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Similarities in trabecular hypertrophy with site-specific differences in cortical morphology between men and women with type 2 diabetes mellitus

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ABSTRACT

The goal of our study was to investigate interactions between sex and type 2 diabetes mellitus (T2DM) with regard to morphology of the peripheral skeleton. We recruited 85 subjects (mean age, 57±11.4 years): women with and without T2DM (n = 17; n = 16); and men with and without T2DM (n = 26; n = 26). All patients underwent high-resolution, peripheral, quantitative, computed tomography (HR-pQCT) imaging of the ultradistal radius (UR) and tibia (UT). Local bone geometry, bone mineral density (BMD), and bone microarchitecture were obtained by quantitative analysis of HR-pQCT images. To reduce the amount of data and avoid multi-collinearity, we performed a factor-analysis of HR-pQCT parameters. Based on factor weight, trabecular BMD, trabecular number, cortical thickness, cortical BMD, and total area were chosen for post-hoc analyses. At the radius and tibia, diabetic men and women exhibited trabecular hypertrophy, with a significant positive main effect of T2DM on trabecular number. At the radius, cortical thickness was higher in diabetic subjects (+20.1%, p = 0.003). Interestingly, there was a statistical trend that suggested attenuation of tibial cortical hypertrophy in diabetic men (cortical thickness, pinteraction = 0.052). Moreover, we found an expected sexual dichotomy, with higher trabecular BMD, Tb.N, cortical BMD, Ct.Th, and total area in men than in women (p≤ 0.003) at both measurement sites. Our results suggest that skeletal hypertrophy associated with T2DM is present in men and women, but appears attenuated at the tibial cortex in men.

No MeSH data available.


HR-pQCT of the ultradistal radius: Representative images.A) Woman with T2DM. B) Woman without T2DM. C) Man with T2DM. D) Man without T2DM.
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pone.0174664.g001: HR-pQCT of the ultradistal radius: Representative images.A) Woman with T2DM. B) Woman without T2DM. C) Man with T2DM. D) Man without T2DM.

Mentions: For all four subject groups (i.e., WT2DM, WCo; MT2DM, MCo), means and standard deviations of HR-pQCT parameters are given in Table 2. Moreover, Table 2 provides relative differences in HR-pQCT parameters between subjects with and without T2DM (with separate analyses for men and women). Fig 1 (radius) and Fig 2 (tibia) illustrate bone morphology in men and women with and without T2DM.


Similarities in trabecular hypertrophy with site-specific differences in cortical morphology between men and women with type 2 diabetes mellitus
HR-pQCT of the ultradistal radius: Representative images.A) Woman with T2DM. B) Woman without T2DM. C) Man with T2DM. D) Man without T2DM.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5383225&req=5

pone.0174664.g001: HR-pQCT of the ultradistal radius: Representative images.A) Woman with T2DM. B) Woman without T2DM. C) Man with T2DM. D) Man without T2DM.
Mentions: For all four subject groups (i.e., WT2DM, WCo; MT2DM, MCo), means and standard deviations of HR-pQCT parameters are given in Table 2. Moreover, Table 2 provides relative differences in HR-pQCT parameters between subjects with and without T2DM (with separate analyses for men and women). Fig 1 (radius) and Fig 2 (tibia) illustrate bone morphology in men and women with and without T2DM.

View Article: PubMed Central - PubMed

ABSTRACT

The goal of our study was to investigate interactions between sex and type 2 diabetes mellitus (T2DM) with regard to morphology of the peripheral skeleton. We recruited 85 subjects (mean age, 57±11.4 years): women with and without T2DM (n = 17; n = 16); and men with and without T2DM (n = 26; n = 26). All patients underwent high-resolution, peripheral, quantitative, computed tomography (HR-pQCT) imaging of the ultradistal radius (UR) and tibia (UT). Local bone geometry, bone mineral density (BMD), and bone microarchitecture were obtained by quantitative analysis of HR-pQCT images. To reduce the amount of data and avoid multi-collinearity, we performed a factor-analysis of HR-pQCT parameters. Based on factor weight, trabecular BMD, trabecular number, cortical thickness, cortical BMD, and total area were chosen for post-hoc analyses. At the radius and tibia, diabetic men and women exhibited trabecular hypertrophy, with a significant positive main effect of T2DM on trabecular number. At the radius, cortical thickness was higher in diabetic subjects (+20.1%, p = 0.003). Interestingly, there was a statistical trend that suggested attenuation of tibial cortical hypertrophy in diabetic men (cortical thickness, pinteraction = 0.052). Moreover, we found an expected sexual dichotomy, with higher trabecular BMD, Tb.N, cortical BMD, Ct.Th, and total area in men than in women (p≤ 0.003) at both measurement sites. Our results suggest that skeletal hypertrophy associated with T2DM is present in men and women, but appears attenuated at the tibial cortex in men.

No MeSH data available.