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Enhanced thermal effect using magnetic nano-particles during high-intensity focused ultrasound

View Article: PubMed Central - PubMed

ABSTRACT

Collateral damage and long sonication times occurring during high-intensity focused ultrasound (HIFU) ablation procedures limit clinical advancement. In this reserarch, we investigated whether the use of magnetic nano-particles (mNPs) can reduce the power required to ablate tissue or, for the same power, reduce the duration of the procedure. Tissue-mimicking phantoms containing embedded thermocouples and physiologically acceptable concentrations (0%, 0.0047%, and 0.047%) of mNPs were sonicated at acoustic powers of 5.2 W, 9.2 W, and 14.5 W, for 30 seconds. Lesion volumes were determined for the phantoms with and without mNPs. It was found that with the 0.047% mNP concentration, the power required to obtain a lesion volume of 13 mm3 can be halved, and the time required to achieve a 21 mm3 lesion decreased by a factor of 5. We conclude that mNPs have the potential to reduce damage to healthy tissue, and reduce the procedure time, during tumor ablation using HIFU.

No MeSH data available.


Temperature variation with time at focus in tissue phantoms with 0%, 0.0047%, and 0.047% mNPs concentrations using acoustic power of (A) 5.2 W, (B) 9.2 W, and (C) 14.5 W for a sonication of 30 sec.
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pone.0175093.g008: Temperature variation with time at focus in tissue phantoms with 0%, 0.0047%, and 0.047% mNPs concentrations using acoustic power of (A) 5.2 W, (B) 9.2 W, and (C) 14.5 W for a sonication of 30 sec.

Mentions: Fig 8 shows the HIFU-induced focal temperature variations with time for the three mNP concentrations and three power levels. The focal temperatures were derived using Eq (1), according to the procedure of the previous section. The end-of-sonication temperatures are plotted in Fig 9. At the two higher powers, the end-of-sonication temperature for the 0.047% mNP concentration is approximately double that for the control case (0% mNP). The temperature rise for the 0.0047% concentration is within 20% of the temperature rise for the control phantom, at all powers (S1 File).


Enhanced thermal effect using magnetic nano-particles during high-intensity focused ultrasound
Temperature variation with time at focus in tissue phantoms with 0%, 0.0047%, and 0.047% mNPs concentrations using acoustic power of (A) 5.2 W, (B) 9.2 W, and (C) 14.5 W for a sonication of 30 sec.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5383424&req=5

pone.0175093.g008: Temperature variation with time at focus in tissue phantoms with 0%, 0.0047%, and 0.047% mNPs concentrations using acoustic power of (A) 5.2 W, (B) 9.2 W, and (C) 14.5 W for a sonication of 30 sec.
Mentions: Fig 8 shows the HIFU-induced focal temperature variations with time for the three mNP concentrations and three power levels. The focal temperatures were derived using Eq (1), according to the procedure of the previous section. The end-of-sonication temperatures are plotted in Fig 9. At the two higher powers, the end-of-sonication temperature for the 0.047% mNP concentration is approximately double that for the control case (0% mNP). The temperature rise for the 0.0047% concentration is within 20% of the temperature rise for the control phantom, at all powers (S1 File).

View Article: PubMed Central - PubMed

ABSTRACT

Collateral damage and long sonication times occurring during high-intensity focused ultrasound (HIFU) ablation procedures limit clinical advancement. In this reserarch, we investigated whether the use of magnetic nano-particles (mNPs) can reduce the power required to ablate tissue or, for the same power, reduce the duration of the procedure. Tissue-mimicking phantoms containing embedded thermocouples and physiologically acceptable concentrations (0%, 0.0047%, and 0.047%) of mNPs were sonicated at acoustic powers of 5.2 W, 9.2 W, and 14.5 W, for 30 seconds. Lesion volumes were determined for the phantoms with and without mNPs. It was found that with the 0.047% mNP concentration, the power required to obtain a lesion volume of 13 mm3 can be halved, and the time required to achieve a 21 mm3 lesion decreased by a factor of 5. We conclude that mNPs have the potential to reduce damage to healthy tissue, and reduce the procedure time, during tumor ablation using HIFU.

No MeSH data available.