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Enhanced thermal effect using magnetic nano-particles during high-intensity focused ultrasound

View Article: PubMed Central - PubMed

ABSTRACT

Collateral damage and long sonication times occurring during high-intensity focused ultrasound (HIFU) ablation procedures limit clinical advancement. In this reserarch, we investigated whether the use of magnetic nano-particles (mNPs) can reduce the power required to ablate tissue or, for the same power, reduce the duration of the procedure. Tissue-mimicking phantoms containing embedded thermocouples and physiologically acceptable concentrations (0%, 0.0047%, and 0.047%) of mNPs were sonicated at acoustic powers of 5.2 W, 9.2 W, and 14.5 W, for 30 seconds. Lesion volumes were determined for the phantoms with and without mNPs. It was found that with the 0.047% mNP concentration, the power required to obtain a lesion volume of 13 mm3 can be halved, and the time required to achieve a 21 mm3 lesion decreased by a factor of 5. We conclude that mNPs have the potential to reduce damage to healthy tissue, and reduce the procedure time, during tumor ablation using HIFU.

No MeSH data available.


Acoustic powers required to obtain a lesion volume of 13.5 mm3 for 0%, 0.0047%, and 0.047% mNPs at 1.025 MHz for a sonication period of 30 sec.
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pone.0175093.g011: Acoustic powers required to obtain a lesion volume of 13.5 mm3 for 0%, 0.0047%, and 0.047% mNPs at 1.025 MHz for a sonication period of 30 sec.

Mentions: The acoustic power required to achieve a lesion volume equal to 13 mm3—the volume achieved at the highest power level (14.5 W) and highest mNP concentration (0.047%)—was calculated for the two lower mNP concentrations (0%, 0.0047%). These powers, determined using the extrapolation method described in the previous section, are plotted in Fig 11. The 14.5 Watts required at the 0.047% mNP concentration increased to 22.8 Watts for a 0.0047% concentration, and to 36.6 W for no nanoparticles (S3 File).


Enhanced thermal effect using magnetic nano-particles during high-intensity focused ultrasound
Acoustic powers required to obtain a lesion volume of 13.5 mm3 for 0%, 0.0047%, and 0.047% mNPs at 1.025 MHz for a sonication period of 30 sec.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5383424&req=5

pone.0175093.g011: Acoustic powers required to obtain a lesion volume of 13.5 mm3 for 0%, 0.0047%, and 0.047% mNPs at 1.025 MHz for a sonication period of 30 sec.
Mentions: The acoustic power required to achieve a lesion volume equal to 13 mm3—the volume achieved at the highest power level (14.5 W) and highest mNP concentration (0.047%)—was calculated for the two lower mNP concentrations (0%, 0.0047%). These powers, determined using the extrapolation method described in the previous section, are plotted in Fig 11. The 14.5 Watts required at the 0.047% mNP concentration increased to 22.8 Watts for a 0.0047% concentration, and to 36.6 W for no nanoparticles (S3 File).

View Article: PubMed Central - PubMed

ABSTRACT

Collateral damage and long sonication times occurring during high-intensity focused ultrasound (HIFU) ablation procedures limit clinical advancement. In this reserarch, we investigated whether the use of magnetic nano-particles (mNPs) can reduce the power required to ablate tissue or, for the same power, reduce the duration of the procedure. Tissue-mimicking phantoms containing embedded thermocouples and physiologically acceptable concentrations (0%, 0.0047%, and 0.047%) of mNPs were sonicated at acoustic powers of 5.2 W, 9.2 W, and 14.5 W, for 30 seconds. Lesion volumes were determined for the phantoms with and without mNPs. It was found that with the 0.047% mNP concentration, the power required to obtain a lesion volume of 13 mm3 can be halved, and the time required to achieve a 21 mm3 lesion decreased by a factor of 5. We conclude that mNPs have the potential to reduce damage to healthy tissue, and reduce the procedure time, during tumor ablation using HIFU.

No MeSH data available.