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Disconnection between the default mode network and medial temporal lobes in post-traumatic amnesia

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ABSTRACT

See bigler (doi:10.1093/aww277) for a scientific commentary on this article: .

Post-traumatic amnesia is common following traumatic brain injury and is an important predictor of clinical outcome. De Simoni et al. report that post-traumatic amnesia results from a temporary disruption to functional brain networks involved in memory processing, with functional connectivity between the parahippocampal gyrus and posterior cingulate cortex particularly affected.

No MeSH data available.


Related in: MedlinePlus

Reduced white matter integrity in PTA patients compared to healthy controls. (A) Fractional anisotropy (FA) reductions in whole-brain white matter (skeletonized) from a direct contrast between the healthy controls and PTA patients. Green = normal white matter; red = damaged areas (low fractional anisotropy). Fractional anisotropy changes within the parahippocampal (B) and subgenual/retrosplenial (C) subdivisions of the cingulum bundle. (D) Parahippocampal (red) and subgenual/retrosplenial (green) subdivisions of the cingulum bundle. *Significance at P < 0.05, hash symbol indicates a trend. Error bars represent the standard error of the mean (SEM). HC = healthy controls; TBIC = TBI controls.
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aww241-F7: Reduced white matter integrity in PTA patients compared to healthy controls. (A) Fractional anisotropy (FA) reductions in whole-brain white matter (skeletonized) from a direct contrast between the healthy controls and PTA patients. Green = normal white matter; red = damaged areas (low fractional anisotropy). Fractional anisotropy changes within the parahippocampal (B) and subgenual/retrosplenial (C) subdivisions of the cingulum bundle. (D) Parahippocampal (red) and subgenual/retrosplenial (green) subdivisions of the cingulum bundle. *Significance at P < 0.05, hash symbol indicates a trend. Error bars represent the standard error of the mean (SEM). HC = healthy controls; TBIC = TBI controls.

Mentions: As expected, DTI provided evidence of white matter disruption in PTA patients. A whole-brain analysis showed widespread reductions fractional anisotropy, characteristic of diffuse axonal injury (Fig. 7A); in comparison to healthy controls, the PTA group showed areas of significant reductions in fractional anisotropy including the genu and splenium of the corpus callosum, anterior and posterior limbs of the internal capsule, external capsule, anterior and superior corona radiata, posterior thalamic radiation and uncinate fasciculus (Fig. 7A). At the whole brain level, there were no significant differences between healthy and TBI controls nor between PTA patients and TBI controls. No significant whole-brain differences were found for mean diffusivity, radial diffusivity or axial diffusivity.Figure 7


Disconnection between the default mode network and medial temporal lobes in post-traumatic amnesia
Reduced white matter integrity in PTA patients compared to healthy controls. (A) Fractional anisotropy (FA) reductions in whole-brain white matter (skeletonized) from a direct contrast between the healthy controls and PTA patients. Green = normal white matter; red = damaged areas (low fractional anisotropy). Fractional anisotropy changes within the parahippocampal (B) and subgenual/retrosplenial (C) subdivisions of the cingulum bundle. (D) Parahippocampal (red) and subgenual/retrosplenial (green) subdivisions of the cingulum bundle. *Significance at P < 0.05, hash symbol indicates a trend. Error bars represent the standard error of the mean (SEM). HC = healthy controls; TBIC = TBI controls.
© Copyright Policy - cc-by
Related In: Results  -  Collection

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Show All Figures
getmorefigures.php?uid=PMC5382939&req=5

aww241-F7: Reduced white matter integrity in PTA patients compared to healthy controls. (A) Fractional anisotropy (FA) reductions in whole-brain white matter (skeletonized) from a direct contrast between the healthy controls and PTA patients. Green = normal white matter; red = damaged areas (low fractional anisotropy). Fractional anisotropy changes within the parahippocampal (B) and subgenual/retrosplenial (C) subdivisions of the cingulum bundle. (D) Parahippocampal (red) and subgenual/retrosplenial (green) subdivisions of the cingulum bundle. *Significance at P < 0.05, hash symbol indicates a trend. Error bars represent the standard error of the mean (SEM). HC = healthy controls; TBIC = TBI controls.
Mentions: As expected, DTI provided evidence of white matter disruption in PTA patients. A whole-brain analysis showed widespread reductions fractional anisotropy, characteristic of diffuse axonal injury (Fig. 7A); in comparison to healthy controls, the PTA group showed areas of significant reductions in fractional anisotropy including the genu and splenium of the corpus callosum, anterior and posterior limbs of the internal capsule, external capsule, anterior and superior corona radiata, posterior thalamic radiation and uncinate fasciculus (Fig. 7A). At the whole brain level, there were no significant differences between healthy and TBI controls nor between PTA patients and TBI controls. No significant whole-brain differences were found for mean diffusivity, radial diffusivity or axial diffusivity.Figure 7

View Article: PubMed Central - PubMed

ABSTRACT

See bigler (doi:10.1093/aww277) for a scientific commentary on this article: .

Post-traumatic amnesia is common following traumatic brain injury and is an important predictor of clinical outcome. De Simoni et al. report that post-traumatic amnesia results from a temporary disruption to functional brain networks involved in memory processing, with functional connectivity between the parahippocampal gyrus and posterior cingulate cortex particularly affected.

No MeSH data available.


Related in: MedlinePlus