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Multichannel perimetric alterations in systemic lupus erythematosus treated with hydroxychloroquine

View Article: PubMed Central - PubMed

ABSTRACT

Systemic lupus erythematosus (SLE) is a multiorgan autoimmune disease of unknown etiology with many clinical manifestations.

We report the first case of SLE in which visual alterations were evaluated with multichannel perimetry.

Some achromatic and color vision alterations may be present in SLE, especially when treated with hydroxychloroquine. The sensitivity losses detected in the chromatic channels in the central zone of the visual field were consistent with the results of the FM 100 Hue color test. Likewise, the multichannel perimetry detected sensitivity losses in the parafoveal area for both chromatic channels, especially for the blue-yellow.

No MeSH data available.


Achromatic contrast sensitivity function (CSF) obtained by means of the CSV-1000E test for both eyes.
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fig0005: Achromatic contrast sensitivity function (CSF) obtained by means of the CSV-1000E test for both eyes.

Mentions: We report the case of a visually asymptomatic 46-year old woman diagnosed with SLE and under treatment with hydroxychloquine during 15 years (hydroxychloroquine 200 mg/day). The right eye (RE) had a manifest refraction of −1.00 D and corrected distance visual acuity (CDVA) of 20/20. The left eye (LE) had a manifest refraction of (+4.00) (−1.75) 20° and CDVA of 20/25. Intraocular pressure was 12.7 and 13.3 mm Hg in RE and LE, respectively. Alterations were not detected either in the fundoscopic examination, 10-2 automated perimetry or in the examination of the macular structure by optical coherence tomography (Soct copernicus HR, Optopol). The results of the color vision examination (FM 100 Hue test) showed total and partial error score out of the range of normality for both eyes (RE: TES-128, RG-34, BY-94; LE: TES-144, RG-72, BY-72). The error value in the red-green (RG) axis was worse in LE, whereas the error value in the blue-yellow (BY) axis was worse in RE. Regarding the evaluation of the achromatic contrast sensitivity, a decrease in the contrast sensitivity function (CSF) was observed in both eyes for high spatial frequencies that was more significant in LE (Fig. 1). Besides these tests, visual perimetry was performed with a multichannel perimeter,6, 7, 8 selecting the following channels and frequencies to be examined9, 10:•


Multichannel perimetric alterations in systemic lupus erythematosus treated with hydroxychloroquine
Achromatic contrast sensitivity function (CSF) obtained by means of the CSV-1000E test for both eyes.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5383461&req=5

fig0005: Achromatic contrast sensitivity function (CSF) obtained by means of the CSV-1000E test for both eyes.
Mentions: We report the case of a visually asymptomatic 46-year old woman diagnosed with SLE and under treatment with hydroxychloquine during 15 years (hydroxychloroquine 200 mg/day). The right eye (RE) had a manifest refraction of −1.00 D and corrected distance visual acuity (CDVA) of 20/20. The left eye (LE) had a manifest refraction of (+4.00) (−1.75) 20° and CDVA of 20/25. Intraocular pressure was 12.7 and 13.3 mm Hg in RE and LE, respectively. Alterations were not detected either in the fundoscopic examination, 10-2 automated perimetry or in the examination of the macular structure by optical coherence tomography (Soct copernicus HR, Optopol). The results of the color vision examination (FM 100 Hue test) showed total and partial error score out of the range of normality for both eyes (RE: TES-128, RG-34, BY-94; LE: TES-144, RG-72, BY-72). The error value in the red-green (RG) axis was worse in LE, whereas the error value in the blue-yellow (BY) axis was worse in RE. Regarding the evaluation of the achromatic contrast sensitivity, a decrease in the contrast sensitivity function (CSF) was observed in both eyes for high spatial frequencies that was more significant in LE (Fig. 1). Besides these tests, visual perimetry was performed with a multichannel perimeter,6, 7, 8 selecting the following channels and frequencies to be examined9, 10:•

View Article: PubMed Central - PubMed

ABSTRACT

Systemic lupus erythematosus (SLE) is a multiorgan autoimmune disease of unknown etiology with many clinical manifestations.

We report the first case of SLE in which visual alterations were evaluated with multichannel perimetry.

Some achromatic and color vision alterations may be present in SLE, especially when treated with hydroxychloroquine. The sensitivity losses detected in the chromatic channels in the central zone of the visual field were consistent with the results of the FM 100 Hue color test. Likewise, the multichannel perimetry detected sensitivity losses in the parafoveal area for both chromatic channels, especially for the blue-yellow.

No MeSH data available.