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Enhanced thermal effect using magnetic nano-particles during high-intensity focused ultrasound

View Article: PubMed Central - PubMed

ABSTRACT

Collateral damage and long sonication times occurring during high-intensity focused ultrasound (HIFU) ablation procedures limit clinical advancement. In this reserarch, we investigated whether the use of magnetic nano-particles (mNPs) can reduce the power required to ablate tissue or, for the same power, reduce the duration of the procedure. Tissue-mimicking phantoms containing embedded thermocouples and physiologically acceptable concentrations (0%, 0.0047%, and 0.047%) of mNPs were sonicated at acoustic powers of 5.2 W, 9.2 W, and 14.5 W, for 30 seconds. Lesion volumes were determined for the phantoms with and without mNPs. It was found that with the 0.047% mNP concentration, the power required to obtain a lesion volume of 13 mm3 can be halved, and the time required to achieve a 21 mm3 lesion decreased by a factor of 5. We conclude that mNPs have the potential to reduce damage to healthy tissue, and reduce the procedure time, during tumor ablation using HIFU.

No MeSH data available.


Experimental setup showing the transducer, phantom and the DAQ.
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pone.0175093.g002: Experimental setup showing the transducer, phantom and the DAQ.

Mentions: Fig 2 shows the experimental setup used for performing HIFU sonications. An H102 transducer (Sonic Concepts Inc., Bothell, WA) with a focal length of 6.26 cm, outer diameter of 6.4 cm, and inner diameter of 2.2 cm was used as the source of the ultrasound. The transducer was driven in continuous-wave mode by a signal generator (33220A, Agilent Technologies) with an operating frequency of 1.025 MHz. A 150-Watt amplifier (150A100B, Amplifier Research) was used to amplify the signal. Both the transducer and the phantom were kept submerged inside degassed water during the experiments. The transducer was attached to a positioning system which was capable of adjusting any of the coordinates (x, y, and z) in discrete 0.025 mm increments.


Enhanced thermal effect using magnetic nano-particles during high-intensity focused ultrasound
Experimental setup showing the transducer, phantom and the DAQ.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5383424&req=5

pone.0175093.g002: Experimental setup showing the transducer, phantom and the DAQ.
Mentions: Fig 2 shows the experimental setup used for performing HIFU sonications. An H102 transducer (Sonic Concepts Inc., Bothell, WA) with a focal length of 6.26 cm, outer diameter of 6.4 cm, and inner diameter of 2.2 cm was used as the source of the ultrasound. The transducer was driven in continuous-wave mode by a signal generator (33220A, Agilent Technologies) with an operating frequency of 1.025 MHz. A 150-Watt amplifier (150A100B, Amplifier Research) was used to amplify the signal. Both the transducer and the phantom were kept submerged inside degassed water during the experiments. The transducer was attached to a positioning system which was capable of adjusting any of the coordinates (x, y, and z) in discrete 0.025 mm increments.

View Article: PubMed Central - PubMed

ABSTRACT

Collateral damage and long sonication times occurring during high-intensity focused ultrasound (HIFU) ablation procedures limit clinical advancement. In this reserarch, we investigated whether the use of magnetic nano-particles (mNPs) can reduce the power required to ablate tissue or, for the same power, reduce the duration of the procedure. Tissue-mimicking phantoms containing embedded thermocouples and physiologically acceptable concentrations (0%, 0.0047%, and 0.047%) of mNPs were sonicated at acoustic powers of 5.2 W, 9.2 W, and 14.5 W, for 30 seconds. Lesion volumes were determined for the phantoms with and without mNPs. It was found that with the 0.047% mNP concentration, the power required to obtain a lesion volume of 13 mm3 can be halved, and the time required to achieve a 21 mm3 lesion decreased by a factor of 5. We conclude that mNPs have the potential to reduce damage to healthy tissue, and reduce the procedure time, during tumor ablation using HIFU.

No MeSH data available.