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Enhanced thermal effect using magnetic nano-particles during high-intensity focused ultrasound

View Article: PubMed Central - PubMed

ABSTRACT

Collateral damage and long sonication times occurring during high-intensity focused ultrasound (HIFU) ablation procedures limit clinical advancement. In this reserarch, we investigated whether the use of magnetic nano-particles (mNPs) can reduce the power required to ablate tissue or, for the same power, reduce the duration of the procedure. Tissue-mimicking phantoms containing embedded thermocouples and physiologically acceptable concentrations (0%, 0.0047%, and 0.047%) of mNPs were sonicated at acoustic powers of 5.2 W, 9.2 W, and 14.5 W, for 30 seconds. Lesion volumes were determined for the phantoms with and without mNPs. It was found that with the 0.047% mNP concentration, the power required to obtain a lesion volume of 13 mm3 can be halved, and the time required to achieve a 21 mm3 lesion decreased by a factor of 5. We conclude that mNPs have the potential to reduce damage to healthy tissue, and reduce the procedure time, during tumor ablation using HIFU.

No MeSH data available.


Lesion volume for a sonication period of 30, 40, and 50 sec for a mNP concentration of 0.047% and acoustic power of 14.5 W.
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pone.0175093.g012: Lesion volume for a sonication period of 30, 40, and 50 sec for a mNP concentration of 0.047% and acoustic power of 14.5 W.

Mentions: The increased acoustic attenuation caused by the presence of nanoparticles led to a substantial increase in the temperature rise and the thermal dose (Figs 9 & 10) at the focal region inside the phantoms. The time to produce a 21 mm3 lesion decreased by about a factor of 5 with the addition of mNP’s in the 0.047% concentration. This represents a substantial time savings for clinical ablation procedures. Viewed another way, the power required to produce such a lesion in 30 seconds decreased by a factor of more than 2 (Fig 11), thereby reducing the risk of collateral damage to healthy tissue. Lesion volumes have been plotted by extrapolating the experimental data for the mNPs concentration of 0.047% and 14.5 W. The lesion volume increased by 1.8 and 2.4 times when the sonication time was increased to 40 and 50 sec, respectively, when compared to a sonication period of 30 sec (Fig 12).


Enhanced thermal effect using magnetic nano-particles during high-intensity focused ultrasound
Lesion volume for a sonication period of 30, 40, and 50 sec for a mNP concentration of 0.047% and acoustic power of 14.5 W.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5383424&req=5

pone.0175093.g012: Lesion volume for a sonication period of 30, 40, and 50 sec for a mNP concentration of 0.047% and acoustic power of 14.5 W.
Mentions: The increased acoustic attenuation caused by the presence of nanoparticles led to a substantial increase in the temperature rise and the thermal dose (Figs 9 & 10) at the focal region inside the phantoms. The time to produce a 21 mm3 lesion decreased by about a factor of 5 with the addition of mNP’s in the 0.047% concentration. This represents a substantial time savings for clinical ablation procedures. Viewed another way, the power required to produce such a lesion in 30 seconds decreased by a factor of more than 2 (Fig 11), thereby reducing the risk of collateral damage to healthy tissue. Lesion volumes have been plotted by extrapolating the experimental data for the mNPs concentration of 0.047% and 14.5 W. The lesion volume increased by 1.8 and 2.4 times when the sonication time was increased to 40 and 50 sec, respectively, when compared to a sonication period of 30 sec (Fig 12).

View Article: PubMed Central - PubMed

ABSTRACT

Collateral damage and long sonication times occurring during high-intensity focused ultrasound (HIFU) ablation procedures limit clinical advancement. In this reserarch, we investigated whether the use of magnetic nano-particles (mNPs) can reduce the power required to ablate tissue or, for the same power, reduce the duration of the procedure. Tissue-mimicking phantoms containing embedded thermocouples and physiologically acceptable concentrations (0%, 0.0047%, and 0.047%) of mNPs were sonicated at acoustic powers of 5.2 W, 9.2 W, and 14.5 W, for 30 seconds. Lesion volumes were determined for the phantoms with and without mNPs. It was found that with the 0.047% mNP concentration, the power required to obtain a lesion volume of 13 mm3 can be halved, and the time required to achieve a 21 mm3 lesion decreased by a factor of 5. We conclude that mNPs have the potential to reduce damage to healthy tissue, and reduce the procedure time, during tumor ablation using HIFU.

No MeSH data available.