rats

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ABSTRACT

The kidney is one of the most radiosensitive organs in the abdominal cavity and is the dose-limiting structure in cancer patients receiving abdominal or total body irradiation. In the present study, the effect of coenzyme Q10 (CoQ10) on radiation nephropathy was evaluated in rats. A total of 72 rats were equally randomized into 4 groups: Control, CoQ10, irradiation with 10 Gy (RT) + placebo, or RT + CoQ10. The 2 RT groups received single 10 Gy of abdominal irradiation. The 2 CoQ10 groups were supplemented daily with 1 mL of soybean oil containing 10 mg/kg of CoQ10. The RT + placebo and control groups received same dose of soybean oil. After 24 weeks, laboratory and histopathologic findings were compared. The 2 RT groups showed significant increases in blood urea nitrogen (BUN) and creatinine levels and significant pathologic changes such as glomerulosclerosis and tubulointerstitial fibrosis. CoQ10 supplementation resulted in significant reductions of BUN and creatinine levels compared with the RT + placebo group (P < 0.001 and P = 0.038, respectively). CoQ10 treatment significantly attenuated glomerular and tubular changes of irradiated kidney in semiquantitative analysis (P < 0.001 for both). Administration of CoQ10 can alleviate the radiation-induced nephropathy.

No MeSH data available.


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GSI in rats. Data represent means ± SD (n = 18 per group).GSI = glomerulosclerosis index, CoQ10 = coenzyme Q10, RT = irradiation with 10 Gy, SD = standard deviation.*P < 0.05, compared with the RT + placebo group; †P < 0.05, compared with the control group.
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Figure 1: GSI in rats. Data represent means ± SD (n = 18 per group).GSI = glomerulosclerosis index, CoQ10 = coenzyme Q10, RT = irradiation with 10 Gy, SD = standard deviation.*P < 0.05, compared with the RT + placebo group; †P < 0.05, compared with the control group.

Mentions: The kidney sections of the control and CoQ10 groups showed no obvious glomerular change and the mean GSI of them were measured as 0.08 ± 0.02 and 0.07 ± 0.02, respectively. Glomerular injury such as mesangiolysis and glomerulosclerosis were observed in the 2 RT groups. The mean GSI were 1.61 ± 0.26 in the RT + placebo group and 1.03 ± 0.29 in the RT + CoQ10. CoQ10 treatment significantly decreased the mean GSI of irradiated kidney (P < 0.001). The comparisons of glomerular changes of rat kidneys were displayed in Figs. 1 and 2.


Effect of Coenzyme Q10 on Radiation Nephropathy in Rats
GSI in rats. Data represent means ± SD (n = 18 per group).GSI = glomerulosclerosis index, CoQ10 = coenzyme Q10, RT = irradiation with 10 Gy, SD = standard deviation.*P < 0.05, compared with the RT + placebo group; †P < 0.05, compared with the control group.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5383607&req=5

Figure 1: GSI in rats. Data represent means ± SD (n = 18 per group).GSI = glomerulosclerosis index, CoQ10 = coenzyme Q10, RT = irradiation with 10 Gy, SD = standard deviation.*P < 0.05, compared with the RT + placebo group; †P < 0.05, compared with the control group.
Mentions: The kidney sections of the control and CoQ10 groups showed no obvious glomerular change and the mean GSI of them were measured as 0.08 ± 0.02 and 0.07 ± 0.02, respectively. Glomerular injury such as mesangiolysis and glomerulosclerosis were observed in the 2 RT groups. The mean GSI were 1.61 ± 0.26 in the RT + placebo group and 1.03 ± 0.29 in the RT + CoQ10. CoQ10 treatment significantly decreased the mean GSI of irradiated kidney (P < 0.001). The comparisons of glomerular changes of rat kidneys were displayed in Figs. 1 and 2.

View Article: PubMed Central - PubMed

ABSTRACT

The kidney is one of the most radiosensitive organs in the abdominal cavity and is the dose-limiting structure in cancer patients receiving abdominal or total body irradiation. In the present study, the effect of coenzyme Q10 (CoQ10) on radiation nephropathy was evaluated in rats. A total of 72 rats were equally randomized into 4 groups: Control, CoQ10, irradiation with 10 Gy (RT) + placebo, or RT + CoQ10. The 2 RT groups received single 10 Gy of abdominal irradiation. The 2 CoQ10 groups were supplemented daily with 1 mL of soybean oil containing 10 mg/kg of CoQ10. The RT + placebo and control groups received same dose of soybean oil. After 24 weeks, laboratory and histopathologic findings were compared. The 2 RT groups showed significant increases in blood urea nitrogen (BUN) and creatinine levels and significant pathologic changes such as glomerulosclerosis and tubulointerstitial fibrosis. CoQ10 supplementation resulted in significant reductions of BUN and creatinine levels compared with the RT + placebo group (P &lt; 0.001 and P = 0.038, respectively). CoQ10 treatment significantly attenuated glomerular and tubular changes of irradiated kidney in semiquantitative analysis (P &lt; 0.001 for both). Administration of CoQ10 can alleviate the radiation-induced nephropathy.

No MeSH data available.


Related in: MedlinePlus