Limits...
The value of grip test, lysophosphatidlycholines, glycerophosphocholine, ornithine, glucuronic acid decrement in assessment of nutritional and metabolic characteristics in hepatitis B cirrhosis

View Article: PubMed Central - PubMed

ABSTRACT

The liver is essential for the regulation of energy, protein and amino acids, as well as in other aspects of metabolism. To identify efficient indexes for evaluation of nutritional status and metabolic characteristics during different Child-Pugh stages of hepatitis B cirrhosis, 83 patients and 35 healthy individuals were enrolled in our study. We found that grip strength, triceps skinfold thickness (TSF), body fat and skeletal muscle of the patients were reduced compared to the control group (P<0.05). Ultra-high-performance liquid chromatography data combined with mass spectrometry (UPLC-MS) showed that levels of a variety of metabolites, including lysophosphatidylcholines (LysoPCs), glycerophosphocholine, ornithine and glucuronic acid were reduced in the serum of patients with hepatitis B cirrhosis (P<0.001). However, glycerophosphoserine and taurocholic acid levels were higher than in the control group (P<0.001). Moreover, grip strength was correlated with the Child-Pugh score (P<0.05). Serum albumin, total cholesterol, LDL, LysoPCs, glycerophosphocholine, ornithine, glucuronic acid, glycerophosphoserine and taurocholic acid were correlated with the Child-Pugh score (P<0.01). These findings suggested that grip strength and the above small molecular substances might be considered as sensitive and important indexes for evaluating nutritional status and metabolic characteristics of patients with hepatitis B cirrhosis, which may help assess prognosis and adjust nutritional treatment.

No MeSH data available.


Related in: MedlinePlus

The principal component (PCA) model of the serum samples from patients with hepatitis B cirrhosis and normal controls.A: Child-Pugh A group; B: Child-Pugh B group; C: Child-Pugh C group. Normal: Control group.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC5383249&req=5

pone.0175165.g001: The principal component (PCA) model of the serum samples from patients with hepatitis B cirrhosis and normal controls.A: Child-Pugh A group; B: Child-Pugh B group; C: Child-Pugh C group. Normal: Control group.

Mentions: A principal component analysis (PCA) model was established for all samples. The model parameters were R2X = 38.9% and Q2 = 27.3%. The scoring graph of the first principal component (t[1]) direction and the second principal component (t[2]) direction are shown in Fig 1. The model can distinguish clustering for the normal control group and patients with hepatitis B liver cirrhosis. At the same time, the model showed no outliers, indicating that the instrument was stable and the results were reliable. At the same time, all samples were constructed using orthogonal partial least squares discriminant analysis (OPLS-DA) models. The model parameters were R2X = 68.4%, R2Y = 76.1% and Q2 = 59.7%. The scoring graph of the first principal component (t[1]) direction and second principal component (t[2]) direction is shown in Fig 2. There was an obvious trend of clustering between groups.


The value of grip test, lysophosphatidlycholines, glycerophosphocholine, ornithine, glucuronic acid decrement in assessment of nutritional and metabolic characteristics in hepatitis B cirrhosis
The principal component (PCA) model of the serum samples from patients with hepatitis B cirrhosis and normal controls.A: Child-Pugh A group; B: Child-Pugh B group; C: Child-Pugh C group. Normal: Control group.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5383249&req=5

pone.0175165.g001: The principal component (PCA) model of the serum samples from patients with hepatitis B cirrhosis and normal controls.A: Child-Pugh A group; B: Child-Pugh B group; C: Child-Pugh C group. Normal: Control group.
Mentions: A principal component analysis (PCA) model was established for all samples. The model parameters were R2X = 38.9% and Q2 = 27.3%. The scoring graph of the first principal component (t[1]) direction and the second principal component (t[2]) direction are shown in Fig 1. The model can distinguish clustering for the normal control group and patients with hepatitis B liver cirrhosis. At the same time, the model showed no outliers, indicating that the instrument was stable and the results were reliable. At the same time, all samples were constructed using orthogonal partial least squares discriminant analysis (OPLS-DA) models. The model parameters were R2X = 68.4%, R2Y = 76.1% and Q2 = 59.7%. The scoring graph of the first principal component (t[1]) direction and second principal component (t[2]) direction is shown in Fig 2. There was an obvious trend of clustering between groups.

View Article: PubMed Central - PubMed

ABSTRACT

The liver is essential for the regulation of energy, protein and amino acids, as well as in other aspects of metabolism. To identify efficient indexes for evaluation of nutritional status and metabolic characteristics during different Child-Pugh stages of hepatitis B cirrhosis, 83 patients and 35 healthy individuals were enrolled in our study. We found that grip strength, triceps skinfold thickness (TSF), body fat and skeletal muscle of the patients were reduced compared to the control group (P<0.05). Ultra-high-performance liquid chromatography data combined with mass spectrometry (UPLC-MS) showed that levels of a variety of metabolites, including lysophosphatidylcholines (LysoPCs), glycerophosphocholine, ornithine and glucuronic acid were reduced in the serum of patients with hepatitis B cirrhosis (P<0.001). However, glycerophosphoserine and taurocholic acid levels were higher than in the control group (P<0.001). Moreover, grip strength was correlated with the Child-Pugh score (P<0.05). Serum albumin, total cholesterol, LDL, LysoPCs, glycerophosphocholine, ornithine, glucuronic acid, glycerophosphoserine and taurocholic acid were correlated with the Child-Pugh score (P<0.01). These findings suggested that grip strength and the above small molecular substances might be considered as sensitive and important indexes for evaluating nutritional status and metabolic characteristics of patients with hepatitis B cirrhosis, which may help assess prognosis and adjust nutritional treatment.

No MeSH data available.


Related in: MedlinePlus