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Enhanced thermal effect using magnetic nano-particles during high-intensity focused ultrasound

View Article: PubMed Central - PubMed

ABSTRACT

Collateral damage and long sonication times occurring during high-intensity focused ultrasound (HIFU) ablation procedures limit clinical advancement. In this reserarch, we investigated whether the use of magnetic nano-particles (mNPs) can reduce the power required to ablate tissue or, for the same power, reduce the duration of the procedure. Tissue-mimicking phantoms containing embedded thermocouples and physiologically acceptable concentrations (0%, 0.0047%, and 0.047%) of mNPs were sonicated at acoustic powers of 5.2 W, 9.2 W, and 14.5 W, for 30 seconds. Lesion volumes were determined for the phantoms with and without mNPs. It was found that with the 0.047% mNP concentration, the power required to obtain a lesion volume of 13 mm3 can be halved, and the time required to achieve a 21 mm3 lesion decreased by a factor of 5. We conclude that mNPs have the potential to reduce damage to healthy tissue, and reduce the procedure time, during tumor ablation using HIFU.

No MeSH data available.


Thermal dose at the focus for 5.2, 9.2, and 14.5 W acoustic powers and 0%, 0.0047%, and 0.047% concentrations of mNPs (Y-axis is in log scale).
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pone.0175093.g010: Thermal dose at the focus for 5.2, 9.2, and 14.5 W acoustic powers and 0%, 0.0047%, and 0.047% concentrations of mNPs (Y-axis is in log scale).

Mentions: The thermal dose at the beam focus was computed using Eqs (2 and 3). The computed thermal doses are plotted on a logarithmic scale in Fig 10. The thermal dose at the beam focus increased between 1 and 4 orders of magnitude relative to no mNP’s for the 0.0047% mNP level and 5 to 8 orders of magnitude for the 0.047% mNP level (S2 File).


Enhanced thermal effect using magnetic nano-particles during high-intensity focused ultrasound
Thermal dose at the focus for 5.2, 9.2, and 14.5 W acoustic powers and 0%, 0.0047%, and 0.047% concentrations of mNPs (Y-axis is in log scale).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5383424&req=5

pone.0175093.g010: Thermal dose at the focus for 5.2, 9.2, and 14.5 W acoustic powers and 0%, 0.0047%, and 0.047% concentrations of mNPs (Y-axis is in log scale).
Mentions: The thermal dose at the beam focus was computed using Eqs (2 and 3). The computed thermal doses are plotted on a logarithmic scale in Fig 10. The thermal dose at the beam focus increased between 1 and 4 orders of magnitude relative to no mNP’s for the 0.0047% mNP level and 5 to 8 orders of magnitude for the 0.047% mNP level (S2 File).

View Article: PubMed Central - PubMed

ABSTRACT

Collateral damage and long sonication times occurring during high-intensity focused ultrasound (HIFU) ablation procedures limit clinical advancement. In this reserarch, we investigated whether the use of magnetic nano-particles (mNPs) can reduce the power required to ablate tissue or, for the same power, reduce the duration of the procedure. Tissue-mimicking phantoms containing embedded thermocouples and physiologically acceptable concentrations (0%, 0.0047%, and 0.047%) of mNPs were sonicated at acoustic powers of 5.2 W, 9.2 W, and 14.5 W, for 30 seconds. Lesion volumes were determined for the phantoms with and without mNPs. It was found that with the 0.047% mNP concentration, the power required to obtain a lesion volume of 13 mm3 can be halved, and the time required to achieve a 21 mm3 lesion decreased by a factor of 5. We conclude that mNPs have the potential to reduce damage to healthy tissue, and reduce the procedure time, during tumor ablation using HIFU.

No MeSH data available.