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Differential modulation of thalamo-parietal interactions by varying depths of isoflurane anesthesia

View Article: PubMed Central - PubMed

ABSTRACT

The thalamus is thought to relay peripheral sensory information to the somatosensory cortex in the parietal lobe. Long-range thalamo-parietal interactions play an important role in inducing the effect of anesthetic. However, whether these interaction changes vary with different levels of anesthesia is not known. In the present study, we investigated the influence of different levels of isoflurane-induced anesthesia on the functional connectivity between the thalamus and the parietal region. Microelectrodes were implanted in rats to record local field potentials (LFPs). The rats underwent different levels of isoflurane anesthesia [deep anesthesia: isoflurane (ISO) 2.5 vol%, light anesthesia (ISO 1 vol%), awake, and recovery state] and LFPs were recorded from four different brain areas (left parietal, right parietal, left thalamus, and right thalamus). Partial directed coherence (PDC) was calculated for these areas. With increasing depth of anesthesia, the PDC in the thalamus-to-parietal direction was significantly increased mainly in the high frequency ranges; however, in the parietal-to-thalamus direction, the increase was mainly in the low frequency band. For both directions, the PDC changes were prominent in the alpha frequency band. Functional interactions between the thalamus and parietal area are augmented proportionally to the anesthesia level. This relationship may pave the way for better understanding of the neural processing of sensory inputs from the periphery under different levels of anesthesia.

No MeSH data available.


Estimated connectivity of the parietal area and thalamus using PDC.The solid line indicates an increase in connectivity between the two areas. The frequency shown on the line indicates the frequency bands between the two areas that are statistically significant (P < 0.05). T: thalamus, P: parietal area.
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pone.0175191.g005: Estimated connectivity of the parietal area and thalamus using PDC.The solid line indicates an increase in connectivity between the two areas. The frequency shown on the line indicates the frequency bands between the two areas that are statistically significant (P < 0.05). T: thalamus, P: parietal area.

Mentions: Taken together, these results suggest that the pattern of connectivity between parietal and thalamic regions is influenced by the depth of anesthesia (Fig 5).


Differential modulation of thalamo-parietal interactions by varying depths of isoflurane anesthesia
Estimated connectivity of the parietal area and thalamus using PDC.The solid line indicates an increase in connectivity between the two areas. The frequency shown on the line indicates the frequency bands between the two areas that are statistically significant (P < 0.05). T: thalamus, P: parietal area.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5383263&req=5

pone.0175191.g005: Estimated connectivity of the parietal area and thalamus using PDC.The solid line indicates an increase in connectivity between the two areas. The frequency shown on the line indicates the frequency bands between the two areas that are statistically significant (P < 0.05). T: thalamus, P: parietal area.
Mentions: Taken together, these results suggest that the pattern of connectivity between parietal and thalamic regions is influenced by the depth of anesthesia (Fig 5).

View Article: PubMed Central - PubMed

ABSTRACT

The thalamus is thought to relay peripheral sensory information to the somatosensory cortex in the parietal lobe. Long-range thalamo-parietal interactions play an important role in inducing the effect of anesthetic. However, whether these interaction changes vary with different levels of anesthesia is not known. In the present study, we investigated the influence of different levels of isoflurane-induced anesthesia on the functional connectivity between the thalamus and the parietal region. Microelectrodes were implanted in rats to record local field potentials (LFPs). The rats underwent different levels of isoflurane anesthesia [deep anesthesia: isoflurane (ISO) 2.5 vol%, light anesthesia (ISO 1 vol%), awake, and recovery state] and LFPs were recorded from four different brain areas (left parietal, right parietal, left thalamus, and right thalamus). Partial directed coherence (PDC) was calculated for these areas. With increasing depth of anesthesia, the PDC in the thalamus-to-parietal direction was significantly increased mainly in the high frequency ranges; however, in the parietal-to-thalamus direction, the increase was mainly in the low frequency band. For both directions, the PDC changes were prominent in the alpha frequency band. Functional interactions between the thalamus and parietal area are augmented proportionally to the anesthesia level. This relationship may pave the way for better understanding of the neural processing of sensory inputs from the periphery under different levels of anesthesia.

No MeSH data available.