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Relationships between flortaucipir PET tau binding and amyloid burden, clinical diagnosis, age and cognition

View Article: PubMed Central - PubMed

ABSTRACT

The relation between tau, amyloid and cognition has yet to be fully defined. Using flortaucipir (18F-AV-1451) PET tau imaging in patients with varying amyloid and cognitive status, Pontecorvo et al. suggest that development of tau beyond the mesial temporal lobe is associated with, and may be dependent on, amyloid accumulation.

No MeSH data available.


Related in: MedlinePlus

Relationship between florbetapir PET SUVr, flortaucipir SUVr, diagnosis, age and ADAS score. (A) Scatterplot of relationship between florbetapir and flortaucipir SUVr for individual subjects by age, diagnosis and amyloid status. (B) Scatterplot of relationship between age and flortaucipir SUVr for individual subjects by age, diagnosis and amyloid status (r and P-values refer to Aβ+ subjects only). (C and D) Scatterplot of relationship between flortaucipir SUVr and cognition for individual subjects by diagnosis and amyloid status and age (<75 years, C; >75 years D). AD = Alzheimer’s disease; CN = cognitively normal.
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aww334-F5: Relationship between florbetapir PET SUVr, flortaucipir SUVr, diagnosis, age and ADAS score. (A) Scatterplot of relationship between florbetapir and flortaucipir SUVr for individual subjects by age, diagnosis and amyloid status. (B) Scatterplot of relationship between age and flortaucipir SUVr for individual subjects by age, diagnosis and amyloid status (r and P-values refer to Aβ+ subjects only). (C and D) Scatterplot of relationship between flortaucipir SUVr and cognition for individual subjects by diagnosis and amyloid status and age (<75 years, C; >75 years D). AD = Alzheimer’s disease; CN = cognitively normal.

Mentions: These relationships are represented graphically in Fig. 5. Figure 5A shows the relationship between florbetapir and flortaucipir SUVr. As previously described (Fig. 3), Aβ− florbetapir PET scans were consistently associated with low flortaucipir SUVr. While Aβ+ florbetapir PET scans were not always associated with elevated flortaucipir SUVr, the probability of an elevated flortaucipir SUVr increased as a function of florbetapir SUVr. Figure 5B shows the relationship between flortaucipir SUVr and age for both Aβ− and Aβ+ subjects. As noted above, Aβ− subjects had low posterior neocortical average flortaucipir SUVr regardless of age, whereas Aβ+ subjects had increased SUVr compared to controls, but showed an age-related decrease in flortaucipir SUVr. Finally, Fig. 5C and D shows the relationship between flortaucipir SUVr and ADAScog11 error score for Aβ+ subjects under 75 and over 75, respectively. Although the relationship between flortaucipir SUVr and ADAS was significant in both groups (P = 0.0039 and P = 0.0443, respectively), examination of the scatter plots shows that in the younger (<75 years) cohort, the demented subjects consistently showed elevated flortaucipir SUVr (>1.25, beyond the range of young controls), and the strength of relationship between flortaucipir SUVr and ADAS was limited primarily by a group of MCI subjects with high flortaucipir SUVr despite limited cognitive impairment. In contrast, approximately half of the demented patients over 75 years of age had relatively low flortaucipir SUVr despite substantial cognitive impairment. Visual examination of mean voxel-wise SUVr images from these >75-year-old subjects reveals flortaucipir retention in essentially the same regions as in the under 75 year olds, but with a lessor density. Thus, the mean images from the Aβ+ over 75 year old Aβ+ demented subjects most resemble the images from the Aβ+ MCI subjects less than 75 years old (Fig. 6)Figure 5


Relationships between flortaucipir PET tau binding and amyloid burden, clinical diagnosis, age and cognition
Relationship between florbetapir PET SUVr, flortaucipir SUVr, diagnosis, age and ADAS score. (A) Scatterplot of relationship between florbetapir and flortaucipir SUVr for individual subjects by age, diagnosis and amyloid status. (B) Scatterplot of relationship between age and flortaucipir SUVr for individual subjects by age, diagnosis and amyloid status (r and P-values refer to Aβ+ subjects only). (C and D) Scatterplot of relationship between flortaucipir SUVr and cognition for individual subjects by diagnosis and amyloid status and age (<75 years, C; >75 years D). AD = Alzheimer’s disease; CN = cognitively normal.
© Copyright Policy - cc-by-nc
Related In: Results  -  Collection

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Show All Figures
getmorefigures.php?uid=PMC5382945&req=5

aww334-F5: Relationship between florbetapir PET SUVr, flortaucipir SUVr, diagnosis, age and ADAS score. (A) Scatterplot of relationship between florbetapir and flortaucipir SUVr for individual subjects by age, diagnosis and amyloid status. (B) Scatterplot of relationship between age and flortaucipir SUVr for individual subjects by age, diagnosis and amyloid status (r and P-values refer to Aβ+ subjects only). (C and D) Scatterplot of relationship between flortaucipir SUVr and cognition for individual subjects by diagnosis and amyloid status and age (<75 years, C; >75 years D). AD = Alzheimer’s disease; CN = cognitively normal.
Mentions: These relationships are represented graphically in Fig. 5. Figure 5A shows the relationship between florbetapir and flortaucipir SUVr. As previously described (Fig. 3), Aβ− florbetapir PET scans were consistently associated with low flortaucipir SUVr. While Aβ+ florbetapir PET scans were not always associated with elevated flortaucipir SUVr, the probability of an elevated flortaucipir SUVr increased as a function of florbetapir SUVr. Figure 5B shows the relationship between flortaucipir SUVr and age for both Aβ− and Aβ+ subjects. As noted above, Aβ− subjects had low posterior neocortical average flortaucipir SUVr regardless of age, whereas Aβ+ subjects had increased SUVr compared to controls, but showed an age-related decrease in flortaucipir SUVr. Finally, Fig. 5C and D shows the relationship between flortaucipir SUVr and ADAScog11 error score for Aβ+ subjects under 75 and over 75, respectively. Although the relationship between flortaucipir SUVr and ADAS was significant in both groups (P = 0.0039 and P = 0.0443, respectively), examination of the scatter plots shows that in the younger (<75 years) cohort, the demented subjects consistently showed elevated flortaucipir SUVr (>1.25, beyond the range of young controls), and the strength of relationship between flortaucipir SUVr and ADAS was limited primarily by a group of MCI subjects with high flortaucipir SUVr despite limited cognitive impairment. In contrast, approximately half of the demented patients over 75 years of age had relatively low flortaucipir SUVr despite substantial cognitive impairment. Visual examination of mean voxel-wise SUVr images from these >75-year-old subjects reveals flortaucipir retention in essentially the same regions as in the under 75 year olds, but with a lessor density. Thus, the mean images from the Aβ+ over 75 year old Aβ+ demented subjects most resemble the images from the Aβ+ MCI subjects less than 75 years old (Fig. 6)Figure 5

View Article: PubMed Central - PubMed

ABSTRACT

The relation between tau, amyloid and cognition has yet to be fully defined. Using flortaucipir (18F-AV-1451) PET tau imaging in patients with varying amyloid and cognitive status, Pontecorvo et al. suggest that development of tau beyond the mesial temporal lobe is associated with, and may be dependent on, amyloid accumulation.

No MeSH data available.


Related in: MedlinePlus