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Epicardial Adipose Tissue Contributes to the Development of Non-Calcified Coronary Plaque: A 5-Year Computed Tomography Follow-up Study

View Article: PubMed Central - PubMed

ABSTRACT

Aim:: Epicardial adipose tissue (EAT) has been suggested as a contributing factor for coronary atherosclerosis based on the previous cross-sectional studies and pathophysiologic background. However, a causal relationship between EAT and the development of non-calcified coronary plaque (NCP) has not been investigated.

Methods:: A total of 122 asymptomatic individuals (age, 56.0 ± 7.6 years; male, 80.3%) without prior history of coronary artery disease (CAD) or metabolic syndrome and without NCP or obstructive CAD at baseline cardiac computed tomography (CT) were enrolled. Repeat cardiac CT was performed with an interval of more than 5 years. Epicardial fat volume index (EFVi; cm3/m2) was assessed in relation to the development of NCP on the follow-up CT where the results were classified into “calcified plaque (CP),” “no plaque,” and “NCP” groups.

Results:: On the follow-up CT performed with a median interval of 65.4 months, we observed newly developed NCP in 24 (19.7%) participants. Baseline EFVi was significantly higher in the NCP group (79.9 ± 30.3 cm3/m2) than in the CP group (63.7 ± 22.7 cm3/m2; P = 0.019) and in the no plaque group (62.5 ± 24.7 cm3/m2; P = 0.021). Multivariable logistic regression analysis demonstrated that the presence of diabetes (OR, 9.081; 95% CI, 1.682–49.034; P = 0.010) and the 3rd tertile of EFVi (OR, 4.297; 95% CI, 1.040–17.757; P = 0.044 compared to the 1st tertile) were the significant predictors for the development of NCP on follow-up CT.

Conclusions:: Greater amount of EAT at baseline CT independently predicts the development of NCP in asymptomatic individuals.

No MeSH data available.


Related in: MedlinePlus

Impact of EFVi on the development of coronary plaqueThe development of NCP on follow-up CT was observed more frequently among participants with increased EFVi at baseline. P-values were calculated by the χ2 test.Abbreviations: EFV, epicardial fat volume; CT, computed tomography; NCP, non-calcified plaque.
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Figure 2: Impact of EFVi on the development of coronary plaqueThe development of NCP on follow-up CT was observed more frequently among participants with increased EFVi at baseline. P-values were calculated by the χ2 test.Abbreviations: EFV, epicardial fat volume; CT, computed tomography; NCP, non-calcified plaque.

Mentions: Fig. 2 shows that there were significant differences in the proportions of participants in the NP, CP, and NCP groups in each tertile of baseline EFVi (overall P = 0.038). Among the participants in the 3rd tertile of baseline EFVi, 11 participants (29.3%) had NCP on the follow-up CT; 14 participants (22.5%) who were in the 2nd tertile at baseline and 16 participants (7.3%) who were in the 1st tertile at baseline had NCP on the follow-up CT (3rd tertile vs. 1st tertile, P = 0.020; 2nd tertile vs. 1st tertile, P = 0.067).


Epicardial Adipose Tissue Contributes to the Development of Non-Calcified Coronary Plaque: A 5-Year Computed Tomography Follow-up Study
Impact of EFVi on the development of coronary plaqueThe development of NCP on follow-up CT was observed more frequently among participants with increased EFVi at baseline. P-values were calculated by the χ2 test.Abbreviations: EFV, epicardial fat volume; CT, computed tomography; NCP, non-calcified plaque.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5383543&req=5

Figure 2: Impact of EFVi on the development of coronary plaqueThe development of NCP on follow-up CT was observed more frequently among participants with increased EFVi at baseline. P-values were calculated by the χ2 test.Abbreviations: EFV, epicardial fat volume; CT, computed tomography; NCP, non-calcified plaque.
Mentions: Fig. 2 shows that there were significant differences in the proportions of participants in the NP, CP, and NCP groups in each tertile of baseline EFVi (overall P = 0.038). Among the participants in the 3rd tertile of baseline EFVi, 11 participants (29.3%) had NCP on the follow-up CT; 14 participants (22.5%) who were in the 2nd tertile at baseline and 16 participants (7.3%) who were in the 1st tertile at baseline had NCP on the follow-up CT (3rd tertile vs. 1st tertile, P = 0.020; 2nd tertile vs. 1st tertile, P = 0.067).

View Article: PubMed Central - PubMed

ABSTRACT

Aim:: Epicardial adipose tissue (EAT) has been suggested as a contributing factor for coronary atherosclerosis based on the previous cross-sectional studies and pathophysiologic background. However, a causal relationship between EAT and the development of non-calcified coronary plaque (NCP) has not been investigated.

Methods:: A total of 122 asymptomatic individuals (age, 56.0 ± 7.6 years; male, 80.3%) without prior history of coronary artery disease (CAD) or metabolic syndrome and without NCP or obstructive CAD at baseline cardiac computed tomography (CT) were enrolled. Repeat cardiac CT was performed with an interval of more than 5 years. Epicardial fat volume index (EFVi; cm3/m2) was assessed in relation to the development of NCP on the follow-up CT where the results were classified into “calcified plaque (CP),” “no plaque,” and “NCP” groups.

Results:: On the follow-up CT performed with a median interval of 65.4 months, we observed newly developed NCP in 24 (19.7%) participants. Baseline EFVi was significantly higher in the NCP group (79.9 ± 30.3 cm3/m2) than in the CP group (63.7 ± 22.7 cm3/m2; P = 0.019) and in the no plaque group (62.5 ± 24.7 cm3/m2; P = 0.021). Multivariable logistic regression analysis demonstrated that the presence of diabetes (OR, 9.081; 95% CI, 1.682–49.034; P = 0.010) and the 3rd tertile of EFVi (OR, 4.297; 95% CI, 1.040–17.757; P = 0.044 compared to the 1st tertile) were the significant predictors for the development of NCP on follow-up CT.

Conclusions:: Greater amount of EAT at baseline CT independently predicts the development of NCP in asymptomatic individuals.

No MeSH data available.


Related in: MedlinePlus