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Association between fibromyalgia syndrome and peptic ulcer disease development

View Article: PubMed Central - PubMed

ABSTRACT

Purpose: The correlation of fibromyalgia syndrome (FMS) with peptic ulcer disease (PUD) is unclear. We therefore conducted a cohort study to investigate whether FMS is correlated with an increased risk of PUD.

Methods: In this study, we established an FMS cohort comprising 26068 patients aged more than 20 years who were diagnosed with FMS from 2000 to 2011. Furthermore, we established a control cohort by randomly choosing 104269 people without FMS who were matched to the FMS patients by gender, age, and index year. All patients were free of PUD at the baseline. Cox proportional hazard regressions were performed to compute the hazard ratio of PUD after adjustment for demographic characteristics and comorbidities.

Results: The prevalence of comorbidities was significantly higher in the FMS patients than in the controls. The incidence of PUD was 29.8 and 19.4 per 1000 person-years in the FMS and control cohorts, respectively. In addition, the FMS cohort exhibited a 1.40-fold higher risk of PUD (95% confidence interval = 1.35–1.45) compared with the control cohort. After control for confounding factors, the medications (selective serotonin reuptake inhibitors, serotonin–norepinephrine reuptake inhibitors, and antidepressants) taken by the FMS patients did not increase the risk of PUD.

Conclusion: FMS patients exhibit a higher risk of PUD than that of patients without FMS.

No MeSH data available.


Related in: MedlinePlus

Comparison of cumulative incidence of peptic ulcer disease in patients with (dashed line) and those without (solid line) fibromyalgia syndrome.
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pone.0175370.g001: Comparison of cumulative incidence of peptic ulcer disease in patients with (dashed line) and those without (solid line) fibromyalgia syndrome.

Mentions: A total of 26068 FMS patients and 104269 controls were included in this study (Table 1). Most patients were aged ≤49 years (53.8%) and were women (54.6%). The mean ages of the FMS and control cohorts were 49.5 ± 16.0 and 49.0 ± 16.3 years, respectively. The comorbidities of hyperlipidemia, diabetes, liver cirrhosis, alcohol-related illness, hypertension, depression, anxiety, sleep disorder, stroke, and GERD and NSAID use were more prevalent in the FMS cohort than in the control cohort. The average follow-up durations were 5.59 and 5.87 years in the FMS and control FMS cohorts, respectively. As shown in Fig 1, the cumulative incidence of PUD was higher in the FMS cohort than in the control cohort (log-rank test P < 0.001).


Association between fibromyalgia syndrome and peptic ulcer disease development
Comparison of cumulative incidence of peptic ulcer disease in patients with (dashed line) and those without (solid line) fibromyalgia syndrome.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5383298&req=5

pone.0175370.g001: Comparison of cumulative incidence of peptic ulcer disease in patients with (dashed line) and those without (solid line) fibromyalgia syndrome.
Mentions: A total of 26068 FMS patients and 104269 controls were included in this study (Table 1). Most patients were aged ≤49 years (53.8%) and were women (54.6%). The mean ages of the FMS and control cohorts were 49.5 ± 16.0 and 49.0 ± 16.3 years, respectively. The comorbidities of hyperlipidemia, diabetes, liver cirrhosis, alcohol-related illness, hypertension, depression, anxiety, sleep disorder, stroke, and GERD and NSAID use were more prevalent in the FMS cohort than in the control cohort. The average follow-up durations were 5.59 and 5.87 years in the FMS and control FMS cohorts, respectively. As shown in Fig 1, the cumulative incidence of PUD was higher in the FMS cohort than in the control cohort (log-rank test P < 0.001).

View Article: PubMed Central - PubMed

ABSTRACT

Purpose: The correlation of fibromyalgia syndrome (FMS) with peptic ulcer disease (PUD) is unclear. We therefore conducted a cohort study to investigate whether FMS is correlated with an increased risk of PUD.

Methods: In this study, we established an FMS cohort comprising 26068 patients aged more than 20 years who were diagnosed with FMS from 2000 to 2011. Furthermore, we established a control cohort by randomly choosing 104269 people without FMS who were matched to the FMS patients by gender, age, and index year. All patients were free of PUD at the baseline. Cox proportional hazard regressions were performed to compute the hazard ratio of PUD after adjustment for demographic characteristics and comorbidities.

Results: The prevalence of comorbidities was significantly higher in the FMS patients than in the controls. The incidence of PUD was 29.8 and 19.4 per 1000 person-years in the FMS and control cohorts, respectively. In addition, the FMS cohort exhibited a 1.40-fold higher risk of PUD (95% confidence interval = 1.35&ndash;1.45) compared with the control cohort. After control for confounding factors, the medications (selective serotonin reuptake inhibitors, serotonin&ndash;norepinephrine reuptake inhibitors, and antidepressants) taken by the FMS patients did not increase the risk of PUD.

Conclusion: FMS patients exhibit a higher risk of PUD than that of patients without FMS.

No MeSH data available.


Related in: MedlinePlus