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Relationships between flortaucipir PET tau binding and amyloid burden, clinical diagnosis, age and cognition

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ABSTRACT

The relation between tau, amyloid and cognition has yet to be fully defined. Using flortaucipir (18F-AV-1451) PET tau imaging in patients with varying amyloid and cognitive status, Pontecorvo et al. suggest that development of tau beyond the mesial temporal lobe is associated with, and may be dependent on, amyloid accumulation.

No MeSH data available.


Related in: MedlinePlus

Posterior neocortical composite SUVr for individual subjects by diagnostic category.X-axis: (diagnostic group, amyloid status), YCN are shown in red. Y-axis: flortaucipir (AV1451) combination SUVr. Horizontal reference line shows upper 99% confidence limit for YCN. AD = Alzheimer’s disease; CN = cognitively normal.
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aww334-F3: Posterior neocortical composite SUVr for individual subjects by diagnostic category.X-axis: (diagnostic group, amyloid status), YCN are shown in red. Y-axis: flortaucipir (AV1451) combination SUVr. Horizontal reference line shows upper 99% confidence limit for YCN. AD = Alzheimer’s disease; CN = cognitively normal.

Mentions: Figure 3 shows a scatter plot of SUVr averaged across representative cortical regions for individual subjects in the different diagnostic categories. Consistent with the statistical analysis above, Aβ− subjects had consistently low composite posterior cortical flortaucipir SUVr. Subjects with high composite posterior neocortical flortaucipir SUVr (outside the upper 99% confidence limits for YCN, dashed line) were predominantly Aβ+. However, it is clear that a significant proportion of Aβ+ subjects also had posterior cortical average SUVr that fell within the range of controls. Upon visual review of these images, many exhibited focal and/or unilateral flortaucipir uptake in neocortical regions, especially lateral temporal lobe (Fig. 4), a pattern that was rare, albeit not always absent, in Aβ− subjects.Figure 3


Relationships between flortaucipir PET tau binding and amyloid burden, clinical diagnosis, age and cognition
Posterior neocortical composite SUVr for individual subjects by diagnostic category.X-axis: (diagnostic group, amyloid status), YCN are shown in red. Y-axis: flortaucipir (AV1451) combination SUVr. Horizontal reference line shows upper 99% confidence limit for YCN. AD = Alzheimer’s disease; CN = cognitively normal.
© Copyright Policy - cc-by-nc
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC5382945&req=5

aww334-F3: Posterior neocortical composite SUVr for individual subjects by diagnostic category.X-axis: (diagnostic group, amyloid status), YCN are shown in red. Y-axis: flortaucipir (AV1451) combination SUVr. Horizontal reference line shows upper 99% confidence limit for YCN. AD = Alzheimer’s disease; CN = cognitively normal.
Mentions: Figure 3 shows a scatter plot of SUVr averaged across representative cortical regions for individual subjects in the different diagnostic categories. Consistent with the statistical analysis above, Aβ− subjects had consistently low composite posterior cortical flortaucipir SUVr. Subjects with high composite posterior neocortical flortaucipir SUVr (outside the upper 99% confidence limits for YCN, dashed line) were predominantly Aβ+. However, it is clear that a significant proportion of Aβ+ subjects also had posterior cortical average SUVr that fell within the range of controls. Upon visual review of these images, many exhibited focal and/or unilateral flortaucipir uptake in neocortical regions, especially lateral temporal lobe (Fig. 4), a pattern that was rare, albeit not always absent, in Aβ− subjects.Figure 3

View Article: PubMed Central - PubMed

ABSTRACT

The relation between tau, amyloid and cognition has yet to be fully defined. Using flortaucipir (18F-AV-1451) PET tau imaging in patients with varying amyloid and cognitive status, Pontecorvo et al. suggest that development of tau beyond the mesial temporal lobe is associated with, and may be dependent on, amyloid accumulation.

No MeSH data available.


Related in: MedlinePlus