Limits...
A dose-response relationship of smoking with tuberculosis infection: A cross-sectional study among 21008 rural residents in China

View Article: PubMed Central - PubMed

ABSTRACT

Objectives: China has high burden on both of tuberculosis (TB) and tobacco use. This study aims to explore the potential link between smoking and TB infection using baseline survey data of a large-scale population-based prospective study in rural China

Methods: Between July 1 and Sept 30, 2013, based on the baseline survey of a population-based, prospective study in rural China, the relationship between smoking and TB infection, assessed by interferon-gamma release assays (IGRA), was investigated among the total study population and only among those smokers, respectively.

Results: A total of 21,008 eligible rural registered residents (≥ 5 years old) from 4 rural sites were included in the analysis. Ever-smokers were more likely to be QuantiFERON-TB Gold In-Tube (QFT) positive than never smokers with an adjusted odds ratio (OR) of 1.34 (95% confidence interval (CI): 1.21–1.49). Among ever smokers, a significant linear dose–response relation was observed between duration of smoking (by years) and QFT positivity (p < 0.001). Stratified analysis suggested that such an association was not influenced by gender and age. Evidence for interaction of smoking status with age was found.

Conclusions: Our results provide further evidence to support smoking might increase host susceptibility to TB infection. Populations under high risk of infection, such as elderly smokers, should be prior to TB infection controlling under a premise of community level intervention.

No MeSH data available.


Related in: MedlinePlus

Association of QFT positivity with smoking years among smokers.Multiple logistic regression analysis was conducted to assess the association of smoking years with QFT positivity. Variables with p < 0.05 in univariate analysis were included in the model. Gender, age, education level, history of close contact with tuberculosis patients, alcohol drinking, number of cigarettes smoked per day were adjusted. Adjusted odds ratio (ORs) and the 95% confidence intervals (CIs) were given in the figure. Abbreviations: CI = confidence interval; QFT = QuantiFERON-TB Gold In-Tube.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC5383252&req=5

pone.0175183.g002: Association of QFT positivity with smoking years among smokers.Multiple logistic regression analysis was conducted to assess the association of smoking years with QFT positivity. Variables with p < 0.05 in univariate analysis were included in the model. Gender, age, education level, history of close contact with tuberculosis patients, alcohol drinking, number of cigarettes smoked per day were adjusted. Adjusted odds ratio (ORs) and the 95% confidence intervals (CIs) were given in the figure. Abbreviations: CI = confidence interval; QFT = QuantiFERON-TB Gold In-Tube.

Mentions: Factors associated with QFT positivity among smokers were shown in Table 3. An increasing TB infection risk was observed to be positively related to ages of 60 years or older, history of close contact with TB patients and duration of smoking years. In addition, as shown in Fig 2, a significant dose–response relation between QFT positivity and duration of smoking years was observed among smokers (p trend = 0.001).


A dose-response relationship of smoking with tuberculosis infection: A cross-sectional study among 21008 rural residents in China
Association of QFT positivity with smoking years among smokers.Multiple logistic regression analysis was conducted to assess the association of smoking years with QFT positivity. Variables with p < 0.05 in univariate analysis were included in the model. Gender, age, education level, history of close contact with tuberculosis patients, alcohol drinking, number of cigarettes smoked per day were adjusted. Adjusted odds ratio (ORs) and the 95% confidence intervals (CIs) were given in the figure. Abbreviations: CI = confidence interval; QFT = QuantiFERON-TB Gold In-Tube.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5383252&req=5

pone.0175183.g002: Association of QFT positivity with smoking years among smokers.Multiple logistic regression analysis was conducted to assess the association of smoking years with QFT positivity. Variables with p < 0.05 in univariate analysis were included in the model. Gender, age, education level, history of close contact with tuberculosis patients, alcohol drinking, number of cigarettes smoked per day were adjusted. Adjusted odds ratio (ORs) and the 95% confidence intervals (CIs) were given in the figure. Abbreviations: CI = confidence interval; QFT = QuantiFERON-TB Gold In-Tube.
Mentions: Factors associated with QFT positivity among smokers were shown in Table 3. An increasing TB infection risk was observed to be positively related to ages of 60 years or older, history of close contact with TB patients and duration of smoking years. In addition, as shown in Fig 2, a significant dose–response relation between QFT positivity and duration of smoking years was observed among smokers (p trend = 0.001).

View Article: PubMed Central - PubMed

ABSTRACT

Objectives: China has high burden on both of tuberculosis (TB) and tobacco use. This study aims to explore the potential link between smoking and TB infection using baseline survey data of a large-scale population-based prospective study in rural China

Methods: Between July 1 and Sept 30, 2013, based on the baseline survey of a population-based, prospective study in rural China, the relationship between smoking and TB infection, assessed by interferon-gamma release assays (IGRA), was investigated among the total study population and only among those smokers, respectively.

Results: A total of 21,008 eligible rural registered residents (&ge; 5 years old) from 4 rural sites were included in the analysis. Ever-smokers were more likely to be QuantiFERON-TB Gold In-Tube (QFT) positive than never smokers with an adjusted odds ratio (OR) of 1.34 (95% confidence interval (CI): 1.21&ndash;1.49). Among ever smokers, a significant linear dose&ndash;response relation was observed between duration of smoking (by years) and QFT positivity (p &lt; 0.001). Stratified analysis suggested that such an association was not influenced by gender and age. Evidence for interaction of smoking status with age was found.

Conclusions: Our results provide further evidence to support smoking might increase host susceptibility to TB infection. Populations under high risk of infection, such as elderly smokers, should be prior to TB infection controlling under a premise of community level intervention.

No MeSH data available.


Related in: MedlinePlus